A Potential Role for Epigenetically Mediated Trained Immunity in Food Allergy
The prevalence of IgE-mediated food allergy is increasing at a rapid pace in many countries. The association of high food allergy rates with Westernized lifestyles suggests the role of gene-environment interactions, potentially underpinned by epigenetic variation, in mediating this process. Recent s...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004220303564 |
| _version_ | 1818932425647980544 |
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| author | Samira Imran Melanie R. Neeland Rebecca Shepherd Nicole Messina Kirsten P. Perrett Mihai G. Netea Nigel Curtis Richard Saffery Boris Novakovic |
| author_facet | Samira Imran Melanie R. Neeland Rebecca Shepherd Nicole Messina Kirsten P. Perrett Mihai G. Netea Nigel Curtis Richard Saffery Boris Novakovic |
| author_sort | Samira Imran |
| collection | DOAJ |
| description | The prevalence of IgE-mediated food allergy is increasing at a rapid pace in many countries. The association of high food allergy rates with Westernized lifestyles suggests the role of gene-environment interactions, potentially underpinned by epigenetic variation, in mediating this process. Recent studies have implicated innate immune system dysfunction in the development and persistence of food allergy. These responses are characterized by increased circulating frequency of innate immune cells and heightened inflammatory responses to bacterial stimulation in food allergic patients. These signatures mirror those described in trained immunity, whereby innate immune cells retain a “memory” of earlier microbial encounters, thus influencing subsequent immune responses. Here, we propose that a robust multi-omics approach that integrates immunological, transcriptomic, and epigenomic datasets, combined with well-phenotyped and longitudinal food allergy cohorts, can inform the potential role of trained immunity in food allergy. |
| first_indexed | 2024-12-20T04:32:17Z |
| format | Article |
| id | doaj.art-61efe68e23d14f57acd9b439308ee640 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-20T04:32:17Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-61efe68e23d14f57acd9b439308ee6402022-12-21T19:53:20ZengElsevieriScience2589-00422020-06-01236101171A Potential Role for Epigenetically Mediated Trained Immunity in Food AllergySamira Imran0Melanie R. Neeland1Rebecca Shepherd2Nicole Messina3Kirsten P. Perrett4Mihai G. Netea5Nigel Curtis6Richard Saffery7Boris Novakovic8Murdoch Children's Research Institute, and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Flemington Road, Parkville, VIC 3052, AustraliaMurdoch Children's Research Institute, and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Flemington Road, Parkville, VIC 3052, AustraliaMurdoch Children's Research Institute, and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Flemington Road, Parkville, VIC 3052, AustraliaMurdoch Children's Research Institute, and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Flemington Road, Parkville, VIC 3052, AustraliaMurdoch Children's Research Institute, and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Flemington Road, Parkville, VIC 3052, Australia; Department of Allergy and Immunology, Royal Children's Hospital, Melbourne, AustraliaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Department for Genomics and Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, GermanyMurdoch Children's Research Institute, and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Flemington Road, Parkville, VIC 3052, AustraliaMurdoch Children's Research Institute, and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Flemington Road, Parkville, VIC 3052, AustraliaMurdoch Children's Research Institute, and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Flemington Road, Parkville, VIC 3052, Australia; Corresponding authorThe prevalence of IgE-mediated food allergy is increasing at a rapid pace in many countries. The association of high food allergy rates with Westernized lifestyles suggests the role of gene-environment interactions, potentially underpinned by epigenetic variation, in mediating this process. Recent studies have implicated innate immune system dysfunction in the development and persistence of food allergy. These responses are characterized by increased circulating frequency of innate immune cells and heightened inflammatory responses to bacterial stimulation in food allergic patients. These signatures mirror those described in trained immunity, whereby innate immune cells retain a “memory” of earlier microbial encounters, thus influencing subsequent immune responses. Here, we propose that a robust multi-omics approach that integrates immunological, transcriptomic, and epigenomic datasets, combined with well-phenotyped and longitudinal food allergy cohorts, can inform the potential role of trained immunity in food allergy.http://www.sciencedirect.com/science/article/pii/S2589004220303564ImmunologySystems BiologyOmics |
| spellingShingle | Samira Imran Melanie R. Neeland Rebecca Shepherd Nicole Messina Kirsten P. Perrett Mihai G. Netea Nigel Curtis Richard Saffery Boris Novakovic A Potential Role for Epigenetically Mediated Trained Immunity in Food Allergy iScience Immunology Systems Biology Omics |
| title | A Potential Role for Epigenetically Mediated Trained Immunity in Food Allergy |
| title_full | A Potential Role for Epigenetically Mediated Trained Immunity in Food Allergy |
| title_fullStr | A Potential Role for Epigenetically Mediated Trained Immunity in Food Allergy |
| title_full_unstemmed | A Potential Role for Epigenetically Mediated Trained Immunity in Food Allergy |
| title_short | A Potential Role for Epigenetically Mediated Trained Immunity in Food Allergy |
| title_sort | potential role for epigenetically mediated trained immunity in food allergy |
| topic | Immunology Systems Biology Omics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004220303564 |
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