Endothelium and cardioprotectiv effects of HMG Co-A reductase in combination with L-arginin endotelial dysfunction in modeling
Using the combined of L-arginine with inhibitors of HMG-Co-A reductase simvastatin, atorvastatin, rosuvastatin and rosuvastatin nanopartikulirovannym on background modeling endotoxin-induced disease, the introduction of strain 603 Staphylococcusaureus shows endotelio- and cardioprotective effects, m...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2016-04-01
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| Series: | Кубанский научный медицинский вестник |
| Subjects: | |
| Online Access: | https://ksma.elpub.ru/jour/article/view/486 |
| _version_ | 1826568831729926144 |
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| author | T. A. Denisyuk M. V. Pokrovsky O. V. Filippova A. A. Dolzhikov T. G. Pokrovskaya M. V. Korokin O. A. Osipova A. I. Lazarev G. A. Lazareva |
| author_facet | T. A. Denisyuk M. V. Pokrovsky O. V. Filippova A. A. Dolzhikov T. G. Pokrovskaya M. V. Korokin O. A. Osipova A. I. Lazarev G. A. Lazareva |
| author_sort | T. A. Denisyuk |
| collection | DOAJ |
| description | Using the combined of L-arginine with inhibitors of HMG-Co-A reductase simvastatin, atorvastatin, rosuvastatin and rosuvastatin nanopartikulirovannym on background modeling endotoxin-induced disease, the introduction of strain 603 Staphylococcusaureus shows endotelio- and cardioprotective effects, manifested in preventing the proliferation coefficient of endothelial dysfunction (CED), adrenoreactivity, maintaining myocardial reserve and the normalization of the values of biochemical markers (Total NO, expression of eNOS, C-reactive protein, IL-6, TNF). Thus, combination therapy was so effective, that the values obtained in the combination therapy did not differ from those derived from control animals. |
| first_indexed | 2024-03-07T21:49:27Z |
| format | Article |
| id | doaj.art-61fcb77c1b614769add6c774c92140a1 |
| institution | Directory Open Access Journal |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| last_indexed | 2025-03-14T11:29:41Z |
| publishDate | 2016-04-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj.art-61fcb77c1b614769add6c774c92140a12025-03-02T10:05:27ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442016-04-0126467486Endothelium and cardioprotectiv effects of HMG Co-A reductase in combination with L-arginin endotelial dysfunction in modelingT. A. Denisyuk0M. V. Pokrovsky1O. V. Filippova2A. A. Dolzhikov3T. G. Pokrovskaya4M. V. Korokin5O. A. Osipova6A. I. Lazarev7G. A. Lazareva8FSAEI VPO «BSU»; SEI HPE KSMU of Russian ministry of healthFSAEI VPO «BSU»; SEI HPE KSMU of Russian ministry of healthFSAEI VPO «BSU»; SEI HPE KSMU of Russian ministry of healthFSAEI VPO «BSU»; SEI HPE KSMU of Russian ministry of healthFSAEI VPO «BSU»; SEI HPE KSMU of Russian ministry of healthFSAEI VPO «BSU»; SEI HPE KSMU of Russian ministry of healthFSAEI VPO «BSU»; SEI HPE KSMU of Russian ministry of healthFSAEI VPO «BSU»; SEI HPE KSMU of Russian ministry of healthFSAEI VPO «BSU»; SEI HPE KSMU of Russian ministry of healthUsing the combined of L-arginine with inhibitors of HMG-Co-A reductase simvastatin, atorvastatin, rosuvastatin and rosuvastatin nanopartikulirovannym on background modeling endotoxin-induced disease, the introduction of strain 603 Staphylococcusaureus shows endotelio- and cardioprotective effects, manifested in preventing the proliferation coefficient of endothelial dysfunction (CED), adrenoreactivity, maintaining myocardial reserve and the normalization of the values of biochemical markers (Total NO, expression of eNOS, C-reactive protein, IL-6, TNF). Thus, combination therapy was so effective, that the values obtained in the combination therapy did not differ from those derived from control animals.https://ksma.elpub.ru/jour/article/view/486эндотелиaльнaя дисфункцияингибиторы гмг-ко-а-редyктaзыэндотоксинl-nameendothelial dysfunctionhmg-co-a reductase inhibitorsendotoxinl-name |
| spellingShingle | T. A. Denisyuk M. V. Pokrovsky O. V. Filippova A. A. Dolzhikov T. G. Pokrovskaya M. V. Korokin O. A. Osipova A. I. Lazarev G. A. Lazareva Endothelium and cardioprotectiv effects of HMG Co-A reductase in combination with L-arginin endotelial dysfunction in modeling Кубанский научный медицинский вестник эндотелиaльнaя дисфункция ингибиторы гмг-ко-а-редyктaзы эндотоксин l-name endothelial dysfunction hmg-co-a reductase inhibitor sendotoxin l-name |
| title | Endothelium and cardioprotectiv effects of HMG Co-A reductase in combination with L-arginin endotelial dysfunction in modeling |
| title_full | Endothelium and cardioprotectiv effects of HMG Co-A reductase in combination with L-arginin endotelial dysfunction in modeling |
| title_fullStr | Endothelium and cardioprotectiv effects of HMG Co-A reductase in combination with L-arginin endotelial dysfunction in modeling |
| title_full_unstemmed | Endothelium and cardioprotectiv effects of HMG Co-A reductase in combination with L-arginin endotelial dysfunction in modeling |
| title_short | Endothelium and cardioprotectiv effects of HMG Co-A reductase in combination with L-arginin endotelial dysfunction in modeling |
| title_sort | endothelium and cardioprotectiv effects of hmg co a reductase in combination with l arginin endotelial dysfunction in modeling |
| topic | эндотелиaльнaя дисфункция ингибиторы гмг-ко-а-редyктaзы эндотоксин l-name endothelial dysfunction hmg-co-a reductase inhibitor sendotoxin l-name |
| url | https://ksma.elpub.ru/jour/article/view/486 |
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