Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID‐19
Abstract Cognitive post‐acute sequelae of SARS‐CoV‐2 (PASC) can occur after mild COVID‐19. Detailed clinical characterizations may inform pathogenesis. We evaluated 22 adults reporting cognitive PASC and 10 not reporting cognitive symptoms after mild SARS‐CoV‐2 infection through structured interview...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-02-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51498 |
| _version_ | 1819278254643609600 |
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| author | Alexandra C. Apple Alexis Oddi Michael J. Peluso Breton M. Asken Timothy J. Henrich J. Daniel Kelly Samuel J. Pleasure Steven G. Deeks Isabel Elaine Allen Jeffrey N. Martin Lishomwa C. Ndhlovu Bruce L. Miller Melanie L. Stephens Joanna Hellmuth |
| author_facet | Alexandra C. Apple Alexis Oddi Michael J. Peluso Breton M. Asken Timothy J. Henrich J. Daniel Kelly Samuel J. Pleasure Steven G. Deeks Isabel Elaine Allen Jeffrey N. Martin Lishomwa C. Ndhlovu Bruce L. Miller Melanie L. Stephens Joanna Hellmuth |
| author_sort | Alexandra C. Apple |
| collection | DOAJ |
| description | Abstract Cognitive post‐acute sequelae of SARS‐CoV‐2 (PASC) can occur after mild COVID‐19. Detailed clinical characterizations may inform pathogenesis. We evaluated 22 adults reporting cognitive PASC and 10 not reporting cognitive symptoms after mild SARS‐CoV‐2 infection through structured interviews, neuropsychological testing, and optional cerebrospinal fluid (CSF) evaluations (53%). Delayed onset of cognitive PASC occurred in 43% and associated with younger age. Cognitive PASC participants had a higher number of pre‐existing cognitive risk factors (2.5 vs. 0; p = 0.03) and higher proportion with abnormal CSF findings (77% vs. 0%; p = 0.01) versus controls. Cognitive risk factors and immunologic mechanisms may contribute to cognitive PASC pathogenesis. |
| first_indexed | 2024-12-24T00:09:05Z |
| format | Article |
| id | doaj.art-620a0a5200db42258e253d634dbda614 |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-12-24T00:09:05Z |
| publishDate | 2022-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-620a0a5200db42258e253d634dbda6142022-12-21T17:24:55ZengWileyAnnals of Clinical and Translational Neurology2328-95032022-02-019222122610.1002/acn3.51498Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID‐19Alexandra C. Apple0Alexis Oddi1Michael J. Peluso2Breton M. Asken3Timothy J. Henrich4J. Daniel Kelly5Samuel J. Pleasure6Steven G. Deeks7Isabel Elaine Allen8Jeffrey N. Martin9Lishomwa C. Ndhlovu10Bruce L. Miller11Melanie L. Stephens12Joanna Hellmuth13Department of Neurology, Memory and Aging Center University of California, San Francisco San Francisco California USADepartment of Neurology, Memory and Aging Center University of California, San Francisco San Francisco California USADivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine University of California, San Francisco San Francisco California USADepartment of Neurology, Memory and Aging Center University of California, San Francisco San Francisco California USADivision of Experimental Medicine, Department of Medicine University of California, San Francisco San Francisco California USADepartment of Epidemiology & Biostatistics University of California, San Francisco San Francisco California USADepartment of Neurology, Weill Institute for Neurosciences University of California, San Francisco San Francisco California USADivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine University of California, San Francisco San Francisco California USADepartment of Epidemiology & Biostatistics University of California, San Francisco San Francisco California USADepartment of Epidemiology & Biostatistics University of California, San Francisco San Francisco California USADivision of Infectious Disease, Department of Medicine Weill Cornell Medicine New York New York USADepartment of Neurology, Memory and Aging Center University of California, San Francisco San Francisco California USADepartment of Neurology, Memory and Aging Center University of California, San Francisco San Francisco California USADepartment of Neurology, Memory and Aging Center University of California, San Francisco San Francisco California USAAbstract Cognitive post‐acute sequelae of SARS‐CoV‐2 (PASC) can occur after mild COVID‐19. Detailed clinical characterizations may inform pathogenesis. We evaluated 22 adults reporting cognitive PASC and 10 not reporting cognitive symptoms after mild SARS‐CoV‐2 infection through structured interviews, neuropsychological testing, and optional cerebrospinal fluid (CSF) evaluations (53%). Delayed onset of cognitive PASC occurred in 43% and associated with younger age. Cognitive PASC participants had a higher number of pre‐existing cognitive risk factors (2.5 vs. 0; p = 0.03) and higher proportion with abnormal CSF findings (77% vs. 0%; p = 0.01) versus controls. Cognitive risk factors and immunologic mechanisms may contribute to cognitive PASC pathogenesis.https://doi.org/10.1002/acn3.51498 |
| spellingShingle | Alexandra C. Apple Alexis Oddi Michael J. Peluso Breton M. Asken Timothy J. Henrich J. Daniel Kelly Samuel J. Pleasure Steven G. Deeks Isabel Elaine Allen Jeffrey N. Martin Lishomwa C. Ndhlovu Bruce L. Miller Melanie L. Stephens Joanna Hellmuth Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID‐19 Annals of Clinical and Translational Neurology |
| title | Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID‐19 |
| title_full | Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID‐19 |
| title_fullStr | Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID‐19 |
| title_full_unstemmed | Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID‐19 |
| title_short | Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID‐19 |
| title_sort | risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild covid 19 |
| url | https://doi.org/10.1002/acn3.51498 |
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