The Bul1/2 Alpha-Arrestins Promote Ubiquitylation and Endocytosis of the Can1 Permease upon Cycloheximide-Induced TORC1-Hyperactivation

The Bul1/2 Alpha-Arrestins Promote Ubiquitylation and Endocytosis of the Can1 Permease upon Cycloheximide-Induced TORC1-Hyperactivation

Selective endocytosis followed by degradation is a major mechanism for downregulating plasma membrane transporters in response to specific environmental cues. In <i>Saccharomyces cerevisiae,</i> this endocytosis is promoted by ubiquitylation catalyzed by the Rsp5 ubiquitin-ligase, target...

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Bibliographic Details
Main Authors: Amalia H. Megarioti, Cecilia Primo, George C. Kapetanakis, Alexandros Athanasopoulos, Vicky Sophianopoulou, Bruno André, Christos Gournas
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
ubiquitin
α-arrestin
endocytosis
transporter
arginine
Target of Rapamycin Complex 1
Online Access:https://www.mdpi.com/1422-0067/22/19/10208

Internet

https://www.mdpi.com/1422-0067/22/19/10208

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