The Effect of Trandolapril on Insulin Resistance is Determined by the Degree of Baseline Resistance Level
Insulin resistance (IR) is the core problem in type 2 diabetes mellitus that may lead to cardiovascular morbidity and mortality. Hypertension commonly accompanies type 2 diabetes. Antihypertensive agents improving IR may reduce the risk of cardiovascular diseases. This study was conducted to assess...
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| Format: | Article |
| Language: | English |
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Society of Turaz Bilim
2014-06-01
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| Series: | Medicine Science |
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| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=41583 |
| _version_ | 1827360498847318016 |
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| author | Canan Ersoy Alparslan Ersoy Gulsah Elbuken Ercan Tuncel |
| author_facet | Canan Ersoy Alparslan Ersoy Gulsah Elbuken Ercan Tuncel |
| author_sort | Canan Ersoy |
| collection | DOAJ |
| description | Insulin resistance (IR) is the core problem in type 2 diabetes mellitus that may lead to cardiovascular morbidity and mortality. Hypertension commonly accompanies type 2 diabetes. Antihypertensive agents improving IR may reduce the risk of cardiovascular diseases. This study was conducted to assess the effect of trandolapril on IR, glucose and lipid metabolisms in hypertensive subjects with different degrees of IR and investigate the importance of IR level in angiotensin converting enzyme inhibitor response. The subjects were nondiabetic and type 2 diabetic hypertensive patients treated with trandolapril for 12 weeks. Blood pressures (BP) and metabolic parameters were measured in all patients at baseline and after 12 weeks of trandolapril treatment and compared. Trandolapril reduced BP similarly in nondiabetic and diabetic patients. Homeostasis model assessment insulin resistance (HOMA-IR), serum glucose and hemoglobin A1C (A1C) in diabetic patients were higher than nondiabetics. HOMA-IR (from 9.0  1.0 to 6.6  0.7, p4.67 responded better. In conclusion, trandolapril improved insulin sensitivity better in type 2 diabetic hypertensive patients with higher degree of IR compared with the ones with low grade IR, being independent of its hemodynamic action. [Med-Science 2014; 3(2.000): 1140-54] |
| first_indexed | 2024-03-08T06:48:08Z |
| format | Article |
| id | doaj.art-61fa7e1235bd4547b678dbd6e5cd9ff2 |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T06:48:08Z |
| publishDate | 2014-06-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-61fa7e1235bd4547b678dbd6e5cd9ff22024-02-03T07:29:04ZengSociety of Turaz BilimMedicine Science2147-06342014-06-013211405410.5455/medscience.2013.02.811241583The Effect of Trandolapril on Insulin Resistance is Determined by the Degree of Baseline Resistance LevelCanan Ersoy0Alparslan ErsoyGulsah ElbukenErcan TuncelDivision of Endocrinology and Metabolism, Uludag University Medical Faculty, Bursa, Turkey Division of Nephrology, Uludag University Medical Faculty, Bursa, Turkey Division of Endocrinology and Metabolism, Tekirdag State Hospital, Tekirdag, TurkeyInsulin resistance (IR) is the core problem in type 2 diabetes mellitus that may lead to cardiovascular morbidity and mortality. Hypertension commonly accompanies type 2 diabetes. Antihypertensive agents improving IR may reduce the risk of cardiovascular diseases. This study was conducted to assess the effect of trandolapril on IR, glucose and lipid metabolisms in hypertensive subjects with different degrees of IR and investigate the importance of IR level in angiotensin converting enzyme inhibitor response. The subjects were nondiabetic and type 2 diabetic hypertensive patients treated with trandolapril for 12 weeks. Blood pressures (BP) and metabolic parameters were measured in all patients at baseline and after 12 weeks of trandolapril treatment and compared. Trandolapril reduced BP similarly in nondiabetic and diabetic patients. Homeostasis model assessment insulin resistance (HOMA-IR), serum glucose and hemoglobin A1C (A1C) in diabetic patients were higher than nondiabetics. HOMA-IR (from 9.0  1.0 to 6.6  0.7, p4.67 responded better. In conclusion, trandolapril improved insulin sensitivity better in type 2 diabetic hypertensive patients with higher degree of IR compared with the ones with low grade IR, being independent of its hemodynamic action. [Med-Science 2014; 3(2.000): 1140-54]http://www.ejmanager.com/fulltextpdf.php?mno=41583Trandolaprilinsulin resistancetype 2 diabetes mellitusglucoselipid |
| spellingShingle | Canan Ersoy Alparslan Ersoy Gulsah Elbuken Ercan Tuncel The Effect of Trandolapril on Insulin Resistance is Determined by the Degree of Baseline Resistance Level Medicine Science Trandolapril insulin resistance type 2 diabetes mellitus glucose lipid |
| title | The Effect of Trandolapril on Insulin Resistance is Determined by the Degree of Baseline Resistance Level |
| title_full | The Effect of Trandolapril on Insulin Resistance is Determined by the Degree of Baseline Resistance Level |
| title_fullStr | The Effect of Trandolapril on Insulin Resistance is Determined by the Degree of Baseline Resistance Level |
| title_full_unstemmed | The Effect of Trandolapril on Insulin Resistance is Determined by the Degree of Baseline Resistance Level |
| title_short | The Effect of Trandolapril on Insulin Resistance is Determined by the Degree of Baseline Resistance Level |
| title_sort | effect of trandolapril on insulin resistance is determined by the degree of baseline resistance level |
| topic | Trandolapril insulin resistance type 2 diabetes mellitus glucose lipid |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=41583 |
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