Auditory Phenotype and Histopathologic Findings of a Mutant Nlrp3 Expression Mouse Model

Auditory Phenotype and Histopathologic Findings of a Mutant Nlrp3 Expression Mouse Model

ObjectiveThe pathogenesis of hearing loss in autoinflammatory disorders due to activation of the inflammasome remains incompletely understood. Previously no animals expressing mutant Nlrp3 (NOD-, LRR- and pyrin domain-containing protein 3) survived to an age when hearing evaluation was possible due...

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Bibliographic Details
Main Authors: Yehree Kim, Sang-Yeon Lee, Min Young Kim, Kyusun Park, Jin Hee Han, Jung Ho Kim, Bong Jik Kim, Byung Yoon Choi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Neurology
Subjects:
autoinflammatory inner ear disease
Nlrp3
inflammasome
hearing loss
Gfi1Cre
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.890256/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2022.890256/full

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