Vitamina D y cáncer
Traditionally, vitamin D has been recognized as an endocrine hormone related mainly with calcium homeostasis. Nevertheless striking studies over the past decade have expanded this concept. Calcitriol the most active fono of the vitamin D is a molecule that exerts ample effects through genomic mecani...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universidad Nacional de Colombia
2001-04-01
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| Series: | Revista de la Facultad de Medicina |
| Subjects: | |
| Online Access: | https://revistas.unal.edu.co/index.php/revfacmed/article/view/19748 |
| Summary: | Traditionally, vitamin D has been recognized as an endocrine hormone related mainly with calcium homeostasis. Nevertheless striking studies over the past decade have expanded this concept. Calcitriol the most active fono of the vitamin D is a molecule that exerts ample effects through genomic mecanisms med.iated by the VDR, a receptor that belongs to the steroid-thyroid receptor superfamily; and through non-genomic mecanisms mediated by intracellular calcium-level regulation. Calcitriol is showing now as an important modulator of the irnmune response at various le veis and as an antiproliferative and differentiating promoting factor in a number of human tumoral cell lines. Nonetheless these antineoplasic effects documented in vitro models have been counteracted by the large hypercalcemic effect of the hormone observed in vivo, which makes its clinical application a rather difficult goal. Because of that, the development of calcitriol analogues with a diminished hypercalcemic effect that should result in new clinical alternatives in the management of hyperproliferative disorders such as psoriasis and some types of cancer, constitutes a notorious progress with important consequences for the medical practice. |
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| ISSN: | 0120-0011 2357-3848 |