Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome
Backgrounds Recently, alternative surrogate endpoints such as a 30% or 40% decline in estimated glomerular filtration rate (eGFR) or eGFR slope over 2 to 3 years have been proposed for predicting renal outcomes. However, the impact of GFR estimation methods on the accuracy and effectiveness of surro...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2021-06-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | http://www.krcp-ksn.org/upload/pdf/j-krcp-20-210.pdf |
| _version_ | 1818407194863861760 |
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| author | Kipyo Kim Eunji Baek Suryeong Go Hyung-Eun Son Ji-Young Ryu Yongjin Yi Jong Cheol Jeong Sejoong Kim Ho Jun Chin |
| author_facet | Kipyo Kim Eunji Baek Suryeong Go Hyung-Eun Son Ji-Young Ryu Yongjin Yi Jong Cheol Jeong Sejoong Kim Ho Jun Chin |
| author_sort | Kipyo Kim |
| collection | DOAJ |
| description | Backgrounds Recently, alternative surrogate endpoints such as a 30% or 40% decline in estimated glomerular filtration rate (eGFR) or eGFR slope over 2 to 3 years have been proposed for predicting renal outcomes. However, the impact of GFR estimation methods on the accuracy and effectiveness of surrogate markers is unknown. Methods We retrospectively enrolled participants in health screening programs at three hospitals from 1995 to 2009. We defined two different participant groups as YR1 and YR3, which had available 1-year or 3-year eGFR values along with their baseline eGFR levels. We compared the effectiveness of eGFR percentage change or slope to estimate end-stage renal disease (ESRD) risk according to two estimating equations (modified Modification of Diet in Renal Disease equation [eGFRm] and Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation [eGFRc]) for GFR. Results In the YR1 and YR3 groups, 9,971 and 10,171 candidates were enrolled and ESRD incidence during follow-up was 0.26% and 0.19%, respectively. The eGFR percentage change was more effective than eGFR slope in estimating ESRD risk, regardless of the method of estimation. A 40% of decline in eGFR was better than 30%, and a 3-year baseline period was better than a 1-year period for prediction accuracy. Although some diagnostic indices from the CKD-EPI equation were better, we found no significant differences in the discriminative ability and hazard ratios for incident ESRD between eGFRc and eGFRm in either eGFR percentage change or eGFR slope. Conclusion There were no significant differences in the prediction accuracy of GFR percentage change or eGFR slope between eGFRc and eGFRm in the general population. |
| first_indexed | 2024-12-14T09:23:58Z |
| format | Article |
| id | doaj.art-61f0e89d5337456886a1dfc82c7b29e7 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 2211-9140 |
| language | English |
| last_indexed | 2024-12-14T09:23:58Z |
| publishDate | 2021-06-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-61f0e89d5337456886a1dfc82c7b29e72022-12-21T23:08:13ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322211-91402021-06-0140222023010.23876/j.krcp.20.2106047Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcomeKipyo Kim0Eunji Baek1Suryeong Go2Hyung-Eun Son3Ji-Young Ryu4Yongjin Yi5Jong Cheol Jeong6Sejoong Kim7Ho Jun Chin8 Division of Nephrology and Hypertension, Department of Internal Medicine, Inha University College of Medicine, Incheon, Republic of Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea Division of Nephrology, Department of Internal Medicine, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Republic of Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaBackgrounds Recently, alternative surrogate endpoints such as a 30% or 40% decline in estimated glomerular filtration rate (eGFR) or eGFR slope over 2 to 3 years have been proposed for predicting renal outcomes. However, the impact of GFR estimation methods on the accuracy and effectiveness of surrogate markers is unknown. Methods We retrospectively enrolled participants in health screening programs at three hospitals from 1995 to 2009. We defined two different participant groups as YR1 and YR3, which had available 1-year or 3-year eGFR values along with their baseline eGFR levels. We compared the effectiveness of eGFR percentage change or slope to estimate end-stage renal disease (ESRD) risk according to two estimating equations (modified Modification of Diet in Renal Disease equation [eGFRm] and Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation [eGFRc]) for GFR. Results In the YR1 and YR3 groups, 9,971 and 10,171 candidates were enrolled and ESRD incidence during follow-up was 0.26% and 0.19%, respectively. The eGFR percentage change was more effective than eGFR slope in estimating ESRD risk, regardless of the method of estimation. A 40% of decline in eGFR was better than 30%, and a 3-year baseline period was better than a 1-year period for prediction accuracy. Although some diagnostic indices from the CKD-EPI equation were better, we found no significant differences in the discriminative ability and hazard ratios for incident ESRD between eGFRc and eGFRm in either eGFR percentage change or eGFR slope. Conclusion There were no significant differences in the prediction accuracy of GFR percentage change or eGFR slope between eGFRc and eGFRm in the general population.http://www.krcp-ksn.org/upload/pdf/j-krcp-20-210.pdfchronic kidney diseaseend-stage renal diseaseglomerular filtration raterenal endpointsurrogate endpoint |
| spellingShingle | Kipyo Kim Eunji Baek Suryeong Go Hyung-Eun Son Ji-Young Ryu Yongjin Yi Jong Cheol Jeong Sejoong Kim Ho Jun Chin Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome Kidney Research and Clinical Practice chronic kidney disease end-stage renal disease glomerular filtration rate renal endpoint surrogate endpoint |
| title | Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome |
| title_full | Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome |
| title_fullStr | Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome |
| title_full_unstemmed | Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome |
| title_short | Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome |
| title_sort | effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome |
| topic | chronic kidney disease end-stage renal disease glomerular filtration rate renal endpoint surrogate endpoint |
| url | http://www.krcp-ksn.org/upload/pdf/j-krcp-20-210.pdf |
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