Campylobacter jejuni subdural hygroma infection in a 2-year old boy: case report and a brief literature review
Abstract Background Campylobacter jejuni is a common cause of acute gastroenteritis, but central nervous system infections are rare manifestations of Campylobacter infection. Therefore, C. jejuni trauma-related subdural hygroma infection in children is poorly described in the literature. Case presen...
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-022-07680-0 |
| _version_ | 1811340352755335168 |
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| author | Ivana Valenčak-Ignjatić Nina Krajcar Diana Didović Srđan Roglić Iva Butić Marko Jelić Hrvoje Jednačak Goran Tešović |
| author_facet | Ivana Valenčak-Ignjatić Nina Krajcar Diana Didović Srđan Roglić Iva Butić Marko Jelić Hrvoje Jednačak Goran Tešović |
| author_sort | Ivana Valenčak-Ignjatić |
| collection | DOAJ |
| description | Abstract Background Campylobacter jejuni is a common cause of acute gastroenteritis, but central nervous system infections are rare manifestations of Campylobacter infection. Therefore, C. jejuni trauma-related subdural hygroma infection in children is poorly described in the literature. Case presentation We described a 2-year old boy with lobar holoprosencephaly presenting with subdural hygroma following head trauma. C. jejuni infection was confirmed from a subdural hygroma sample by culture as well as by DNA sequencing of a broad range 16S rDNA PCR product. Cerebrospinal fluid from the ventriculoperitoneal shunt remained sterile. Combined neurosurgical and antimicrobial treatment led to complete recovery. Review of the literature showed that the most common manifestation of Campylobacter central nervous system infection is meningitis, mostly in neonates, and subdural hygroma infection was described for only one case. Conclusions Subdural hygroma infection caused by C. jejuni is a rare clinical condition in children. Molecular methods represent an important tool for the detection of rare or unexpected pathogens. No standard recommendations for antimicrobial treatment of C. jejuni subdural space infection in children are available, but meropenem treatment combined with surgery seems to be an effective approach. |
| first_indexed | 2024-04-13T18:40:46Z |
| format | Article |
| id | doaj.art-61f9f6334df44379ababd26553203d88 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-13T18:40:46Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-61f9f6334df44379ababd26553203d882022-12-22T02:34:44ZengBMCBMC Infectious Diseases1471-23342022-08-012211710.1186/s12879-022-07680-0Campylobacter jejuni subdural hygroma infection in a 2-year old boy: case report and a brief literature reviewIvana Valenčak-Ignjatić0Nina Krajcar1Diana Didović2Srđan Roglić3Iva Butić4Marko Jelić5Hrvoje Jednačak6Goran Tešović7Pediatric Infectious Diseases Department, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”Pediatric Infectious Diseases Department, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”Pediatric Infectious Diseases Department, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”Pediatric Infectious Diseases Department, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”Pediatric Infectious Diseases Department, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”Pediatric Infectious Diseases Department, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”Department of Neurosurgery, University Hospital Centre ZagrebPediatric Infectious Diseases Department, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”Abstract Background Campylobacter jejuni is a common cause of acute gastroenteritis, but central nervous system infections are rare manifestations of Campylobacter infection. Therefore, C. jejuni trauma-related subdural hygroma infection in children is poorly described in the literature. Case presentation We described a 2-year old boy with lobar holoprosencephaly presenting with subdural hygroma following head trauma. C. jejuni infection was confirmed from a subdural hygroma sample by culture as well as by DNA sequencing of a broad range 16S rDNA PCR product. Cerebrospinal fluid from the ventriculoperitoneal shunt remained sterile. Combined neurosurgical and antimicrobial treatment led to complete recovery. Review of the literature showed that the most common manifestation of Campylobacter central nervous system infection is meningitis, mostly in neonates, and subdural hygroma infection was described for only one case. Conclusions Subdural hygroma infection caused by C. jejuni is a rare clinical condition in children. Molecular methods represent an important tool for the detection of rare or unexpected pathogens. No standard recommendations for antimicrobial treatment of C. jejuni subdural space infection in children are available, but meropenem treatment combined with surgery seems to be an effective approach.https://doi.org/10.1186/s12879-022-07680-0Campylobacter jejuniChildren16S rDNASubdural hygromaMeningitis |
| spellingShingle | Ivana Valenčak-Ignjatić Nina Krajcar Diana Didović Srđan Roglić Iva Butić Marko Jelić Hrvoje Jednačak Goran Tešović Campylobacter jejuni subdural hygroma infection in a 2-year old boy: case report and a brief literature review BMC Infectious Diseases Campylobacter jejuni Children 16S rDNA Subdural hygroma Meningitis |
| title | Campylobacter jejuni subdural hygroma infection in a 2-year old boy: case report and a brief literature review |
| title_full | Campylobacter jejuni subdural hygroma infection in a 2-year old boy: case report and a brief literature review |
| title_fullStr | Campylobacter jejuni subdural hygroma infection in a 2-year old boy: case report and a brief literature review |
| title_full_unstemmed | Campylobacter jejuni subdural hygroma infection in a 2-year old boy: case report and a brief literature review |
| title_short | Campylobacter jejuni subdural hygroma infection in a 2-year old boy: case report and a brief literature review |
| title_sort | campylobacter jejuni subdural hygroma infection in a 2 year old boy case report and a brief literature review |
| topic | Campylobacter jejuni Children 16S rDNA Subdural hygroma Meningitis |
| url | https://doi.org/10.1186/s12879-022-07680-0 |
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