Association between lipid levels and all-cause and cause-specific mortality in critically ill patients
Abstract Extremely low lipid levels are considered a sign of debilitation and illness. The association between lipid levels and the risk of mortality in critically ill patients has not been well investigated. This study was designed to evaluate the association between lipid levels and all-cause and...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-32209-z |
| _version_ | 1797853851034845184 |
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| author | Shan Li Wei Zhang Hongbin Liu |
| author_facet | Shan Li Wei Zhang Hongbin Liu |
| author_sort | Shan Li |
| collection | DOAJ |
| description | Abstract Extremely low lipid levels are considered a sign of debilitation and illness. The association between lipid levels and the risk of mortality in critically ill patients has not been well investigated. This study was designed to evaluate the association between lipid levels and all-cause and cause-specific mortality in critically ill patients using a large collaborative research database known as the eICU database. In total, 27,316 individuals with low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and triglyceride (TG) measurements were analyzed. A J-shaped association was observed between LDL-C, HDL-C, and TC levels and all-cause and noncardiovascular mortality, with low concentrations associated with higher risk. LDL-C, HDL-C and TC levels in the first quintile were associated with higher all-cause and noncardiovascular mortality but not with cardiovascular mortality compared to the reference quintile. There was a marked synergistic effect between low LDL-C combined with low HDL-C on the risk of mortality. Individuals with LDL-C ≤ 96 mg/dL and HDL-C ≤ 27 mg/dL had an increased risk of all-cause mortality (OR 1.52, 95% CI: 1.26–1.82), cardiovascular mortality (OR 1.07, 95% CI: 1.37–1.76) and noncardiovascular mortality (OR 1.82, 95% CI: 1.37–2.43). The results of this observational cohort showed that low LDL-C, HDL-C and TC levels were independently associated with higher all-cause and noncardiovascular mortality in critically ill patients. |
| first_indexed | 2024-04-09T19:56:25Z |
| format | Article |
| id | doaj.art-620c0946aa5f4a559b355a9491a2040c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T19:56:25Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-620c0946aa5f4a559b355a9491a2040c2023-04-03T05:25:05ZengNature PortfolioScientific Reports2045-23222023-03-011311910.1038/s41598-023-32209-zAssociation between lipid levels and all-cause and cause-specific mortality in critically ill patientsShan Li0Wei Zhang1Hongbin Liu2Department of Cardiology, The Second Medical Center, Chinese People Liberation Army General HospitalDepartment of Cardiology, The Second Medical Center, Chinese People Liberation Army General HospitalDepartment of Cardiology, The Second Medical Center, Chinese People Liberation Army General HospitalAbstract Extremely low lipid levels are considered a sign of debilitation and illness. The association between lipid levels and the risk of mortality in critically ill patients has not been well investigated. This study was designed to evaluate the association between lipid levels and all-cause and cause-specific mortality in critically ill patients using a large collaborative research database known as the eICU database. In total, 27,316 individuals with low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and triglyceride (TG) measurements were analyzed. A J-shaped association was observed between LDL-C, HDL-C, and TC levels and all-cause and noncardiovascular mortality, with low concentrations associated with higher risk. LDL-C, HDL-C and TC levels in the first quintile were associated with higher all-cause and noncardiovascular mortality but not with cardiovascular mortality compared to the reference quintile. There was a marked synergistic effect between low LDL-C combined with low HDL-C on the risk of mortality. Individuals with LDL-C ≤ 96 mg/dL and HDL-C ≤ 27 mg/dL had an increased risk of all-cause mortality (OR 1.52, 95% CI: 1.26–1.82), cardiovascular mortality (OR 1.07, 95% CI: 1.37–1.76) and noncardiovascular mortality (OR 1.82, 95% CI: 1.37–2.43). The results of this observational cohort showed that low LDL-C, HDL-C and TC levels were independently associated with higher all-cause and noncardiovascular mortality in critically ill patients.https://doi.org/10.1038/s41598-023-32209-z |
| spellingShingle | Shan Li Wei Zhang Hongbin Liu Association between lipid levels and all-cause and cause-specific mortality in critically ill patients Scientific Reports |
| title | Association between lipid levels and all-cause and cause-specific mortality in critically ill patients |
| title_full | Association between lipid levels and all-cause and cause-specific mortality in critically ill patients |
| title_fullStr | Association between lipid levels and all-cause and cause-specific mortality in critically ill patients |
| title_full_unstemmed | Association between lipid levels and all-cause and cause-specific mortality in critically ill patients |
| title_short | Association between lipid levels and all-cause and cause-specific mortality in critically ill patients |
| title_sort | association between lipid levels and all cause and cause specific mortality in critically ill patients |
| url | https://doi.org/10.1038/s41598-023-32209-z |
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