The Association between Prolonged Jaundice and TATA Box Dinucleotide Repeats in Gilbert’s Syndrome
Introduction: Jaundice is a common condition during the neonatal period. Prolonged jaundice occurs in a large number of breastfed infants, considering the impact of genetic factors on the incidence of jaundice. Aim: To determine the association between prolonged jaundice and TATA box dinucleoti...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/10597/19376_CE(RA1)_F(T)_PF1[MJ_AP]_PFA(MJ_GG)_PF2(MJ_SS)_PF3(SH_SS).pdf |
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| author | Yadollah Zahed Pasha Mousa Ahmadpor Kacho Haleh Akhavan Niaki Mehdi Tarighati Ehsan Alaee |
| author_facet | Yadollah Zahed Pasha Mousa Ahmadpor Kacho Haleh Akhavan Niaki Mehdi Tarighati Ehsan Alaee |
| author_sort | Yadollah Zahed Pasha |
| collection | DOAJ |
| description | Introduction: Jaundice is a common condition during the
neonatal period. Prolonged jaundice occurs in a large number
of breastfed infants, considering the impact of genetic factors
on the incidence of jaundice.
Aim: To determine the association between prolonged jaundice
and TATA box dinucleotide repeats in Gilbert’s Syndrome (GS).
Materials and Methods: In this case-control study, the case
group consisted of 51 neonates with jaundice, aged more than
two weeks with indirect bilirubin level higher than 10 mg/dl. Acute
diseases, mother’s use of phenobarbital and other medications
were the exclusion criteria. The control group consisted of 54
newborns without jaundice. The two groups were matched in
terms of age and sex. TATA box polymorphisms in the promoter
region of UGT1A1 gene were evaluated using Polymerase Chain
Reaction (PCR) in order to determine TATA box dinucleotide
repeats.
Results: Overall, 64.7% and 50% of subjects in the case and
control groups were male, respectively (p=0.168). The mean age
of neonates in the case and control groups was 20.1±7.1days
and 18.8±4.1 days, respectively. The distribution of Gilbert
genome was not significantly different between the two groups.
In the case group, 13.7% of the subjects were homozygous,
37.3% were heterozygous and 49% were normal. In the control
group, 7.4% of the participants were homozygous, 35.2% were
heterozygous and 57.4% were normal.
Conclusion: The results of this study showed an association
between TATA box polymorphism and prolonged jaundice in
neonates which revealed that TATA box polymorphism is an
important risk to increase and extend icterus. |
| first_indexed | 2024-12-11T08:08:37Z |
| format | Article |
| id | doaj.art-6200d90317d64b06b69b22afc4cc761d |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T08:08:37Z |
| publishDate | 2017-09-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-6200d90317d64b06b69b22afc4cc761d2022-12-22T01:14:57ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-09-01119GC05GC0710.7860/JCDR/2017/19376.10597The Association between Prolonged Jaundice and TATA Box Dinucleotide Repeats in Gilbert’s SyndromeYadollah Zahed Pasha0Mousa Ahmadpor Kacho1Haleh Akhavan Niaki2Mehdi Tarighati3Ehsan Alaee4Professor, Department of Paediatrics, Paediatric Research Center, Amirkola Children’s Hospital, School of Medicine, Babol University of Medical Sciences, Babol, Iran.Professor, Department of Paediatrics, Paediatric Research Center, Amirkola Children’s Hospital, School of Medicine, Babol University of Medical Sciences, Babol, Iran.Associate Professor, Department of Genetics, Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran.Staff Neonatologist, Department of Paediatrics, Paediatric Research Center, Amirkola Children’s Hospital, School of Medicine, Babol University of Medical Sciences, Babol, Iran. Assistant Professor, Department of Paediatrics, Neonatal and Children’s Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran.Introduction: Jaundice is a common condition during the neonatal period. Prolonged jaundice occurs in a large number of breastfed infants, considering the impact of genetic factors on the incidence of jaundice. Aim: To determine the association between prolonged jaundice and TATA box dinucleotide repeats in Gilbert’s Syndrome (GS). Materials and Methods: In this case-control study, the case group consisted of 51 neonates with jaundice, aged more than two weeks with indirect bilirubin level higher than 10 mg/dl. Acute diseases, mother’s use of phenobarbital and other medications were the exclusion criteria. The control group consisted of 54 newborns without jaundice. The two groups were matched in terms of age and sex. TATA box polymorphisms in the promoter region of UGT1A1 gene were evaluated using Polymerase Chain Reaction (PCR) in order to determine TATA box dinucleotide repeats. Results: Overall, 64.7% and 50% of subjects in the case and control groups were male, respectively (p=0.168). The mean age of neonates in the case and control groups was 20.1±7.1days and 18.8±4.1 days, respectively. The distribution of Gilbert genome was not significantly different between the two groups. In the case group, 13.7% of the subjects were homozygous, 37.3% were heterozygous and 49% were normal. In the control group, 7.4% of the participants were homozygous, 35.2% were heterozygous and 57.4% were normal. Conclusion: The results of this study showed an association between TATA box polymorphism and prolonged jaundice in neonates which revealed that TATA box polymorphism is an important risk to increase and extend icterus.https://jcdr.net/articles/PDF/10597/19376_CE(RA1)_F(T)_PF1[MJ_AP]_PFA(MJ_GG)_PF2(MJ_SS)_PF3(SH_SS).pdfindirect bilirubin levelmutationneonatalpolymorphismprolonged icter |
| spellingShingle | Yadollah Zahed Pasha Mousa Ahmadpor Kacho Haleh Akhavan Niaki Mehdi Tarighati Ehsan Alaee The Association between Prolonged Jaundice and TATA Box Dinucleotide Repeats in Gilbert’s Syndrome Journal of Clinical and Diagnostic Research indirect bilirubin level mutation neonatal polymorphism prolonged icter |
| title | The Association between Prolonged Jaundice and TATA Box Dinucleotide Repeats in Gilbert’s Syndrome |
| title_full | The Association between Prolonged Jaundice and TATA Box Dinucleotide Repeats in Gilbert’s Syndrome |
| title_fullStr | The Association between Prolonged Jaundice and TATA Box Dinucleotide Repeats in Gilbert’s Syndrome |
| title_full_unstemmed | The Association between Prolonged Jaundice and TATA Box Dinucleotide Repeats in Gilbert’s Syndrome |
| title_short | The Association between Prolonged Jaundice and TATA Box Dinucleotide Repeats in Gilbert’s Syndrome |
| title_sort | association between prolonged jaundice and tata box dinucleotide repeats in gilbert s syndrome |
| topic | indirect bilirubin level mutation neonatal polymorphism prolonged icter |
| url | https://jcdr.net/articles/PDF/10597/19376_CE(RA1)_F(T)_PF1[MJ_AP]_PFA(MJ_GG)_PF2(MJ_SS)_PF3(SH_SS).pdf |
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