Potential effect of kaempferol against various malignancies: recent advances and perspectives
ABSTRACTKaempferol is a flavonoid present in many eatable plants. Researchers discovered a link between consuming foods high in kaempferol and lowering the threat for acquiring many diseases, including cardiovascular disease, diabetes, obesity and cancer. Kaempferol can inhibit AHR transcription, mo...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Food and Agricultural Immunology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/09540105.2023.2265690 |
| _version_ | 1797447850260430848 |
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| author | Muhammad Shahbaz Muhammad Imran Ushna Momal Hammad Naeem Suliman A. Alsagaby Waleed Al Abdulmonem Ahmed H. El-Ghorab Mohammed M. Ghoneim Muzzamal Hussain Mohamed E. Shaker Mohamed A. Abdelgawad Ahmed Mujtaba Entessar Al Jbawi |
| author_facet | Muhammad Shahbaz Muhammad Imran Ushna Momal Hammad Naeem Suliman A. Alsagaby Waleed Al Abdulmonem Ahmed H. El-Ghorab Mohammed M. Ghoneim Muzzamal Hussain Mohamed E. Shaker Mohamed A. Abdelgawad Ahmed Mujtaba Entessar Al Jbawi |
| author_sort | Muhammad Shahbaz |
| collection | DOAJ |
| description | ABSTRACTKaempferol is a flavonoid present in many eatable plants. Researchers discovered a link between consuming foods high in kaempferol and lowering the threat for acquiring many diseases, including cardiovascular disease, diabetes, obesity and cancer. Kaempferol can inhibit AHR transcription, modulate ERK signalling pathway and NF-κB pathways, block MAPK and AP1 signalling pathways and perform more anticancer roles. Kaempferol also has the ability to act against diabetes via suppressed phosphorylation of (IKK) IkB kinase, (IRS-1) insulin receptor substrate-1 and (IKK) IkB kinase through the hepatic IKK/NF-B signalling pathways and significantly enhanced insulin secretion and synthesis. Kaempferol protects cardiomyocytes from anoxia/reoxygenation (A/R)-induced damage by lowering LDH release, improving cell survival, reducing A/R-induced ROS formation, and release of cytochrome c. This knowledge may aid in understanding health advantages of medicinal plants that contain kaempferol and may lead to the development of the flavonoid as a potential agents for disease aversion and therapy. |
| first_indexed | 2024-03-09T14:02:56Z |
| format | Article |
| id | doaj.art-61f26f01b3bd4a8bad91a4b1a9f3a98d |
| institution | Directory Open Access Journal |
| issn | 0954-0105 1465-3443 |
| language | English |
| last_indexed | 2024-03-09T14:02:56Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Food and Agricultural Immunology |
| spelling | doaj.art-61f26f01b3bd4a8bad91a4b1a9f3a98d2023-11-30T06:57:34ZengTaylor & Francis GroupFood and Agricultural Immunology0954-01051465-34432023-12-0134110.1080/09540105.2023.2265690Potential effect of kaempferol against various malignancies: recent advances and perspectivesMuhammad Shahbaz0Muhammad Imran1Ushna Momal2Hammad Naeem3Suliman A. Alsagaby4Waleed Al Abdulmonem5Ahmed H. El-Ghorab6Mohammed M. Ghoneim7Muzzamal Hussain8Mohamed E. Shaker9Mohamed A. Abdelgawad10Ahmed Mujtaba11Entessar Al Jbawi12Department of Food Science and Technology, Muhammad Nawaz Shareef University of Agriculture, Multan, PakistanDepartment of Food Science and Technology, University of Narowal, Narowal, PakistanDepartment of Food Science and Technology, Muhammad Nawaz Shareef University of Agriculture, Multan, PakistanDepartment of Food Science and Technology, Muhammad Nawaz Shareef University of Agriculture, Multan, PakistanDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, AL-Majmaah, Saudi ArabiaDepartment of Pathology, College of Medicine, Qassim University, Buraidah, Kingdom of Saudi ArabiaDepartment of Chemistry, College of Science, Jouf University, Sakaka, Saudi ArabiaDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah, Saudi ArabiaDepartment of Food Sciences, Government College University Faisalabad, Faisalabad, PakistanDepartment of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaDepartment of Food Sciences and Technology, Faculty of Engineering and Technology, Hamdard University, Islamabad, PakistanAgricultural Extension Directorate, MAAR, Damascus, SyriaABSTRACTKaempferol is a flavonoid present in many eatable plants. Researchers discovered a link between consuming foods high in kaempferol and lowering the threat for acquiring many diseases, including cardiovascular disease, diabetes, obesity and cancer. Kaempferol can inhibit AHR transcription, modulate ERK signalling pathway and NF-κB pathways, block MAPK and AP1 signalling pathways and perform more anticancer roles. Kaempferol also has the ability to act against diabetes via suppressed phosphorylation of (IKK) IkB kinase, (IRS-1) insulin receptor substrate-1 and (IKK) IkB kinase through the hepatic IKK/NF-B signalling pathways and significantly enhanced insulin secretion and synthesis. Kaempferol protects cardiomyocytes from anoxia/reoxygenation (A/R)-induced damage by lowering LDH release, improving cell survival, reducing A/R-induced ROS formation, and release of cytochrome c. This knowledge may aid in understanding health advantages of medicinal plants that contain kaempferol and may lead to the development of the flavonoid as a potential agents for disease aversion and therapy.https://www.tandfonline.com/doi/10.1080/09540105.2023.2265690Kaempferolanticancerapoptosisanti-inflammatory rolecardio-protectiveflavonoids |
| spellingShingle | Muhammad Shahbaz Muhammad Imran Ushna Momal Hammad Naeem Suliman A. Alsagaby Waleed Al Abdulmonem Ahmed H. El-Ghorab Mohammed M. Ghoneim Muzzamal Hussain Mohamed E. Shaker Mohamed A. Abdelgawad Ahmed Mujtaba Entessar Al Jbawi Potential effect of kaempferol against various malignancies: recent advances and perspectives Food and Agricultural Immunology Kaempferol anticancer apoptosis anti-inflammatory role cardio-protective flavonoids |
| title | Potential effect of kaempferol against various malignancies: recent advances and perspectives |
| title_full | Potential effect of kaempferol against various malignancies: recent advances and perspectives |
| title_fullStr | Potential effect of kaempferol against various malignancies: recent advances and perspectives |
| title_full_unstemmed | Potential effect of kaempferol against various malignancies: recent advances and perspectives |
| title_short | Potential effect of kaempferol against various malignancies: recent advances and perspectives |
| title_sort | potential effect of kaempferol against various malignancies recent advances and perspectives |
| topic | Kaempferol anticancer apoptosis anti-inflammatory role cardio-protective flavonoids |
| url | https://www.tandfonline.com/doi/10.1080/09540105.2023.2265690 |
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