SiRNA in MSC-derived exosomes silences CTGF gene for locomotor recovery in spinal cord injury rats

SiRNA in MSC-derived exosomes silences CTGF gene for locomotor recovery in spinal cord injury rats

Abstract Background How to obtain a small interfering RNA (siRNA) vector has become a moot point in recent years. Exosomes (Exo) show advantages of long survival time in vivo, high transmission efficiency, and easy penetration across the blood-spinal cord barrier, renowned as excellent carriers of b...

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Bibliographic Details
Main Authors: Wei Huang, Mingjia Qu, Lu Li, Tao Liu, Miaoman Lin, Xiaobing Yu
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Stem Cell Research & Therapy
Subjects:
Spinal cord injury
Exosomes: Mesenchymal stem cells
RNA interference
Small interfering RNA
Online Access:https://doi.org/10.1186/s13287-021-02401-x

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