Anti-Restenotic Roles of Dihydroaustrasulfone Alcohol Involved in Inhibiting PDGF-BB-Stimulated Proliferation and Migration of Vascular Smooth Muscle Cells
Dihydroaustrasulfone alcohol (DA), an active compound firstly isolated from marine corals, has been reported to reveal anti-cancer and anti-inflammation activities. These reported activities of DA raised a possible application in anti-restenosis. Abnormal proliferation and migration of vascular smoo...
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| Format: | Article |
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MDPI AG
2015-05-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/13/5/3046 |
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| author | Pei-Chuan Li Ming-Jyh Sheu Wei-Fen Ma Chun-Hsu Pan Jyh-Horng Sheu Chieh-Hsi Wu |
| author_facet | Pei-Chuan Li Ming-Jyh Sheu Wei-Fen Ma Chun-Hsu Pan Jyh-Horng Sheu Chieh-Hsi Wu |
| author_sort | Pei-Chuan Li |
| collection | DOAJ |
| description | Dihydroaustrasulfone alcohol (DA), an active compound firstly isolated from marine corals, has been reported to reveal anti-cancer and anti-inflammation activities. These reported activities of DA raised a possible application in anti-restenosis. Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) and the stimulation of platelet-derived growth factor (PDGF)-BB play major pathological processes involved in the development of restenosis. Experimental results showed that DA markedly reduced balloon injury-induced neointima formation in the rat carotid artery model and significantly inhibited PDGF-BB-stimulated proliferation and migration of VSMCs. Our data further demonstrated that translational and active levels of several critical signaling cascades involved in VSMC proliferation, such as extracellular signal-regulated kinase/ mitogen-activated protein kinases (ERK/MAPK), phosphatidylinositol 3-kinase (PI3K)/AKT, and signal transducer and activator of transcription (STAT), were obviously inhibited. In addition, DA also decreased the activation and expression levels of gelatinases (matrix metalloproteinase (MMP)-2 and MMP-9) involved in cell migration. In conclusion, our findings indicate that DA can reduce balloon injury-neointimal hyperplasia, the effect of which may be modulated through suppression of VSMC proliferation and migration. These results suggest that DA has potential application as an anti-restenotic agent for the prevention of restenosis. |
| first_indexed | 2024-04-11T14:08:01Z |
| format | Article |
| id | doaj.art-62049814dda04303aa58f83a7cc66b27 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T14:08:01Z |
| publishDate | 2015-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-62049814dda04303aa58f83a7cc66b272022-12-22T04:19:48ZengMDPI AGMarine Drugs1660-33972015-05-011353046306010.3390/md13053046md13053046Anti-Restenotic Roles of Dihydroaustrasulfone Alcohol Involved in Inhibiting PDGF-BB-Stimulated Proliferation and Migration of Vascular Smooth Muscle CellsPei-Chuan Li0Ming-Jyh Sheu1Wei-Fen Ma2Chun-Hsu Pan3Jyh-Horng Sheu4Chieh-Hsi Wu5Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USASchool of Pharmacy, China Medical University, Taichung 404, TaiwanSchool of Nursing, China Medical University, Taichung 404, TaiwanDepartment of Pharmacy, Taipei Medical University, Taipei 110, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanSchool of Pharmacy, China Medical University, Taichung 404, TaiwanDihydroaustrasulfone alcohol (DA), an active compound firstly isolated from marine corals, has been reported to reveal anti-cancer and anti-inflammation activities. These reported activities of DA raised a possible application in anti-restenosis. Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) and the stimulation of platelet-derived growth factor (PDGF)-BB play major pathological processes involved in the development of restenosis. Experimental results showed that DA markedly reduced balloon injury-induced neointima formation in the rat carotid artery model and significantly inhibited PDGF-BB-stimulated proliferation and migration of VSMCs. Our data further demonstrated that translational and active levels of several critical signaling cascades involved in VSMC proliferation, such as extracellular signal-regulated kinase/ mitogen-activated protein kinases (ERK/MAPK), phosphatidylinositol 3-kinase (PI3K)/AKT, and signal transducer and activator of transcription (STAT), were obviously inhibited. In addition, DA also decreased the activation and expression levels of gelatinases (matrix metalloproteinase (MMP)-2 and MMP-9) involved in cell migration. In conclusion, our findings indicate that DA can reduce balloon injury-neointimal hyperplasia, the effect of which may be modulated through suppression of VSMC proliferation and migration. These results suggest that DA has potential application as an anti-restenotic agent for the prevention of restenosis.http://www.mdpi.com/1660-3397/13/5/3046dihydroaustrasulfone alcoholanti-restenosisneointimal hyperplasiamarine origin |
| spellingShingle | Pei-Chuan Li Ming-Jyh Sheu Wei-Fen Ma Chun-Hsu Pan Jyh-Horng Sheu Chieh-Hsi Wu Anti-Restenotic Roles of Dihydroaustrasulfone Alcohol Involved in Inhibiting PDGF-BB-Stimulated Proliferation and Migration of Vascular Smooth Muscle Cells Marine Drugs dihydroaustrasulfone alcohol anti-restenosis neointimal hyperplasia marine origin |
| title | Anti-Restenotic Roles of Dihydroaustrasulfone Alcohol Involved in Inhibiting PDGF-BB-Stimulated Proliferation and Migration of Vascular Smooth Muscle Cells |
| title_full | Anti-Restenotic Roles of Dihydroaustrasulfone Alcohol Involved in Inhibiting PDGF-BB-Stimulated Proliferation and Migration of Vascular Smooth Muscle Cells |
| title_fullStr | Anti-Restenotic Roles of Dihydroaustrasulfone Alcohol Involved in Inhibiting PDGF-BB-Stimulated Proliferation and Migration of Vascular Smooth Muscle Cells |
| title_full_unstemmed | Anti-Restenotic Roles of Dihydroaustrasulfone Alcohol Involved in Inhibiting PDGF-BB-Stimulated Proliferation and Migration of Vascular Smooth Muscle Cells |
| title_short | Anti-Restenotic Roles of Dihydroaustrasulfone Alcohol Involved in Inhibiting PDGF-BB-Stimulated Proliferation and Migration of Vascular Smooth Muscle Cells |
| title_sort | anti restenotic roles of dihydroaustrasulfone alcohol involved in inhibiting pdgf bb stimulated proliferation and migration of vascular smooth muscle cells |
| topic | dihydroaustrasulfone alcohol anti-restenosis neointimal hyperplasia marine origin |
| url | http://www.mdpi.com/1660-3397/13/5/3046 |
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