Atypical Goodpasture’s disease: a clinical case report and literature review
Goodpasture’s disease (anti-GBM disease) is a rare small vessels vasculitis characterized by the presence of autoantibodies directed against the glomerular basement membrane (GBM) and alveolar basement membrane. Common feature of anti-GBM disease is a combination of rapidly progressive glomeruloneph...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2018-06-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/32816/pdf |
| _version_ | 1818174546292768768 |
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| author | M L Bulanova D V Potapov N M Bulanov L V Lysenko(Kozlovskaya) |
| author_facet | M L Bulanova D V Potapov N M Bulanov L V Lysenko(Kozlovskaya) |
| author_sort | M L Bulanova |
| collection | DOAJ |
| description | Goodpasture’s disease (anti-GBM disease) is a rare small vessels vasculitis characterized by the presence of autoantibodies directed against the glomerular basement membrane (GBM) and alveolar basement membrane. Common feature of anti-GBM disease is a combination of rapidly progressive glomerulonephritis and alveolar hemorrhage (pulmonary-renal syndrome). We present a case of atypical disease course in a young male patient who developed alveolar hemorrhage without renal failure. The only symptom of renal involvement was isolated hematuria. Plasmapheresis combined with immunosuppression (cyclophosphamide and corticosteroids) was effective. We present a review of state-of-art data on the pathogenesis and disease course of anti-GBM disease. |
| first_indexed | 2024-12-11T19:46:07Z |
| format | Article |
| id | doaj.art-620997d7db8c4f909fc362a0f46f05ae |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-11T19:46:07Z |
| publishDate | 2018-06-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-620997d7db8c4f909fc362a0f46f05ae2022-12-22T00:52:54Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422018-06-0190613013610.26442/terarkh2018906130-13629568Atypical Goodpasture’s disease: a clinical case report and literature reviewM L Bulanova0D V Potapov1N M Bulanov2L V Lysenko(Kozlovskaya)3Vladimir Regional Clinical HospitalVladimir Regional Clinical HospitalI.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)Goodpasture’s disease (anti-GBM disease) is a rare small vessels vasculitis characterized by the presence of autoantibodies directed against the glomerular basement membrane (GBM) and alveolar basement membrane. Common feature of anti-GBM disease is a combination of rapidly progressive glomerulonephritis and alveolar hemorrhage (pulmonary-renal syndrome). We present a case of atypical disease course in a young male patient who developed alveolar hemorrhage without renal failure. The only symptom of renal involvement was isolated hematuria. Plasmapheresis combined with immunosuppression (cyclophosphamide and corticosteroids) was effective. We present a review of state-of-art data on the pathogenesis and disease course of anti-GBM disease.https://ter-arkhiv.ru/0040-3660/article/viewFile/32816/pdfgoodpasture’s diseaseanti-gbm diseaseanti-glomerular basement membrane antibodiespulmonary hemorrhageplasmapheresis |
| spellingShingle | M L Bulanova D V Potapov N M Bulanov L V Lysenko(Kozlovskaya) Atypical Goodpasture’s disease: a clinical case report and literature review Терапевтический архив goodpasture’s disease anti-gbm disease anti-glomerular basement membrane antibodies pulmonary hemorrhage plasmapheresis |
| title | Atypical Goodpasture’s disease: a clinical case report and literature review |
| title_full | Atypical Goodpasture’s disease: a clinical case report and literature review |
| title_fullStr | Atypical Goodpasture’s disease: a clinical case report and literature review |
| title_full_unstemmed | Atypical Goodpasture’s disease: a clinical case report and literature review |
| title_short | Atypical Goodpasture’s disease: a clinical case report and literature review |
| title_sort | atypical goodpasture s disease a clinical case report and literature review |
| topic | goodpasture’s disease anti-gbm disease anti-glomerular basement membrane antibodies pulmonary hemorrhage plasmapheresis |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/32816/pdf |
| work_keys_str_mv | AT mlbulanova atypicalgoodpasturesdiseaseaclinicalcasereportandliteraturereview AT dvpotapov atypicalgoodpasturesdiseaseaclinicalcasereportandliteraturereview AT nmbulanov atypicalgoodpasturesdiseaseaclinicalcasereportandliteraturereview AT lvlysenkokozlovskaya atypicalgoodpasturesdiseaseaclinicalcasereportandliteraturereview |