Chemical Hypoxia Induces Pyroptosis in Neuronal Cells by Caspase-Dependent Gasdermin Activation

Chemical Hypoxia Induces Pyroptosis in Neuronal Cells by Caspase-Dependent Gasdermin Activation

Hypoxia-induced neuronal death is a major cause of neurodegenerative diseases. Pyroptosis is a type of inflammatory programmed cell death mediated by elevated intracellular levels of reactive oxygen species (ROS). Therefore, we hypothesized that hypoxia-induced ROS may trigger pyroptosis via caspase...

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Bibliographic Details
Main Authors: Chan Ho Park, Jun Young Park, Won Gil Cho
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
hypoxia
CoCl<sub>2</sub>
reactive oxygen species
gasdermin
pyroptosis
Online Access:https://www.mdpi.com/1422-0067/25/4/2185

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