Reduced Carbohydrate Diet Influence on Postprandial Glycemia—Results of a Short, CGM-Based, Interventional Study in Adolescents with Type 1 Diabetes
Therapy for type 1 diabetes (T1DM) focuses on maintaining optimal blood glucose levels, achieved with intensive insulin treatment, proper nutrition, and physical activity. The aim of this study was to investigate postprandial glycemic changes under low (30%) and standard (50%) carbohydrate diets in...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/21/4689 |
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| author | Agnieszka Lejk Jędrzej Chrzanowski Adrianna Cieślak Wojciech Fendler Małgorzata Myśliwiec |
| author_facet | Agnieszka Lejk Jędrzej Chrzanowski Adrianna Cieślak Wojciech Fendler Małgorzata Myśliwiec |
| author_sort | Agnieszka Lejk |
| collection | DOAJ |
| description | Therapy for type 1 diabetes (T1DM) focuses on maintaining optimal blood glucose levels, achieved with intensive insulin treatment, proper nutrition, and physical activity. The aim of this study was to investigate postprandial glycemic changes under low (30%) and standard (50%) carbohydrate diets in adolescents with T1DM. A single-center cross-over nutritional study was conducted, during which 26 adolescent patients provided 220 continuous glucose-monitored (CGM) meals data from the two consecutive 3-day nutritional plans. Overall, the 50% carbohydrate diet was associated with higher postprandial glucose variability in the small meals (afternoon snacks, second breakfast) and greater postprandial peaks for other meals (breakfast, dinner, supper). Nevertheless, after the adjustment of a patient’s individual clinical variables (age, Tanner classification, glucose disposal rate), we observed that mean postprandial glucose was higher for afternoon snacks and lower for suppers in the 30% carbohydrate diet. Although a 30% carbohydrate diet seems to offer better postprandial glycemia, it requires additional attention from the physician and patient when it comes to modifying daily carbohydrate intake. Increased fat/protein content and size of the main meal lead to a prolonged postprandial glycemic response, which may affect the insulin treatment and result in suboptimal glycemic control. |
| first_indexed | 2024-03-09T18:45:59Z |
| format | Article |
| id | doaj.art-6200c9fc5b2f42898cbee355aa20c916 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T18:45:59Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-6200c9fc5b2f42898cbee355aa20c9162023-11-24T06:15:41ZengMDPI AGNutrients2072-66432022-11-011421468910.3390/nu14214689Reduced Carbohydrate Diet Influence on Postprandial Glycemia—Results of a Short, CGM-Based, Interventional Study in Adolescents with Type 1 DiabetesAgnieszka Lejk0Jędrzej Chrzanowski1Adrianna Cieślak2Wojciech Fendler3Małgorzata Myśliwiec4Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, 80-211 Gdansk, PolandDepartment of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, PolandDepartment of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, PolandDepartment of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, PolandDepartment of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, 80-211 Gdansk, PolandTherapy for type 1 diabetes (T1DM) focuses on maintaining optimal blood glucose levels, achieved with intensive insulin treatment, proper nutrition, and physical activity. The aim of this study was to investigate postprandial glycemic changes under low (30%) and standard (50%) carbohydrate diets in adolescents with T1DM. A single-center cross-over nutritional study was conducted, during which 26 adolescent patients provided 220 continuous glucose-monitored (CGM) meals data from the two consecutive 3-day nutritional plans. Overall, the 50% carbohydrate diet was associated with higher postprandial glucose variability in the small meals (afternoon snacks, second breakfast) and greater postprandial peaks for other meals (breakfast, dinner, supper). Nevertheless, after the adjustment of a patient’s individual clinical variables (age, Tanner classification, glucose disposal rate), we observed that mean postprandial glucose was higher for afternoon snacks and lower for suppers in the 30% carbohydrate diet. Although a 30% carbohydrate diet seems to offer better postprandial glycemia, it requires additional attention from the physician and patient when it comes to modifying daily carbohydrate intake. Increased fat/protein content and size of the main meal lead to a prolonged postprandial glycemic response, which may affect the insulin treatment and result in suboptimal glycemic control.https://www.mdpi.com/2072-6643/14/21/4689pediatric diabetescarbohydratesindividualized nutritional guideline |
| spellingShingle | Agnieszka Lejk Jędrzej Chrzanowski Adrianna Cieślak Wojciech Fendler Małgorzata Myśliwiec Reduced Carbohydrate Diet Influence on Postprandial Glycemia—Results of a Short, CGM-Based, Interventional Study in Adolescents with Type 1 Diabetes Nutrients pediatric diabetes carbohydrates individualized nutritional guideline |
| title | Reduced Carbohydrate Diet Influence on Postprandial Glycemia—Results of a Short, CGM-Based, Interventional Study in Adolescents with Type 1 Diabetes |
| title_full | Reduced Carbohydrate Diet Influence on Postprandial Glycemia—Results of a Short, CGM-Based, Interventional Study in Adolescents with Type 1 Diabetes |
| title_fullStr | Reduced Carbohydrate Diet Influence on Postprandial Glycemia—Results of a Short, CGM-Based, Interventional Study in Adolescents with Type 1 Diabetes |
| title_full_unstemmed | Reduced Carbohydrate Diet Influence on Postprandial Glycemia—Results of a Short, CGM-Based, Interventional Study in Adolescents with Type 1 Diabetes |
| title_short | Reduced Carbohydrate Diet Influence on Postprandial Glycemia—Results of a Short, CGM-Based, Interventional Study in Adolescents with Type 1 Diabetes |
| title_sort | reduced carbohydrate diet influence on postprandial glycemia results of a short cgm based interventional study in adolescents with type 1 diabetes |
| topic | pediatric diabetes carbohydrates individualized nutritional guideline |
| url | https://www.mdpi.com/2072-6643/14/21/4689 |
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