Melatonin inhibited the progression of gastric cancer induced by Bisphenol S via regulating the estrogen receptor 1
In recent years, Bisphenol S (BPS) has increasingly been used as an alternative to Bisphenol A (BPA) in food, paper, and personal care products. It is imperative to clarify the relationship between BPS and tumors in order to treat and prevent diseases. This study discovered a new method for predicti...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323005584 |
| _version_ | 1797812797796515840 |
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| author | Yi Wang Jintian Song Yangming Li Chen Lin Yan Chen Xu Zhang Hui Yu |
| author_facet | Yi Wang Jintian Song Yangming Li Chen Lin Yan Chen Xu Zhang Hui Yu |
| author_sort | Yi Wang |
| collection | DOAJ |
| description | In recent years, Bisphenol S (BPS) has increasingly been used as an alternative to Bisphenol A (BPA) in food, paper, and personal care products. It is imperative to clarify the relationship between BPS and tumors in order to treat and prevent diseases. This study discovered a new method for predicting tumor correlations between BPS interactive genes. According to analyses conducted by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes, interactive genes were primarily found in gastric cancer. Based on gene-targeted prediction and molecular docking, BPS appears to exert potential gastric cancer-causing effects through estrogen receptor 1 (ESR1). In addition, gastric cancer patients' prognosis could be accurately predicted by a bisphenol-based prognostic prediction model. Subsequently, the proliferation and migration abilities of gastric cancer cells were further demonstrated to be significantly enhanced by BPS. Similarly, molecular docking analysis revealed that melatonin is also highly correlated with gastric cancer and BPS. In cell proliferation and migration assays, melatonin and BPS exposure inhibited the invasion abilities of gastric cancer cells compared to BPS-exposure. Our research provided a new direction for the exploration the correlation between cancer and environmental toxicity. |
| first_indexed | 2024-03-13T07:43:46Z |
| format | Article |
| id | doaj.art-620bbf410d25499bb7669a9aa562accb |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-13T07:43:46Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-620bbf410d25499bb7669a9aa562accb2023-06-03T04:21:36ZengElsevierEcotoxicology and Environmental Safety0147-65132023-07-01259115054Melatonin inhibited the progression of gastric cancer induced by Bisphenol S via regulating the estrogen receptor 1Yi Wang0Jintian Song1Yangming Li2Chen Lin3Yan Chen4Xu Zhang5Hui Yu6Department of Gastrointestinal Surgical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350000, Fujian Province, ChinaDepartment of Abdominal Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350000, Fujian Province, ChinaDepartment of Gastrointestinal Surgical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350000, Fujian Province, ChinaSchool of Pharmacy, Fujian Medical University, Fuzhou 350000, Fujian Province, ChinaSchool of Pharmacy, Fujian Medical University, Fuzhou 350000, Fujian Province, ChinaNanjing Medical University, Nanjing, 210029, ChinaDepartment of Pharmacy, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350000, Fujian Province, China; Corresponding author.In recent years, Bisphenol S (BPS) has increasingly been used as an alternative to Bisphenol A (BPA) in food, paper, and personal care products. It is imperative to clarify the relationship between BPS and tumors in order to treat and prevent diseases. This study discovered a new method for predicting tumor correlations between BPS interactive genes. According to analyses conducted by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes, interactive genes were primarily found in gastric cancer. Based on gene-targeted prediction and molecular docking, BPS appears to exert potential gastric cancer-causing effects through estrogen receptor 1 (ESR1). In addition, gastric cancer patients' prognosis could be accurately predicted by a bisphenol-based prognostic prediction model. Subsequently, the proliferation and migration abilities of gastric cancer cells were further demonstrated to be significantly enhanced by BPS. Similarly, molecular docking analysis revealed that melatonin is also highly correlated with gastric cancer and BPS. In cell proliferation and migration assays, melatonin and BPS exposure inhibited the invasion abilities of gastric cancer cells compared to BPS-exposure. Our research provided a new direction for the exploration the correlation between cancer and environmental toxicity.http://www.sciencedirect.com/science/article/pii/S0147651323005584ESR1Gastric cancerBisphenol SMelatoninMolecular docking |
| spellingShingle | Yi Wang Jintian Song Yangming Li Chen Lin Yan Chen Xu Zhang Hui Yu Melatonin inhibited the progression of gastric cancer induced by Bisphenol S via regulating the estrogen receptor 1 Ecotoxicology and Environmental Safety ESR1 Gastric cancer Bisphenol S Melatonin Molecular docking |
| title | Melatonin inhibited the progression of gastric cancer induced by Bisphenol S via regulating the estrogen receptor 1 |
| title_full | Melatonin inhibited the progression of gastric cancer induced by Bisphenol S via regulating the estrogen receptor 1 |
| title_fullStr | Melatonin inhibited the progression of gastric cancer induced by Bisphenol S via regulating the estrogen receptor 1 |
| title_full_unstemmed | Melatonin inhibited the progression of gastric cancer induced by Bisphenol S via regulating the estrogen receptor 1 |
| title_short | Melatonin inhibited the progression of gastric cancer induced by Bisphenol S via regulating the estrogen receptor 1 |
| title_sort | melatonin inhibited the progression of gastric cancer induced by bisphenol s via regulating the estrogen receptor 1 |
| topic | ESR1 Gastric cancer Bisphenol S Melatonin Molecular docking |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323005584 |
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