Primary PEComa of the bladder treated with primary excision and adjuvant interferon-alpha immunotherapy: a case report
<p>Abstract</p> <p>Background</p> <p>Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal neoplasms of uncertain malignant potential, which have in common the co-expression of muscle and melanocytic immunohistochemical markers.</p> <p>Case pre...
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| Format: | Article |
| Language: | English |
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BMC
2006-08-01
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| Series: | BMC Urology |
| Online Access: | http://www.biomedcentral.com/1471-2490/6/20 |
| _version_ | 1818542400102989824 |
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| author | Wehrli Bret M Bella Anthony J Parfitt Jeremy R Izawa Jonathan I |
| author_facet | Wehrli Bret M Bella Anthony J Parfitt Jeremy R Izawa Jonathan I |
| author_sort | Wehrli Bret M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal neoplasms of uncertain malignant potential, which have in common the co-expression of muscle and melanocytic immunohistochemical markers.</p> <p>Case presentation</p> <p>A 48-year-old man presented with dysuria, passage of urinary sediment and lower abdominal discomfort. A three centimeter mass was identified by cystoscopy in the posterior midline of the bladder. Computerized tomography suggested an enterovesical fistula. The patient underwent laparotomy, partial cystectomy and partial small bowel resection. Pathological examination revealed PEComa of the bladder. The patient underwent adjuvant interferon-α immunotherapy. Subsequent follow-up procedures, including cystoscopy and imaging, have not revealed evidence of recurrence. The patient is clinically free of disease 48 months after surgery.</p> <p>Conclusion</p> <p>This case represents the second documented PEComa of bladder and demonstrates that adjuvant therapies, including anti-angiogenic and immunotherapy, may be considered for patients with locally advanced or metastatic genitourinary PEComa.</p> |
| first_indexed | 2024-12-11T22:21:34Z |
| format | Article |
| id | doaj.art-6215cf6eecad4cf1996d927878c03078 |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-12-11T22:21:34Z |
| publishDate | 2006-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-6215cf6eecad4cf1996d927878c030782022-12-22T00:48:26ZengBMCBMC Urology1471-24902006-08-01612010.1186/1471-2490-6-20Primary PEComa of the bladder treated with primary excision and adjuvant interferon-alpha immunotherapy: a case reportWehrli Bret MBella Anthony JParfitt Jeremy RIzawa Jonathan I<p>Abstract</p> <p>Background</p> <p>Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal neoplasms of uncertain malignant potential, which have in common the co-expression of muscle and melanocytic immunohistochemical markers.</p> <p>Case presentation</p> <p>A 48-year-old man presented with dysuria, passage of urinary sediment and lower abdominal discomfort. A three centimeter mass was identified by cystoscopy in the posterior midline of the bladder. Computerized tomography suggested an enterovesical fistula. The patient underwent laparotomy, partial cystectomy and partial small bowel resection. Pathological examination revealed PEComa of the bladder. The patient underwent adjuvant interferon-α immunotherapy. Subsequent follow-up procedures, including cystoscopy and imaging, have not revealed evidence of recurrence. The patient is clinically free of disease 48 months after surgery.</p> <p>Conclusion</p> <p>This case represents the second documented PEComa of bladder and demonstrates that adjuvant therapies, including anti-angiogenic and immunotherapy, may be considered for patients with locally advanced or metastatic genitourinary PEComa.</p>http://www.biomedcentral.com/1471-2490/6/20 |
| spellingShingle | Wehrli Bret M Bella Anthony J Parfitt Jeremy R Izawa Jonathan I Primary PEComa of the bladder treated with primary excision and adjuvant interferon-alpha immunotherapy: a case report BMC Urology |
| title | Primary PEComa of the bladder treated with primary excision and adjuvant interferon-alpha immunotherapy: a case report |
| title_full | Primary PEComa of the bladder treated with primary excision and adjuvant interferon-alpha immunotherapy: a case report |
| title_fullStr | Primary PEComa of the bladder treated with primary excision and adjuvant interferon-alpha immunotherapy: a case report |
| title_full_unstemmed | Primary PEComa of the bladder treated with primary excision and adjuvant interferon-alpha immunotherapy: a case report |
| title_short | Primary PEComa of the bladder treated with primary excision and adjuvant interferon-alpha immunotherapy: a case report |
| title_sort | primary pecoma of the bladder treated with primary excision and adjuvant interferon alpha immunotherapy a case report |
| url | http://www.biomedcentral.com/1471-2490/6/20 |
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