Effect of Running Exercise on Oxidative Stress Biomarkers: A Systematic Review
Background: Exercise induced health benefits are limited by the overaccumulation of reactive oxygen species (ROS). ROS and further oxidative stress could potentially induce muscle damage which could result in poor exercise performance. However, predicting ROS induced oxidative stress in response to...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2020.610112/full |
| _version_ | 1818922997840347136 |
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| author | Anand Thirupathi Ricardo A. Pinho Ukadike C. Ugbolue Yuhuan He Yao Meng Yaodong Gu |
| author_facet | Anand Thirupathi Ricardo A. Pinho Ukadike C. Ugbolue Yuhuan He Yao Meng Yaodong Gu |
| author_sort | Anand Thirupathi |
| collection | DOAJ |
| description | Background: Exercise induced health benefits are limited by the overaccumulation of reactive oxygen species (ROS). ROS and further oxidative stress could potentially induce muscle damage which could result in poor exercise performance. However, predicting ROS induced oxidative stress in response to endurance training has several limitations in terms of selecting biomarkers that are used to measure oxidative stress.Objective: The purpose of this study was to systematically investigate the suitable biomarkers that predict oxidative stress status among runners.Methods: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, a search for relevant articles was carried out on PubMed/Medline, ISI Web of Science, and Google Scholar using related search terms such as oxidative damage, ROS, exercise, physical training, running, marathon, and ultramarathon.Results: Outcomes included (1) running programs like a half-marathon, ultramarathon, and iron-man race, (2) measuring biochemical assessment of oxidative damage markers such as malondialdehyde (MDA), protein carbonyl (PC), total antioxidant capacity (TAC), thiobarbituric acid reactive substances (TBARS), 8-Oxo-2'-deoxyguanosine (8-OH-dG), 4-hydroxynonenal (HNE), and F1-isoprostones, and enzymatic and non-enzymatic antioxidants level.Conclusions: This study concluded that a running exercise does not elicit a response to specific biomarkers of oxidative stress, instead, oxidative damage markers of lipids, proteins, and various enzymatic and non-enzymatic antioxidants are expressed according to the training status of the individual. |
| first_indexed | 2024-12-20T02:02:26Z |
| format | Article |
| id | doaj.art-61f8212c21594b04942c923479b7ecca |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-20T02:02:26Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-61f8212c21594b04942c923479b7ecca2022-12-21T19:57:17ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-01-011110.3389/fphys.2020.610112610112Effect of Running Exercise on Oxidative Stress Biomarkers: A Systematic ReviewAnand Thirupathi0Ricardo A. Pinho1Ukadike C. Ugbolue2Yuhuan He3Yao Meng4Yaodong Gu5Faculty of Sports Science, Ningbo University, Ningbo, ChinaLaboratory of Exercise Biochemistry in Health, Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, BrazilSchool of Health and Life Sciences, University of the West of Scotland, Scotland, United KingdomFaculty of Sports Science, Ningbo University, Ningbo, ChinaFaculty of Engineering, University of Szeged, Szeged, HungaryFaculty of Sports Science, Ningbo University, Ningbo, ChinaBackground: Exercise induced health benefits are limited by the overaccumulation of reactive oxygen species (ROS). ROS and further oxidative stress could potentially induce muscle damage which could result in poor exercise performance. However, predicting ROS induced oxidative stress in response to endurance training has several limitations in terms of selecting biomarkers that are used to measure oxidative stress.Objective: The purpose of this study was to systematically investigate the suitable biomarkers that predict oxidative stress status among runners.Methods: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, a search for relevant articles was carried out on PubMed/Medline, ISI Web of Science, and Google Scholar using related search terms such as oxidative damage, ROS, exercise, physical training, running, marathon, and ultramarathon.Results: Outcomes included (1) running programs like a half-marathon, ultramarathon, and iron-man race, (2) measuring biochemical assessment of oxidative damage markers such as malondialdehyde (MDA), protein carbonyl (PC), total antioxidant capacity (TAC), thiobarbituric acid reactive substances (TBARS), 8-Oxo-2'-deoxyguanosine (8-OH-dG), 4-hydroxynonenal (HNE), and F1-isoprostones, and enzymatic and non-enzymatic antioxidants level.Conclusions: This study concluded that a running exercise does not elicit a response to specific biomarkers of oxidative stress, instead, oxidative damage markers of lipids, proteins, and various enzymatic and non-enzymatic antioxidants are expressed according to the training status of the individual.https://www.frontiersin.org/articles/10.3389/fphys.2020.610112/fullrunningmarathonROSbiomarkersoxidative stressantioxidants |
| spellingShingle | Anand Thirupathi Ricardo A. Pinho Ukadike C. Ugbolue Yuhuan He Yao Meng Yaodong Gu Effect of Running Exercise on Oxidative Stress Biomarkers: A Systematic Review Frontiers in Physiology running marathon ROS biomarkers oxidative stress antioxidants |
| title | Effect of Running Exercise on Oxidative Stress Biomarkers: A Systematic Review |
| title_full | Effect of Running Exercise on Oxidative Stress Biomarkers: A Systematic Review |
| title_fullStr | Effect of Running Exercise on Oxidative Stress Biomarkers: A Systematic Review |
| title_full_unstemmed | Effect of Running Exercise on Oxidative Stress Biomarkers: A Systematic Review |
| title_short | Effect of Running Exercise on Oxidative Stress Biomarkers: A Systematic Review |
| title_sort | effect of running exercise on oxidative stress biomarkers a systematic review |
| topic | running marathon ROS biomarkers oxidative stress antioxidants |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2020.610112/full |
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