Genetically Predicted Circulating Omega-3 Fatty Acids Levels Are Causally Associated With Increased Risk for Systemic Lupus Erythematosus
BackgroundAccumulating evidence has demonstrated the associations of omega-3 or omega-6 polyunsaturated fatty acids (PUFAs) with the disease activity and inflammatory mediators of systemic lupus erythematosus (SLE), but the evidence of causal links of omega-3 or omega-6 PUFAs on the risk for SLE rem...
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.783338/full |
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| author | Peng Wang Peng Wang Kun Xiang Kun Xiang Yuan-Yuan Xu Yi-Sheng He Yi-Sheng He Yu-Qian Hu Yu-Qian Hu Jing Ni Jing Ni Hai-Feng Pan Hai-Feng Pan |
| author_facet | Peng Wang Peng Wang Kun Xiang Kun Xiang Yuan-Yuan Xu Yi-Sheng He Yi-Sheng He Yu-Qian Hu Yu-Qian Hu Jing Ni Jing Ni Hai-Feng Pan Hai-Feng Pan |
| author_sort | Peng Wang |
| collection | DOAJ |
| description | BackgroundAccumulating evidence has demonstrated the associations of omega-3 or omega-6 polyunsaturated fatty acids (PUFAs) with the disease activity and inflammatory mediators of systemic lupus erythematosus (SLE), but the evidence of causal links of omega-3 or omega-6 PUFAs on the risk for SLE remains inconclusive.ObjectivesThis study was conducted to evaluate the causal relationships between omega-3/omega-6 PUFAs and SLE by performing the Mendelian randomization (MR) analysis.MethodsGenome-wide significant single-nucleotide polymorphisms (SNPs) were obtained from genome-wide association studies (GWASs) of circulating omega-3/omega-6 levels (n = up to 13,544) and GWAS meta-analyses of SLE (n = 14,267), respectively. The bidirectional two-sample MR (TSMR) analysis was conducted to infer the causality.ResultsThe inverse-variance weighted (IVW) method revealed that genetically determined per SD increase in omega-3 levels were causally associated with an increased risk for SLE (odds ratios [ORs] = 1.49, 95% CI: 1.07, 2.08, p = 0.021), but no causal effect of omega-6 on the risk SLE was observed (IVW OR = 1.06, 95% CI: 0.72, 1.57, p = 0.759). In addition, there were no significantly causal associations in genetic predisposition to SLE with the changes of omega-3 and omega-6 levels, respectively (IVW beta for omega-3: 0.007, 95% CI: −0.006, 0.022, p = 0.299; IVW beta for omega-6: −0.008, 95% CI: −0.023, 0.006, p = 0.255).ConclusionThe present study revealed the possible causal role of omega-3 on increasing the risk for SLE, it could be the potential implications for dietary recommendations. |
| first_indexed | 2024-12-17T12:12:25Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-12-17T12:12:25Z |
| publishDate | 2022-02-01 |
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| spelling | doaj.art-6213be0aa5a64523af9497a85ea69dc42022-12-21T21:49:21ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-02-01910.3389/fnut.2022.783338783338Genetically Predicted Circulating Omega-3 Fatty Acids Levels Are Causally Associated With Increased Risk for Systemic Lupus ErythematosusPeng Wang0Peng Wang1Kun Xiang2Kun Xiang3Yuan-Yuan Xu4Yi-Sheng He5Yi-Sheng He6Yu-Qian Hu7Yu-Qian Hu8Jing Ni9Jing Ni10Hai-Feng Pan11Hai-Feng Pan12Teaching Center for Preventive Medicine, School of Public Health, Anhui Medical University, Hefei, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, ChinaDepartment of Outpatient Wound Care Center, 901 Hospital of Joint Logistics Support Force of People Liberation Army, Hefei, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, ChinaBackgroundAccumulating evidence has demonstrated the associations of omega-3 or omega-6 polyunsaturated fatty acids (PUFAs) with the disease activity and inflammatory mediators of systemic lupus erythematosus (SLE), but the evidence of causal links of omega-3 or omega-6 PUFAs on the risk for SLE remains inconclusive.ObjectivesThis study was conducted to evaluate the causal relationships between omega-3/omega-6 PUFAs and SLE by performing the Mendelian randomization (MR) analysis.MethodsGenome-wide significant single-nucleotide polymorphisms (SNPs) were obtained from genome-wide association studies (GWASs) of circulating omega-3/omega-6 levels (n = up to 13,544) and GWAS meta-analyses of SLE (n = 14,267), respectively. The bidirectional two-sample MR (TSMR) analysis was conducted to infer the causality.ResultsThe inverse-variance weighted (IVW) method revealed that genetically determined per SD increase in omega-3 levels were causally associated with an increased risk for SLE (odds ratios [ORs] = 1.49, 95% CI: 1.07, 2.08, p = 0.021), but no causal effect of omega-6 on the risk SLE was observed (IVW OR = 1.06, 95% CI: 0.72, 1.57, p = 0.759). In addition, there were no significantly causal associations in genetic predisposition to SLE with the changes of omega-3 and omega-6 levels, respectively (IVW beta for omega-3: 0.007, 95% CI: −0.006, 0.022, p = 0.299; IVW beta for omega-6: −0.008, 95% CI: −0.023, 0.006, p = 0.255).ConclusionThe present study revealed the possible causal role of omega-3 on increasing the risk for SLE, it could be the potential implications for dietary recommendations.https://www.frontiersin.org/articles/10.3389/fnut.2022.783338/fullomega-3 fatty acidsomega-6 fatty acidssystemic lupus erythematosusSLEMendelian randomization |
| spellingShingle | Peng Wang Peng Wang Kun Xiang Kun Xiang Yuan-Yuan Xu Yi-Sheng He Yi-Sheng He Yu-Qian Hu Yu-Qian Hu Jing Ni Jing Ni Hai-Feng Pan Hai-Feng Pan Genetically Predicted Circulating Omega-3 Fatty Acids Levels Are Causally Associated With Increased Risk for Systemic Lupus Erythematosus Frontiers in Nutrition omega-3 fatty acids omega-6 fatty acids systemic lupus erythematosus SLE Mendelian randomization |
| title | Genetically Predicted Circulating Omega-3 Fatty Acids Levels Are Causally Associated With Increased Risk for Systemic Lupus Erythematosus |
| title_full | Genetically Predicted Circulating Omega-3 Fatty Acids Levels Are Causally Associated With Increased Risk for Systemic Lupus Erythematosus |
| title_fullStr | Genetically Predicted Circulating Omega-3 Fatty Acids Levels Are Causally Associated With Increased Risk for Systemic Lupus Erythematosus |
| title_full_unstemmed | Genetically Predicted Circulating Omega-3 Fatty Acids Levels Are Causally Associated With Increased Risk for Systemic Lupus Erythematosus |
| title_short | Genetically Predicted Circulating Omega-3 Fatty Acids Levels Are Causally Associated With Increased Risk for Systemic Lupus Erythematosus |
| title_sort | genetically predicted circulating omega 3 fatty acids levels are causally associated with increased risk for systemic lupus erythematosus |
| topic | omega-3 fatty acids omega-6 fatty acids systemic lupus erythematosus SLE Mendelian randomization |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.783338/full |
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