Molecular and cellular parameters of ageing: an overview
Ageing is characterized by a progressive loss of physiological integrity, leading to impaired function and increased propensity to death. Ageing is an actively regulated metabolic process. This wear and tear is the primary risk factor for major human pathologies including diabetes, cancer, cardiovas...
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| Format: | Article |
| Language: | English |
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Al Ameen Medical College
2016-01-01
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| Series: | Al Ameen Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://ajms.alameenmedical.org/ArticlePDFs/3%20AJMS%20V9.N1.2016%20p%204-14.pdf |
| _version_ | 1828349089440333824 |
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| author | Himanshu Thukral Sumeet Soin Ritu Rani Aparna Sarkar |
| author_facet | Himanshu Thukral Sumeet Soin Ritu Rani Aparna Sarkar |
| author_sort | Himanshu Thukral |
| collection | DOAJ |
| description | Ageing is characterized by a progressive loss of physiological integrity, leading to impaired function and increased propensity to death. Ageing is an actively regulated metabolic process. This wear and tear is the primary risk factor for major human pathologies including diabetes, cancer, cardiovascular disorders, and neurodegenerative diseases. Approximately worldwide 1 lakh people die each day of age related causes. Ageing, which we define as the time-dependent functional decline that affects most living organisms, has attracted inquisitiveness and excited imagination throughout the history of mankind. Nowadays, ageing is subjected to scientific analysis based on the ever-expanding familiarity of the molecular and cellular basis of life and disease as specific genes have been recognized that regulate ageing. The time-dependent accretion of cellular damage is widely considered the general cause of ageing. In this study we tried to exemplify few parameters which regulates ageing and some pathways to increase life span or protecting mutation of cells into cancerous growth. |
| first_indexed | 2024-04-14T01:04:14Z |
| format | Article |
| id | doaj.art-61fe388bd92340bbb1f355a9d6742cb5 |
| institution | Directory Open Access Journal |
| issn | 0974-1143 0974-1143 |
| language | English |
| last_indexed | 2024-04-14T01:04:14Z |
| publishDate | 2016-01-01 |
| publisher | Al Ameen Medical College |
| record_format | Article |
| series | Al Ameen Journal of Medical Sciences |
| spelling | doaj.art-61fe388bd92340bbb1f355a9d6742cb52022-12-22T02:21:18ZengAl Ameen Medical CollegeAl Ameen Journal of Medical Sciences0974-11430974-11432016-01-010901414Molecular and cellular parameters of ageing: an overviewHimanshu Thukral0Sumeet Soin1Ritu Rani2Aparna Sarkar3Department of Physiology, Amity Institute of Physiology & Allied Sciences, Amity University, Uttar Pradesh, Sector-125, Noida-201303, IndiaDepartment of Physiology, Amity Institute of Physiology & Allied Sciences, Amity University, Uttar Pradesh, Sector-125, Noida-201303, IndiaDepartment of Physiology, Amity Institute of Physiology & Allied Sciences, Amity University, Uttar Pradesh, Sector-125, Noida-201303, IndiaDepartment of Physiology, Amity Institute of Physiology & Allied Sciences, Amity University, Uttar Pradesh, Sector-125, Noida-201303, IndiaAgeing is characterized by a progressive loss of physiological integrity, leading to impaired function and increased propensity to death. Ageing is an actively regulated metabolic process. This wear and tear is the primary risk factor for major human pathologies including diabetes, cancer, cardiovascular disorders, and neurodegenerative diseases. Approximately worldwide 1 lakh people die each day of age related causes. Ageing, which we define as the time-dependent functional decline that affects most living organisms, has attracted inquisitiveness and excited imagination throughout the history of mankind. Nowadays, ageing is subjected to scientific analysis based on the ever-expanding familiarity of the molecular and cellular basis of life and disease as specific genes have been recognized that regulate ageing. The time-dependent accretion of cellular damage is widely considered the general cause of ageing. In this study we tried to exemplify few parameters which regulates ageing and some pathways to increase life span or protecting mutation of cells into cancerous growth.http://ajms.alameenmedical.org/ArticlePDFs/3%20AJMS%20V9.N1.2016%20p%204-14.pdfAgeingApoptosisAutophagyReactive Oxygen Species (ROS) |
| spellingShingle | Himanshu Thukral Sumeet Soin Ritu Rani Aparna Sarkar Molecular and cellular parameters of ageing: an overview Al Ameen Journal of Medical Sciences Ageing Apoptosis Autophagy Reactive Oxygen Species (ROS) |
| title | Molecular and cellular parameters of ageing: an overview |
| title_full | Molecular and cellular parameters of ageing: an overview |
| title_fullStr | Molecular and cellular parameters of ageing: an overview |
| title_full_unstemmed | Molecular and cellular parameters of ageing: an overview |
| title_short | Molecular and cellular parameters of ageing: an overview |
| title_sort | molecular and cellular parameters of ageing an overview |
| topic | Ageing Apoptosis Autophagy Reactive Oxygen Species (ROS) |
| url | http://ajms.alameenmedical.org/ArticlePDFs/3%20AJMS%20V9.N1.2016%20p%204-14.pdf |
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