Protection from the 2009 H1N1 pandemic influenza by an antibody from combinatorial survivor-based libraries.
Influenza viruses elude immune responses and antiviral chemotherapeutics through genetic drift and reassortment. As a result, the development of new strategies that attack a highly conserved viral function to prevent and/or treat influenza infection is being pursued. Such novel broadly acting antivi...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2010-07-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC2900296?pdf=render |
| _version_ | 1818956290568749056 |
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| author | Arun K Kashyap John Steel Adam Rubrum Angeles Estelles Raffaella Briante Natalia A Ilyushina Li Xu Ryann E Swale Aleksandr M Faynboym Pamela K Foreman Michael Horowitz Lawrence Horowitz Richard Webby Peter Palese Richard A Lerner Ramesh R Bhatt |
| author_facet | Arun K Kashyap John Steel Adam Rubrum Angeles Estelles Raffaella Briante Natalia A Ilyushina Li Xu Ryann E Swale Aleksandr M Faynboym Pamela K Foreman Michael Horowitz Lawrence Horowitz Richard Webby Peter Palese Richard A Lerner Ramesh R Bhatt |
| author_sort | Arun K Kashyap |
| collection | DOAJ |
| description | Influenza viruses elude immune responses and antiviral chemotherapeutics through genetic drift and reassortment. As a result, the development of new strategies that attack a highly conserved viral function to prevent and/or treat influenza infection is being pursued. Such novel broadly acting antiviral therapies would be less susceptible to virus escape and provide a long lasting solution to the evolving virus challenge. Here we report the in vitro and in vivo activity of a human monoclonal antibody (A06) against two isolates of the 2009 H1N1 pandemic influenza virus. This antibody, which was obtained from a combinatorial library derived from a survivor of highly pathogenic H5N1 infection, neutralizes H5N1, seasonal H1N1 and 2009 "Swine" H1N1 pandemic influenza in vitro with similar potency and is capable of preventing and treating 2009 H1N1 influenza infection in murine models of disease. These results demonstrate broad activity of the A06 antibody and its utility as an anti-influenza treatment option, even against newly evolved influenza strains to which there is limited immunity in the general population. |
| first_indexed | 2024-12-20T10:51:36Z |
| format | Article |
| id | doaj.art-6215bc65a50e44a2b76bc04a259a4c3f |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-12-20T10:51:36Z |
| publishDate | 2010-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-6215bc65a50e44a2b76bc04a259a4c3f2022-12-21T19:43:14ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742010-07-0167e100099010.1371/journal.ppat.1000990Protection from the 2009 H1N1 pandemic influenza by an antibody from combinatorial survivor-based libraries.Arun K KashyapJohn SteelAdam RubrumAngeles EstellesRaffaella BrianteNatalia A IlyushinaLi XuRyann E SwaleAleksandr M FaynboymPamela K ForemanMichael HorowitzLawrence HorowitzRichard WebbyPeter PaleseRichard A LernerRamesh R BhattInfluenza viruses elude immune responses and antiviral chemotherapeutics through genetic drift and reassortment. As a result, the development of new strategies that attack a highly conserved viral function to prevent and/or treat influenza infection is being pursued. Such novel broadly acting antiviral therapies would be less susceptible to virus escape and provide a long lasting solution to the evolving virus challenge. Here we report the in vitro and in vivo activity of a human monoclonal antibody (A06) against two isolates of the 2009 H1N1 pandemic influenza virus. This antibody, which was obtained from a combinatorial library derived from a survivor of highly pathogenic H5N1 infection, neutralizes H5N1, seasonal H1N1 and 2009 "Swine" H1N1 pandemic influenza in vitro with similar potency and is capable of preventing and treating 2009 H1N1 influenza infection in murine models of disease. These results demonstrate broad activity of the A06 antibody and its utility as an anti-influenza treatment option, even against newly evolved influenza strains to which there is limited immunity in the general population.http://europepmc.org/articles/PMC2900296?pdf=render |
| spellingShingle | Arun K Kashyap John Steel Adam Rubrum Angeles Estelles Raffaella Briante Natalia A Ilyushina Li Xu Ryann E Swale Aleksandr M Faynboym Pamela K Foreman Michael Horowitz Lawrence Horowitz Richard Webby Peter Palese Richard A Lerner Ramesh R Bhatt Protection from the 2009 H1N1 pandemic influenza by an antibody from combinatorial survivor-based libraries. PLoS Pathogens |
| title | Protection from the 2009 H1N1 pandemic influenza by an antibody from combinatorial survivor-based libraries. |
| title_full | Protection from the 2009 H1N1 pandemic influenza by an antibody from combinatorial survivor-based libraries. |
| title_fullStr | Protection from the 2009 H1N1 pandemic influenza by an antibody from combinatorial survivor-based libraries. |
| title_full_unstemmed | Protection from the 2009 H1N1 pandemic influenza by an antibody from combinatorial survivor-based libraries. |
| title_short | Protection from the 2009 H1N1 pandemic influenza by an antibody from combinatorial survivor-based libraries. |
| title_sort | protection from the 2009 h1n1 pandemic influenza by an antibody from combinatorial survivor based libraries |
| url | http://europepmc.org/articles/PMC2900296?pdf=render |
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