Combined Water Extracts from Oxidation-Treated Leaves and Branches of <i>Hovenia dulcis</i> Has Anti-Hangover and Liver Protective Effects in Binge Alcohol Intake of Male Mice
<i>Hovenia dulcis</i>, known as the oriental raisin tree, is used for food supplements and traditional medicine for the liver after alcohol-related symptoms. However, little information exists about the use of its leaves and branches. In this study, we established a method to use the lea...
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MDPI AG
2021-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/12/4404 |
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| author | Jihyun Je Miyoung Song Ji Hyeong Baek Jae Soon Kang Hye Jin Chung Kwonsu Lee Sang Won Park Hyun Joon Kim |
| author_facet | Jihyun Je Miyoung Song Ji Hyeong Baek Jae Soon Kang Hye Jin Chung Kwonsu Lee Sang Won Park Hyun Joon Kim |
| author_sort | Jihyun Je |
| collection | DOAJ |
| description | <i>Hovenia dulcis</i>, known as the oriental raisin tree, is used for food supplements and traditional medicine for the liver after alcohol-related symptoms. However, little information exists about the use of its leaves and branches. In this study, we established a method to use the leaves and branches to develop anti-hangover treatment and elucidated the underlying mechanisms. Oxidation-treated leaves (OL) exhibited high antioxidant content comparable to that of the peduncles and showed an anti-hangover effect in male mice. The branch extract (BE) was enriched in the flavonoid catechin, approximately five times more than OL extract. The mixture of OL and BE (OLB) was formulated in a 2:1 ratio with frozen-dried extract weight and was tested for anti-hangover effects and protective properties against binge alcohol-induced liver injury. OLB showed better anti-hangover effect than OL. In addition to this anti-hangover effect, OLB protected the liver from oxidative/nitrosative damage induced by binge alcohol intake. |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T03:23:23Z |
| publishDate | 2021-12-01 |
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| series | Nutrients |
| spelling | doaj.art-621678b2cf9d433882adcfe5a5f685d42023-11-23T09:57:15ZengMDPI AGNutrients2072-66432021-12-011312440410.3390/nu13124404Combined Water Extracts from Oxidation-Treated Leaves and Branches of <i>Hovenia dulcis</i> Has Anti-Hangover and Liver Protective Effects in Binge Alcohol Intake of Male MiceJihyun Je0Miyoung Song1Ji Hyeong Baek2Jae Soon Kang3Hye Jin Chung4Kwonsu Lee5Sang Won Park6Hyun Joon Kim7Department of Pharmacology, Institute of Health Sciences, Anti-Aging Bio Cell Factory Regional Leading Research Center, Gyeongsang National University Medical School, 15 Jinju-daero 816 Beongil, Jinju 52727, Gyeongnam, KoreaDepartment of Anatomy and Convergence Medical Sciences, Institute of Health Sciences, Anti-Aging Bio Cell Factory Regional Leading Research Center, Gyeongsang National University Medical School, 15 Jinju-daero 816 Beongil, Jinju 52727, Gyeongnam, KoreaDepartment of Anatomy and Convergence Medical Sciences, Institute of Health Sciences, Anti-Aging Bio Cell Factory Regional Leading Research Center, Gyeongsang National University Medical School, 15 Jinju-daero 816 Beongil, Jinju 52727, Gyeongnam, KoreaDepartment of Anatomy and Convergence Medical Sciences, Institute of Health Sciences, Anti-Aging Bio Cell Factory Regional Leading Research Center, Gyeongsang National University Medical School, 15 Jinju-daero 816 Beongil, Jinju 52727, Gyeongnam, KoreaCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, Gyeongnam, KoreaMalgeunsan Agricultural Union Corp., 991 Wolasan-ro, Munsan-eup, Jinju 52839, Gyeongnam, KoreaDepartment of Pharmacology, Institute of Health Sciences, Anti-Aging Bio Cell Factory Regional Leading Research Center, Gyeongsang National University Medical School, 15 Jinju-daero 816 Beongil, Jinju 52727, Gyeongnam, KoreaDepartment of Anatomy and Convergence Medical Sciences, Institute of Health Sciences, Anti-Aging Bio Cell Factory Regional Leading Research Center, Gyeongsang National University Medical School, 15 Jinju-daero 816 Beongil, Jinju 52727, Gyeongnam, Korea<i>Hovenia dulcis</i>, known as the oriental raisin tree, is used for food supplements and traditional medicine for the liver after alcohol-related symptoms. However, little information exists about the use of its leaves and branches. In this study, we established a method to use the leaves and branches to develop anti-hangover treatment and elucidated the underlying mechanisms. Oxidation-treated leaves (OL) exhibited high antioxidant content comparable to that of the peduncles and showed an anti-hangover effect in male mice. The branch extract (BE) was enriched in the flavonoid catechin, approximately five times more than OL extract. The mixture of OL and BE (OLB) was formulated in a 2:1 ratio with frozen-dried extract weight and was tested for anti-hangover effects and protective properties against binge alcohol-induced liver injury. OLB showed better anti-hangover effect than OL. In addition to this anti-hangover effect, OLB protected the liver from oxidative/nitrosative damage induced by binge alcohol intake.https://www.mdpi.com/2072-6643/13/12/4404alcohol-induced liver injuryflavonoid catechinanti-hangoveroxidative/nitrosative<i>Hovenia dulcis</i> |
| spellingShingle | Jihyun Je Miyoung Song Ji Hyeong Baek Jae Soon Kang Hye Jin Chung Kwonsu Lee Sang Won Park Hyun Joon Kim Combined Water Extracts from Oxidation-Treated Leaves and Branches of <i>Hovenia dulcis</i> Has Anti-Hangover and Liver Protective Effects in Binge Alcohol Intake of Male Mice Nutrients alcohol-induced liver injury flavonoid catechin anti-hangover oxidative/nitrosative <i>Hovenia dulcis</i> |
| title | Combined Water Extracts from Oxidation-Treated Leaves and Branches of <i>Hovenia dulcis</i> Has Anti-Hangover and Liver Protective Effects in Binge Alcohol Intake of Male Mice |
| title_full | Combined Water Extracts from Oxidation-Treated Leaves and Branches of <i>Hovenia dulcis</i> Has Anti-Hangover and Liver Protective Effects in Binge Alcohol Intake of Male Mice |
| title_fullStr | Combined Water Extracts from Oxidation-Treated Leaves and Branches of <i>Hovenia dulcis</i> Has Anti-Hangover and Liver Protective Effects in Binge Alcohol Intake of Male Mice |
| title_full_unstemmed | Combined Water Extracts from Oxidation-Treated Leaves and Branches of <i>Hovenia dulcis</i> Has Anti-Hangover and Liver Protective Effects in Binge Alcohol Intake of Male Mice |
| title_short | Combined Water Extracts from Oxidation-Treated Leaves and Branches of <i>Hovenia dulcis</i> Has Anti-Hangover and Liver Protective Effects in Binge Alcohol Intake of Male Mice |
| title_sort | combined water extracts from oxidation treated leaves and branches of i hovenia dulcis i has anti hangover and liver protective effects in binge alcohol intake of male mice |
| topic | alcohol-induced liver injury flavonoid catechin anti-hangover oxidative/nitrosative <i>Hovenia dulcis</i> |
| url | https://www.mdpi.com/2072-6643/13/12/4404 |
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