Formation of Neuronal Circuits by Interactions between Neuronal Populations Derived from Different Origins in the Drosophila Visual Center
A wide variety of neurons, including populations derived from different origins, are precisely arranged and correctly connected with their partner to establish a functional neural circuit during brain development. The molecular mechanisms that orchestrate the production and arrangement of these neur...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-04-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124716303278 |
| _version_ | 1818539739195637760 |
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| author | Takumi Suzuki Eri Hasegawa Yasuhiro Nakai Masako Kaido Rie Takayama Makoto Sato |
| author_facet | Takumi Suzuki Eri Hasegawa Yasuhiro Nakai Masako Kaido Rie Takayama Makoto Sato |
| author_sort | Takumi Suzuki |
| collection | DOAJ |
| description | A wide variety of neurons, including populations derived from different origins, are precisely arranged and correctly connected with their partner to establish a functional neural circuit during brain development. The molecular mechanisms that orchestrate the production and arrangement of these neurons have been obscure. Here, we demonstrate that cell-cell interactions play an important role in establishing the arrangement of neurons of different origins in the Drosophila visual center. Specific types of neurons born outside the medulla primordium migrate tangentially into the developing medulla cortex. During their tangential migration, these neurons express the repellent ligand Slit, and the two layers that the neurons intercalate between express the receptors Robo2 and Robo3. Genetic analysis suggests that Slit-Robo signaling may control the positioning of the layer cells or their processes to form a path for migration. Our results suggest that conserved axon guidance signaling is involved in the interactions between neurons of different origins during brain development. |
| first_indexed | 2024-12-11T21:46:04Z |
| format | Article |
| id | doaj.art-61f25aea74e143deba4914dfd6b47052 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-11T21:46:04Z |
| publishDate | 2016-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-61f25aea74e143deba4914dfd6b470522022-12-22T00:49:36ZengElsevierCell Reports2211-12472016-04-0115349950910.1016/j.celrep.2016.03.056Formation of Neuronal Circuits by Interactions between Neuronal Populations Derived from Different Origins in the Drosophila Visual CenterTakumi Suzuki0Eri Hasegawa1Yasuhiro Nakai2Masako Kaido3Rie Takayama4Makoto Sato5Brain/Liver Interface Medicine Research Center, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, JapanBrain/Liver Interface Medicine Research Center, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, JapanBrain/Liver Interface Medicine Research Center, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, JapanBrain/Liver Interface Medicine Research Center, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, JapanBrain/Liver Interface Medicine Research Center, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, JapanBrain/Liver Interface Medicine Research Center, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, JapanA wide variety of neurons, including populations derived from different origins, are precisely arranged and correctly connected with their partner to establish a functional neural circuit during brain development. The molecular mechanisms that orchestrate the production and arrangement of these neurons have been obscure. Here, we demonstrate that cell-cell interactions play an important role in establishing the arrangement of neurons of different origins in the Drosophila visual center. Specific types of neurons born outside the medulla primordium migrate tangentially into the developing medulla cortex. During their tangential migration, these neurons express the repellent ligand Slit, and the two layers that the neurons intercalate between express the receptors Robo2 and Robo3. Genetic analysis suggests that Slit-Robo signaling may control the positioning of the layer cells or their processes to form a path for migration. Our results suggest that conserved axon guidance signaling is involved in the interactions between neurons of different origins during brain development.http://www.sciencedirect.com/science/article/pii/S2211124716303278 |
| spellingShingle | Takumi Suzuki Eri Hasegawa Yasuhiro Nakai Masako Kaido Rie Takayama Makoto Sato Formation of Neuronal Circuits by Interactions between Neuronal Populations Derived from Different Origins in the Drosophila Visual Center Cell Reports |
| title | Formation of Neuronal Circuits by Interactions between Neuronal Populations Derived from Different Origins in the Drosophila Visual Center |
| title_full | Formation of Neuronal Circuits by Interactions between Neuronal Populations Derived from Different Origins in the Drosophila Visual Center |
| title_fullStr | Formation of Neuronal Circuits by Interactions between Neuronal Populations Derived from Different Origins in the Drosophila Visual Center |
| title_full_unstemmed | Formation of Neuronal Circuits by Interactions between Neuronal Populations Derived from Different Origins in the Drosophila Visual Center |
| title_short | Formation of Neuronal Circuits by Interactions between Neuronal Populations Derived from Different Origins in the Drosophila Visual Center |
| title_sort | formation of neuronal circuits by interactions between neuronal populations derived from different origins in the drosophila visual center |
| url | http://www.sciencedirect.com/science/article/pii/S2211124716303278 |
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