Correlation of Human Papillomavirus Infection with Esophageal Squamous Cell Carcinoma
BACKGROUND AND OBJECTIVE: Human Papillomavirus (HPV) plays an important role in the genesis of cancers of cervix and oral cavity. Squamous epithelium of esophagus is an appropriate site for HPV infection. The aim of this study was to determine the correlation of this infection with esophageal squamo...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2011-07-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| Subjects: | |
| Online Access: | http://jbums.org/article-1-3843-en.html |
| _version_ | 1819012391849951232 |
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| author | O Emadian F Naghshvar AR Rafiei E Maleki J Torabizadeh Rezaei Far |
| author_facet | O Emadian F Naghshvar AR Rafiei E Maleki J Torabizadeh Rezaei Far |
| author_sort | O Emadian |
| collection | DOAJ |
| description | BACKGROUND AND OBJECTIVE: Human Papillomavirus (HPV) plays an important role in the genesis of cancers of cervix and oral cavity. Squamous epithelium of esophagus is an appropriate site for HPV infection. The aim of this study was to determine the correlation of this infection with esophageal squamous cell carcinoma (ESCC).METHODS: In a case-control study forty cases of ESCC and forty controls with nonmalignant specimens from the patients referred to Imam Khomeini hospital–Sari (Mazandaran, Iran) during eight years (2001-2008) were enrolled. Extracted DNAs from the specimens were analyzed for HPV DNA with the commercial kits available for HPV.FINDINGS: Fifteen (37.5%) cases of ESCC and 5 (12.5%) specimens of controls were positive for HPV DNA (p=0.03). The most common genotypes in the ESCC patients and control group were HPV16 & HPV45 (each 15% for ESCC patients HPV16 7.5% and HPV45 five percent for the controls). There was no significant difference for HPV genotype and patient’s age, sex or tumor’s stage and grade.CONCLUSION: HPV may be counted as an important risk factor for ESCC in northern region of Iran. |
| first_indexed | 2024-12-21T01:43:19Z |
| format | Article |
| id | doaj.art-6209983a1e8d47ccba52dd5b0558bf28 |
| institution | Directory Open Access Journal |
| issn | 1561-4107 2251-7170 |
| language | English |
| last_indexed | 2024-12-21T01:43:19Z |
| publishDate | 2011-07-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| spelling | doaj.art-6209983a1e8d47ccba52dd5b0558bf282022-12-21T19:20:05ZengBabol University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul1561-41072251-71702011-07-011345459Correlation of Human Papillomavirus Infection with Esophageal Squamous Cell CarcinomaO Emadian0F Naghshvar1AR Rafiei2E Maleki3J Torabizadeh4Rezaei Far5 BACKGROUND AND OBJECTIVE: Human Papillomavirus (HPV) plays an important role in the genesis of cancers of cervix and oral cavity. Squamous epithelium of esophagus is an appropriate site for HPV infection. The aim of this study was to determine the correlation of this infection with esophageal squamous cell carcinoma (ESCC).METHODS: In a case-control study forty cases of ESCC and forty controls with nonmalignant specimens from the patients referred to Imam Khomeini hospital–Sari (Mazandaran, Iran) during eight years (2001-2008) were enrolled. Extracted DNAs from the specimens were analyzed for HPV DNA with the commercial kits available for HPV.FINDINGS: Fifteen (37.5%) cases of ESCC and 5 (12.5%) specimens of controls were positive for HPV DNA (p=0.03). The most common genotypes in the ESCC patients and control group were HPV16 & HPV45 (each 15% for ESCC patients HPV16 7.5% and HPV45 five percent for the controls). There was no significant difference for HPV genotype and patient’s age, sex or tumor’s stage and grade.CONCLUSION: HPV may be counted as an important risk factor for ESCC in northern region of Iran.http://jbums.org/article-1-3843-en.htmlhuman papillomavirusesesophageal squamous cell carcinomapolymerase chain reaction (pcr) |
| spellingShingle | O Emadian F Naghshvar AR Rafiei E Maleki J Torabizadeh Rezaei Far Correlation of Human Papillomavirus Infection with Esophageal Squamous Cell Carcinoma Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul human papillomaviruses esophageal squamous cell carcinoma polymerase chain reaction (pcr) |
| title | Correlation of Human Papillomavirus Infection with Esophageal Squamous Cell Carcinoma |
| title_full | Correlation of Human Papillomavirus Infection with Esophageal Squamous Cell Carcinoma |
| title_fullStr | Correlation of Human Papillomavirus Infection with Esophageal Squamous Cell Carcinoma |
| title_full_unstemmed | Correlation of Human Papillomavirus Infection with Esophageal Squamous Cell Carcinoma |
| title_short | Correlation of Human Papillomavirus Infection with Esophageal Squamous Cell Carcinoma |
| title_sort | correlation of human papillomavirus infection with esophageal squamous cell carcinoma |
| topic | human papillomaviruses esophageal squamous cell carcinoma polymerase chain reaction (pcr) |
| url | http://jbums.org/article-1-3843-en.html |
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