IKBKE-driven TPL2 and MEK1 phosphorylations sustain constitutive ERK1/2 activation in tumor cells

IKBKE have been associated with numerous cancers. As a result, IKBKE have emerged as potential target for cancer therapy. Accumulating evidence support that IKBKE orchestrate tumor cell survival in cancers. Here we evaluated the possible link between IKBKE and ERK phosphorylation. The effects of IKB...

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Bibliographic Details
Main Author: Serkan Ismail Göktuna
Format: Article
Language:English
Published: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund 2022-02-01
Series:EXCLI Journal : Experimental and Clinical Sciences
Subjects:
Online Access:https://www.excli.de/index.php/excli/article/view/4578