Characterization of Healthcare-Associated and Community-Associated Clostridioides difficile Infections among Adults, Canada, 2015–2019
We investigated epidemiologic and molecular characteristics of healthcare-associated (HA) and community-associated (CA) Clostridioides difficile infection (CDI) among adult patients in Canadian Nosocomial Infection Surveillance Program hospitals during 2015–2019. The study encompassed 18,455 CDI ca...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2022-06-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/28/6/21-2262_article |
| _version_ | 1811247234988113920 |
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| author | Tim Du Kelly B. Choi Anada Silva George R. Golding Linda Pelude Romeo Hizon Ghada N. Al-Rawahi James Brooks Blanda Chow Jun C. Collet Jeannette L. Comeau Ian Davis Gerald A. Evans Charles Frenette Guanghong Han Jennie Johnstone Pamela Kibsey Kevin C. Katz Joanne M. Langley Bonita E. Lee Yves Longtin Dominik Mertz Jessica Minion Michelle Science Jocelyn A. Srigley Paula Stagg Kathryn N. Suh Nisha Thampi Alice Wong Susy S. Hota |
| author_facet | Tim Du Kelly B. Choi Anada Silva George R. Golding Linda Pelude Romeo Hizon Ghada N. Al-Rawahi James Brooks Blanda Chow Jun C. Collet Jeannette L. Comeau Ian Davis Gerald A. Evans Charles Frenette Guanghong Han Jennie Johnstone Pamela Kibsey Kevin C. Katz Joanne M. Langley Bonita E. Lee Yves Longtin Dominik Mertz Jessica Minion Michelle Science Jocelyn A. Srigley Paula Stagg Kathryn N. Suh Nisha Thampi Alice Wong Susy S. Hota |
| author_sort | Tim Du |
| collection | DOAJ |
| description |
We investigated epidemiologic and molecular characteristics of healthcare-associated (HA) and community-associated (CA) Clostridioides difficile infection (CDI) among adult patients in Canadian Nosocomial Infection Surveillance Program hospitals during 2015–2019. The study encompassed 18,455 CDI cases, 13,735 (74.4%) HA and 4,720 (25.6%) CA. During 2015–2019, HA CDI rates decreased by 23.8%, whereas CA decreased by 18.8%. HA CDI was significantly associated with increased 30-day all-cause mortality as compared with CA CDI (p<0.01). Of 2,506 isolates analyzed, the most common ribotypes (RTs) were RT027, RT106, RT014, and RT020. RT027 was more often associated with CDI-attributable death than was non-RT027, regardless of acquisition type. Overall resistance C. difficile rates were similar for all drugs tested except moxifloxacin. Adult HA and CA CDI rates have declined, coinciding with changes in prevalence of RT027 and RT106. Infection prevention and control and continued national surveillance are integral to clarifying CDI epidemiology, investigation, and control.
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| first_indexed | 2024-04-12T15:06:33Z |
| format | Article |
| id | doaj.art-61efff4755304e4093d6f769cfe4c0e3 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-12T15:06:33Z |
| publishDate | 2022-06-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-61efff4755304e4093d6f769cfe4c0e32022-12-22T03:27:56ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592022-06-012861128113610.3201/eid2806.212262Characterization of Healthcare-Associated and Community-Associated Clostridioides difficile Infections among Adults, Canada, 2015–2019Tim DuKelly B. ChoiAnada SilvaGeorge R. GoldingLinda PeludeRomeo HizonGhada N. Al-RawahiJames BrooksBlanda ChowJun C. ColletJeannette L. ComeauIan DavisGerald A. EvansCharles FrenetteGuanghong HanJennie JohnstonePamela KibseyKevin C. KatzJoanne M. LangleyBonita E. LeeYves LongtinDominik MertzJessica MinionMichelle ScienceJocelyn A. SrigleyPaula StaggKathryn N. SuhNisha ThampiAlice WongSusy S. Hota We investigated epidemiologic and molecular characteristics of healthcare-associated (HA) and community-associated (CA) Clostridioides difficile infection (CDI) among adult patients in Canadian Nosocomial Infection Surveillance Program hospitals during 2015–2019. The study encompassed 18,455 CDI cases, 13,735 (74.4%) HA and 4,720 (25.6%) CA. During 2015–2019, HA CDI rates decreased by 23.8%, whereas CA decreased by 18.8%. HA CDI was significantly associated with increased 30-day all-cause mortality as compared with CA CDI (p<0.01). Of 2,506 isolates analyzed, the most common ribotypes (RTs) were RT027, RT106, RT014, and RT020. RT027 was more often associated with CDI-attributable death than was non-RT027, regardless of acquisition type. Overall resistance C. difficile rates were similar for all drugs tested except moxifloxacin. Adult HA and CA CDI rates have declined, coinciding with changes in prevalence of RT027 and RT106. Infection prevention and control and continued national surveillance are integral to clarifying CDI epidemiology, investigation, and control. https://wwwnc.cdc.gov/eid/article/28/6/21-2262_articleC. difficleClostridioides difficile infectionbacteriaantimicrobial resistancehealthcare-associated infectionscommunity-associated infections |
| spellingShingle | Tim Du Kelly B. Choi Anada Silva George R. Golding Linda Pelude Romeo Hizon Ghada N. Al-Rawahi James Brooks Blanda Chow Jun C. Collet Jeannette L. Comeau Ian Davis Gerald A. Evans Charles Frenette Guanghong Han Jennie Johnstone Pamela Kibsey Kevin C. Katz Joanne M. Langley Bonita E. Lee Yves Longtin Dominik Mertz Jessica Minion Michelle Science Jocelyn A. Srigley Paula Stagg Kathryn N. Suh Nisha Thampi Alice Wong Susy S. Hota Characterization of Healthcare-Associated and Community-Associated Clostridioides difficile Infections among Adults, Canada, 2015–2019 Emerging Infectious Diseases C. difficle Clostridioides difficile infection bacteria antimicrobial resistance healthcare-associated infections community-associated infections |
| title | Characterization of Healthcare-Associated and Community-Associated Clostridioides difficile Infections among Adults, Canada, 2015–2019 |
| title_full | Characterization of Healthcare-Associated and Community-Associated Clostridioides difficile Infections among Adults, Canada, 2015–2019 |
| title_fullStr | Characterization of Healthcare-Associated and Community-Associated Clostridioides difficile Infections among Adults, Canada, 2015–2019 |
| title_full_unstemmed | Characterization of Healthcare-Associated and Community-Associated Clostridioides difficile Infections among Adults, Canada, 2015–2019 |
| title_short | Characterization of Healthcare-Associated and Community-Associated Clostridioides difficile Infections among Adults, Canada, 2015–2019 |
| title_sort | characterization of healthcare associated and community associated clostridioides difficile infections among adults canada 2015 2019 |
| topic | C. difficle Clostridioides difficile infection bacteria antimicrobial resistance healthcare-associated infections community-associated infections |
| url | https://wwwnc.cdc.gov/eid/article/28/6/21-2262_article |
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