SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis

Metastatic disease is the major reason for breast cancer-related deaths; therefore, a better understanding of this process and its players is needed. Here the authors report the role of SIRT7 in inhibiting SMAD4-mediated breast cancer metastasis providing a possible therapeutic avenue.

書誌詳細
主要な著者: Xiaolong Tang, Lei Shi, Ni Xie, Zuojun Liu, Minxian Qian, Fanbiao Meng, Qingyang Xu, Mingyan Zhou, Xinyue Cao, Wei-Guo Zhu, Baohua Liu
フォーマット: 論文
言語:English
出版事項: Nature Portfolio 2017-08-01
シリーズ:Nature Communications
オンライン・アクセス:https://doi.org/10.1038/s41467-017-00396-9
その他の書誌記述
要約:Metastatic disease is the major reason for breast cancer-related deaths; therefore, a better understanding of this process and its players is needed. Here the authors report the role of SIRT7 in inhibiting SMAD4-mediated breast cancer metastasis providing a possible therapeutic avenue.
ISSN:2041-1723