Association between atherosclerosis and primary Sjogren's syndrome: A cross‐sectional study
Abstract Background and Aims Atherosclerosis (AS) risk increases in patients with systemic autoimmune diseases. The association and mechanism between primary Sjogren's syndrome (pSS) and AS haven't been explained for now. We did this cross‐sectional study to clarify the prevalence and risk...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-10-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.1638 |
| _version_ | 1797310522008272896 |
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| author | Shuang Liu Xingjun Li Qian Yang Nan Wang Jian Xu Luqiong Li Yulong Guo |
| author_facet | Shuang Liu Xingjun Li Qian Yang Nan Wang Jian Xu Luqiong Li Yulong Guo |
| author_sort | Shuang Liu |
| collection | DOAJ |
| description | Abstract Background and Aims Atherosclerosis (AS) risk increases in patients with systemic autoimmune diseases. The association and mechanism between primary Sjogren's syndrome (pSS) and AS haven't been explained for now. We did this cross‐sectional study to clarify the prevalence and risk factors of AS in patients with pSS, and to further explore how immune cells and inflammatory cytokines work in the process. Methods Patients with pSS were enrolled. General information, AS events, immune cells, inflammatory cytokines, and related clinical data were recorded. Prevalence of AS events was calculated. Correlation analysis between immune factors and AS quantitative parameters were conducted by SPSS v20.0. Results A total of 155 pSS patients were included with a median Framingham 10‐year risk of 7%. Sixty‐four AS events were recorded, with a prevalence of 41.3%. Carotid intima‐media thickness was positively correlated to immunoglobulin (Ig) A (r = 0.245, p = 0.030) and negatively correlated to IgM (r = −0.227, p = 0.045). Left ankle‐brachial pulse wave velocity (baPWV) was positively correlated to the course of disease (r = 0.352, p = 0.004), B cells (r = 0.410, p = 0.001), and T helper (Th) cells (r = 0.284, p = 0.029), while negatively correlated to IgM (r = −0.257, p = 0.042). Right baPWV was positively correlated to the course of pSS (r = 0.319, p = 0.010), B cells (r = 0.453, p < 0.001), Th cells (r = 0.302, p = 0.020), and C‐reactive protein (CRP) (r = 0.286, p = 0.042). Use of hydroxychloroquine, cyclophosphamide, and glucocorticoids had no impact on AS events. Conclusion The prevalence of AS in patients with pSS is reported to be 41.3%. Several risk factors have been associated with AS in these patients, including the duration of the disease, levels of Th cells, B lymphocytes, and CRP. Interestingly, IgM appears to have a protective effect against AS. It is worth noting that traditional therapy for pSS does not seem to have any effect in preventing AS events. |
| first_indexed | 2024-03-08T01:45:12Z |
| format | Article |
| id | doaj.art-620e6545ebe84191a290a0c082af1b0a |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-08T01:45:12Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
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| series | Health Science Reports |
| spelling | doaj.art-620e6545ebe84191a290a0c082af1b0a2024-02-14T13:06:23ZengWileyHealth Science Reports2398-88352023-10-01610n/an/a10.1002/hsr2.1638Association between atherosclerosis and primary Sjogren's syndrome: A cross‐sectional studyShuang Liu0Xingjun Li1Qian Yang2Nan Wang3Jian Xu4Luqiong Li5Yulong Guo6Department of Rheumatology and Immunology First Affiliated Hospital of Kunming Medical University Kunming ChinaDepartment of Rheumatology and Immunology First Affiliated Hospital of Kunming Medical University Kunming ChinaDepartment of Cardiology Fuwai Yunnan Cardiovascular Hospital Kunming ChinaDepartment of Rheumatology and Immunology First Affiliated Hospital of Kunming Medical University Kunming ChinaDepartment of Rheumatology and Immunology First Affiliated Hospital of Kunming Medical University Kunming ChinaDepartment of Rheumatology and Immunology First Affiliated Hospital of Kunming Medical University Kunming ChinaDepartment of Cardiology Fuwai Yunnan Cardiovascular Hospital Kunming ChinaAbstract Background and Aims Atherosclerosis (AS) risk increases in patients with systemic autoimmune diseases. The association and mechanism between primary Sjogren's syndrome (pSS) and AS haven't been explained for now. We did this cross‐sectional study to clarify the prevalence and risk factors of AS in patients with pSS, and to further explore how immune cells and inflammatory cytokines work in the process. Methods Patients with pSS were enrolled. General information, AS events, immune cells, inflammatory cytokines, and related clinical data were recorded. Prevalence of AS events was calculated. Correlation analysis between immune factors and AS quantitative parameters were conducted by SPSS v20.0. Results A total of 155 pSS patients were included with a median Framingham 10‐year risk of 7%. Sixty‐four AS events were recorded, with a prevalence of 41.3%. Carotid intima‐media thickness was positively correlated to immunoglobulin (Ig) A (r = 0.245, p = 0.030) and negatively correlated to IgM (r = −0.227, p = 0.045). Left ankle‐brachial pulse wave velocity (baPWV) was positively correlated to the course of disease (r = 0.352, p = 0.004), B cells (r = 0.410, p = 0.001), and T helper (Th) cells (r = 0.284, p = 0.029), while negatively correlated to IgM (r = −0.257, p = 0.042). Right baPWV was positively correlated to the course of pSS (r = 0.319, p = 0.010), B cells (r = 0.453, p < 0.001), Th cells (r = 0.302, p = 0.020), and C‐reactive protein (CRP) (r = 0.286, p = 0.042). Use of hydroxychloroquine, cyclophosphamide, and glucocorticoids had no impact on AS events. Conclusion The prevalence of AS in patients with pSS is reported to be 41.3%. Several risk factors have been associated with AS in these patients, including the duration of the disease, levels of Th cells, B lymphocytes, and CRP. Interestingly, IgM appears to have a protective effect against AS. It is worth noting that traditional therapy for pSS does not seem to have any effect in preventing AS events.https://doi.org/10.1002/hsr2.1638atherosclerosisinflammationprimary Sjogren's syndrome |
| spellingShingle | Shuang Liu Xingjun Li Qian Yang Nan Wang Jian Xu Luqiong Li Yulong Guo Association between atherosclerosis and primary Sjogren's syndrome: A cross‐sectional study Health Science Reports atherosclerosis inflammation primary Sjogren's syndrome |
| title | Association between atherosclerosis and primary Sjogren's syndrome: A cross‐sectional study |
| title_full | Association between atherosclerosis and primary Sjogren's syndrome: A cross‐sectional study |
| title_fullStr | Association between atherosclerosis and primary Sjogren's syndrome: A cross‐sectional study |
| title_full_unstemmed | Association between atherosclerosis and primary Sjogren's syndrome: A cross‐sectional study |
| title_short | Association between atherosclerosis and primary Sjogren's syndrome: A cross‐sectional study |
| title_sort | association between atherosclerosis and primary sjogren s syndrome a cross sectional study |
| topic | atherosclerosis inflammation primary Sjogren's syndrome |
| url | https://doi.org/10.1002/hsr2.1638 |
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