Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury
By 2050, at least 700 million people will require hearing therapy while 2.5 billion are projected to suffer from hearing loss. Sensorineural hearing loss (SNHL) arises from the inability of the inner ear to convert fluid waves into neural electric signals because of injury to cochlear hair cells tha...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/8/7345 |
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| author | Nicholas B. Gill Presley D. Dowker-Key Katelin Hubbard Brynn H. Voy Jay Whelan Mark Hedrick Ahmed Bettaieb |
| author_facet | Nicholas B. Gill Presley D. Dowker-Key Katelin Hubbard Brynn H. Voy Jay Whelan Mark Hedrick Ahmed Bettaieb |
| author_sort | Nicholas B. Gill |
| collection | DOAJ |
| description | By 2050, at least 700 million people will require hearing therapy while 2.5 billion are projected to suffer from hearing loss. Sensorineural hearing loss (SNHL) arises from the inability of the inner ear to convert fluid waves into neural electric signals because of injury to cochlear hair cells that has resulted in their death. In addition, systemic chronic inflammation implicated in other pathologies may exacerbate cell death leading to SNHL. Phytochemicals have emerged as a possible solution because of the growing evidence of their anti-inflammatory, antioxidant, and anti-apoptotic properties. Ginseng and its bioactive molecules, ginsenosides, exhibit effects that suppress pro-inflammatory signaling and protect against apoptosis. In the current study, we investigated the effects of ginsenoside Rc (G-Rc) on UB/OC-2 primary murine sensory hair cell survival in response to palmitate-induced injury. G-Rc promoted UB/OC-2 cell survival and cell cycle progression. Additionally, G-Rc enhanced the differentiation of UB/OC-2 cells into functional sensory hair cells and alleviated palmitate-induced inflammation, endoplasmic reticulum stress, and apoptosis. The current study offers novel insights into the effects of G-Rc as a potential adjuvant for SNHL and warrants further studies elucidating the molecular mechanisms. |
| first_indexed | 2024-03-11T04:56:04Z |
| format | Article |
| id | doaj.art-6211888316814892bd6fa36ec0770017 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:56:04Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6211888316814892bd6fa36ec07700172023-11-17T19:39:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248734510.3390/ijms24087345Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell InjuryNicholas B. Gill0Presley D. Dowker-Key1Katelin Hubbard2Brynn H. Voy3Jay Whelan4Mark Hedrick5Ahmed Bettaieb6Department of Nutrition, University of Tennessee Knoxville, Knoxville, TN 37996-1920, USADepartment of Nutrition, University of Tennessee Knoxville, Knoxville, TN 37996-1920, USADepartment of Nutrition, University of Tennessee Knoxville, Knoxville, TN 37996-1920, USADepartment of Animal Science, University of Tennessee Institute of Agriculture, Knoxville, TN 37996-0840, USADepartment of Nutrition, University of Tennessee Knoxville, Knoxville, TN 37996-1920, USADepartment of Audiology and Speech Pathology, The University of Tennessee Health Science Center, Knoxville, TN 37996-0240, USADepartment of Nutrition, University of Tennessee Knoxville, Knoxville, TN 37996-1920, USABy 2050, at least 700 million people will require hearing therapy while 2.5 billion are projected to suffer from hearing loss. Sensorineural hearing loss (SNHL) arises from the inability of the inner ear to convert fluid waves into neural electric signals because of injury to cochlear hair cells that has resulted in their death. In addition, systemic chronic inflammation implicated in other pathologies may exacerbate cell death leading to SNHL. Phytochemicals have emerged as a possible solution because of the growing evidence of their anti-inflammatory, antioxidant, and anti-apoptotic properties. Ginseng and its bioactive molecules, ginsenosides, exhibit effects that suppress pro-inflammatory signaling and protect against apoptosis. In the current study, we investigated the effects of ginsenoside Rc (G-Rc) on UB/OC-2 primary murine sensory hair cell survival in response to palmitate-induced injury. G-Rc promoted UB/OC-2 cell survival and cell cycle progression. Additionally, G-Rc enhanced the differentiation of UB/OC-2 cells into functional sensory hair cells and alleviated palmitate-induced inflammation, endoplasmic reticulum stress, and apoptosis. The current study offers novel insights into the effects of G-Rc as a potential adjuvant for SNHL and warrants further studies elucidating the molecular mechanisms.https://www.mdpi.com/1422-0067/24/8/7345cochlear hair cellsginsenginflammationoxidative stressER stressapoptosis |
| spellingShingle | Nicholas B. Gill Presley D. Dowker-Key Katelin Hubbard Brynn H. Voy Jay Whelan Mark Hedrick Ahmed Bettaieb Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury International Journal of Molecular Sciences cochlear hair cells ginseng inflammation oxidative stress ER stress apoptosis |
| title | Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury |
| title_full | Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury |
| title_fullStr | Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury |
| title_full_unstemmed | Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury |
| title_short | Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury |
| title_sort | ginsenoside rc from panax ginseng ameliorates palmitate induced ub oc 2 cochlear cell injury |
| topic | cochlear hair cells ginseng inflammation oxidative stress ER stress apoptosis |
| url | https://www.mdpi.com/1422-0067/24/8/7345 |
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