Soya-cerebroside reduces IL-1β-induced MMP-1 production in chondrocytes and inhibits cartilage degradation: implications for the treatment of osteoarthritis
Osteoarthritis (OA) commonly affects the synovial joint and is characterized by degradation of articular cartilage, which is largely mobilized by increased matrix metalloproteinase (MMP) activity. Soya-cerebroside, an extract of Cordyceps militaris, inhibits inflammatory cytokine production and mono...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Food and Agricultural Immunology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09540105.2019.1611745 |
| _version_ | 1819013529375604736 |
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| author | Shan-Chi Liu Chun-Hao Tsai Tung-Ying Wu Chang-Hai Tsai Fuu-Jen Tsai Jing-Gung Chung Chih-Yang Huang Jai-Sing Yang Yuan-Man Hsu Mei-Chin Yin Yang-Chang Wu Chih-Hsin Tang |
| author_facet | Shan-Chi Liu Chun-Hao Tsai Tung-Ying Wu Chang-Hai Tsai Fuu-Jen Tsai Jing-Gung Chung Chih-Yang Huang Jai-Sing Yang Yuan-Man Hsu Mei-Chin Yin Yang-Chang Wu Chih-Hsin Tang |
| author_sort | Shan-Chi Liu |
| collection | DOAJ |
| description | Osteoarthritis (OA) commonly affects the synovial joint and is characterized by degradation of articular cartilage, which is largely mobilized by increased matrix metalloproteinase (MMP) activity. Soya-cerebroside, an extract of Cordyceps militaris, inhibits inflammatory cytokine production and monocyte migration in human synovial fibroblasts, although its effects are uncertain on MMP expression in chondrocytes and cartilage degradation. In this study, soya-cerebroside antagonized interleukin 1 beta (IL-1β)-induced MMP-1 production in chondrocytes, without cytotoxic effects. Functional genomic data confirm high levels of MMP-1 expression in OA tissue compared with normal tissue. Soya-cerebroside reduced MMP-1 expression via the focal adhesion kinase (FAK), mitogen-activated protein kinase (MEK), extracellular signal-regulated kinase (ERK) and AP-1 signalling pathways. In addition, soya-cerebroside suppressed IL-1β-promoted MMP-1 expression and cartilage degradation in animal models. Our report is the first to reveal that soya-cerebroside reduces MMP-1 production in chondrocytes and protects cartilage degradation through the FAK, MEK, ERK, and AP-1 signalling cascade. |
| first_indexed | 2024-12-21T02:01:24Z |
| format | Article |
| id | doaj.art-61f73e525f7c43b89324030667387df5 |
| institution | Directory Open Access Journal |
| issn | 0954-0105 1465-3443 |
| language | English |
| last_indexed | 2024-12-21T02:01:24Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Food and Agricultural Immunology |
| spelling | doaj.art-61f73e525f7c43b89324030667387df52022-12-21T19:19:37ZengTaylor & Francis GroupFood and Agricultural Immunology0954-01051465-34432019-01-0130162063210.1080/09540105.2019.16117451611745Soya-cerebroside reduces IL-1β-induced MMP-1 production in chondrocytes and inhibits cartilage degradation: implications for the treatment of osteoarthritisShan-Chi Liu0Chun-Hao Tsai1Tung-Ying Wu2Chang-Hai Tsai3Fuu-Jen Tsai4Jing-Gung Chung5Chih-Yang Huang6Jai-Sing Yang7Yuan-Man Hsu8Mei-Chin Yin9Yang-Chang Wu10Chih-Hsin Tang11School of Medicine, China Medical UniversityChina Medical UniversityChina Medical University HospitalChina Medical UniversityChina Medical UniversityChina Medical UniversityAsia UniversityChina Medical UniversityChina Medical UniversityChina Medical UniversityKaohsiung Medical UniversitySchool of Medicine, China Medical UniversityOsteoarthritis (OA) commonly affects the synovial joint and is characterized by degradation of articular cartilage, which is largely mobilized by increased matrix metalloproteinase (MMP) activity. Soya-cerebroside, an extract of Cordyceps militaris, inhibits inflammatory cytokine production and monocyte migration in human synovial fibroblasts, although its effects are uncertain on MMP expression in chondrocytes and cartilage degradation. In this study, soya-cerebroside antagonized interleukin 1 beta (IL-1β)-induced MMP-1 production in chondrocytes, without cytotoxic effects. Functional genomic data confirm high levels of MMP-1 expression in OA tissue compared with normal tissue. Soya-cerebroside reduced MMP-1 expression via the focal adhesion kinase (FAK), mitogen-activated protein kinase (MEK), extracellular signal-regulated kinase (ERK) and AP-1 signalling pathways. In addition, soya-cerebroside suppressed IL-1β-promoted MMP-1 expression and cartilage degradation in animal models. Our report is the first to reveal that soya-cerebroside reduces MMP-1 production in chondrocytes and protects cartilage degradation through the FAK, MEK, ERK, and AP-1 signalling cascade.http://dx.doi.org/10.1080/09540105.2019.1611745soya-cerebrosideosteoarthritischondrocytesil-1βmmp-1 |
| spellingShingle | Shan-Chi Liu Chun-Hao Tsai Tung-Ying Wu Chang-Hai Tsai Fuu-Jen Tsai Jing-Gung Chung Chih-Yang Huang Jai-Sing Yang Yuan-Man Hsu Mei-Chin Yin Yang-Chang Wu Chih-Hsin Tang Soya-cerebroside reduces IL-1β-induced MMP-1 production in chondrocytes and inhibits cartilage degradation: implications for the treatment of osteoarthritis Food and Agricultural Immunology soya-cerebroside osteoarthritis chondrocytes il-1β mmp-1 |
| title | Soya-cerebroside reduces IL-1β-induced MMP-1 production in chondrocytes and inhibits cartilage degradation: implications for the treatment of osteoarthritis |
| title_full | Soya-cerebroside reduces IL-1β-induced MMP-1 production in chondrocytes and inhibits cartilage degradation: implications for the treatment of osteoarthritis |
| title_fullStr | Soya-cerebroside reduces IL-1β-induced MMP-1 production in chondrocytes and inhibits cartilage degradation: implications for the treatment of osteoarthritis |
| title_full_unstemmed | Soya-cerebroside reduces IL-1β-induced MMP-1 production in chondrocytes and inhibits cartilage degradation: implications for the treatment of osteoarthritis |
| title_short | Soya-cerebroside reduces IL-1β-induced MMP-1 production in chondrocytes and inhibits cartilage degradation: implications for the treatment of osteoarthritis |
| title_sort | soya cerebroside reduces il 1β induced mmp 1 production in chondrocytes and inhibits cartilage degradation implications for the treatment of osteoarthritis |
| topic | soya-cerebroside osteoarthritis chondrocytes il-1β mmp-1 |
| url | http://dx.doi.org/10.1080/09540105.2019.1611745 |
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