Effectiveness of vortioxetine for winter depression in bipolar disorder: A case report
Abstract Background We present a case report on the efficacy of the short‐term application of vortioxetine in managing winter depression in patients with seasonal bipolar disorder (BP). Standard treatment strategies for BP may not adequately address seasonal depressive symptoms during winter in pati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | PCN Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/pcn5.163 |
| _version_ | 1797244699405189120 |
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| author | Yusei Yamaguchi Shunsuke Takagi Hidehiko Takahashi Genichi Sugihara |
| author_facet | Yusei Yamaguchi Shunsuke Takagi Hidehiko Takahashi Genichi Sugihara |
| author_sort | Yusei Yamaguchi |
| collection | DOAJ |
| description | Abstract Background We present a case report on the efficacy of the short‐term application of vortioxetine in managing winter depression in patients with seasonal bipolar disorder (BP). Standard treatment strategies for BP may not adequately address seasonal depressive symptoms during winter in patients with seasonal BP patterns. Depressive symptoms during winter may be linked to seasonal changes in serotonin transporter binding, such as a decrease in synaptic serotonin levels, necessitating alternative approaches. Although antidepressants, including vortioxetine, are effective in treating seasonal monopolar depression, their efficacy and safety in treating depression in patients with seasonal BP patterns remain unclear. Case Presentation This case report focuses on a 44‐year‐old male patient diagnosed with seasonal BP who had recurrent depressive episodes, specifically during winter. Notably, the patient had a significant decrease in recurrent episodes after short‐term seasonal vortioxetine use without inducing mania or rapid cycling. Conclusion Our study highlights the potential effectiveness of a seasonal, short‐term treatment strategy with antidepressants, including vortioxetine, for winter depression in individuals with BP. |
| first_indexed | 2024-04-24T19:15:10Z |
| format | Article |
| id | doaj.art-6206e7314f464624b12978949416d741 |
| institution | Directory Open Access Journal |
| issn | 2769-2558 |
| language | English |
| last_indexed | 2024-04-24T19:15:10Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | PCN Reports |
| spelling | doaj.art-6206e7314f464624b12978949416d7412024-03-26T07:48:27ZengWileyPCN Reports2769-25582024-03-0131n/an/a10.1002/pcn5.163Effectiveness of vortioxetine for winter depression in bipolar disorder: A case reportYusei Yamaguchi0Shunsuke Takagi1Hidehiko Takahashi2Genichi Sugihara3Department of Psychiatry and Behavioral Sciences Tokyo Medical and Dental University Graduate School Tokyo JapanDepartment of Psychiatry and Behavioral Sciences Tokyo Medical and Dental University Graduate School Tokyo JapanDepartment of Psychiatry and Behavioral Sciences Tokyo Medical and Dental University Graduate School Tokyo JapanDepartment of Psychiatry and Behavioral Sciences Tokyo Medical and Dental University Graduate School Tokyo JapanAbstract Background We present a case report on the efficacy of the short‐term application of vortioxetine in managing winter depression in patients with seasonal bipolar disorder (BP). Standard treatment strategies for BP may not adequately address seasonal depressive symptoms during winter in patients with seasonal BP patterns. Depressive symptoms during winter may be linked to seasonal changes in serotonin transporter binding, such as a decrease in synaptic serotonin levels, necessitating alternative approaches. Although antidepressants, including vortioxetine, are effective in treating seasonal monopolar depression, their efficacy and safety in treating depression in patients with seasonal BP patterns remain unclear. Case Presentation This case report focuses on a 44‐year‐old male patient diagnosed with seasonal BP who had recurrent depressive episodes, specifically during winter. Notably, the patient had a significant decrease in recurrent episodes after short‐term seasonal vortioxetine use without inducing mania or rapid cycling. Conclusion Our study highlights the potential effectiveness of a seasonal, short‐term treatment strategy with antidepressants, including vortioxetine, for winter depression in individuals with BP.https://doi.org/10.1002/pcn5.163SADseasonal affective disorderSSRIwinter depressionvortioxetine |
| spellingShingle | Yusei Yamaguchi Shunsuke Takagi Hidehiko Takahashi Genichi Sugihara Effectiveness of vortioxetine for winter depression in bipolar disorder: A case report PCN Reports SAD seasonal affective disorder SSRI winter depression vortioxetine |
| title | Effectiveness of vortioxetine for winter depression in bipolar disorder: A case report |
| title_full | Effectiveness of vortioxetine for winter depression in bipolar disorder: A case report |
| title_fullStr | Effectiveness of vortioxetine for winter depression in bipolar disorder: A case report |
| title_full_unstemmed | Effectiveness of vortioxetine for winter depression in bipolar disorder: A case report |
| title_short | Effectiveness of vortioxetine for winter depression in bipolar disorder: A case report |
| title_sort | effectiveness of vortioxetine for winter depression in bipolar disorder a case report |
| topic | SAD seasonal affective disorder SSRI winter depression vortioxetine |
| url | https://doi.org/10.1002/pcn5.163 |
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