Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia
Objective:Chromosomal abnormalities are one of the most important prognostic factors in acute myeloid leukemia (AML). However, not all patients may have such informative chromosomal abnormalities. Although there are many studies on the prognostic value of immunophenotyping in AML, it is still not us...
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| Format: | Article |
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Galenos Publishing House
2022-08-01
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| Series: | Bezmiâlem Science |
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http://bezmialemscience.org/archives/archive-detail/article-preview/prognostic-significance-of-flow-cytometric-mmunoph/52680
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| author | Sinan DEMİRCİOĞLU Ömer EKİNCİ Ali DOĞAN Turgay ULAŞ |
| author_facet | Sinan DEMİRCİOĞLU Ömer EKİNCİ Ali DOĞAN Turgay ULAŞ |
| author_sort | Sinan DEMİRCİOĞLU |
| collection | DOAJ |
| description | Objective:Chromosomal abnormalities are one of the most important prognostic factors in acute myeloid leukemia (AML). However, not all patients may have such informative chromosomal abnormalities. Although there are many studies on the prognostic value of immunophenotyping in AML, it is still not used as a prognostic marker. In this study, we aimed to investigate the effects of CD13, CD33, CD34, CD117, MPO and HLADR expressions on prognosis of non-acute promyelocytic leukemia AML.Methods:One hundred thirteen patients diagnosed as having non- acute promyelocytic leukemia AML and followed up between 2010 and 2018 were included in this study. The associations of CD13, CD33, CD34, CD117, MPO and HLA DR expressions with chemotherapy response, progression free survival (PFS) and overall survival (OS) were statistically analyzed.Results:It was seen that response to chemotherapy was achieved in 67.3% of the patients. Median PFS duration was 9 months and median OS duration was found as 13 months. Of the immunophenotypic characteristics, only MPO expression was determined to be an independent risk factor for PFS and OS.Conclusion:Immunophenotypic features may be helpful in the diagnosis of AML as well as give an idea about prognosis. In this study, MPO expression was shown to be an independent risk factor for PFS and OS in our own patient population. |
| first_indexed | 2024-04-10T13:03:43Z |
| format | Article |
| id | doaj.art-6216e4967c524ad7bc6db8917f8320da |
| institution | Directory Open Access Journal |
| issn | 2148-2373 |
| language | English |
| last_indexed | 2024-04-10T13:03:43Z |
| publishDate | 2022-08-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Bezmiâlem Science |
| spelling | doaj.art-6216e4967c524ad7bc6db8917f8320da2023-02-15T16:13:03ZengGalenos Publishing HouseBezmiâlem Science2148-23732022-08-0110440240810.14235/bas.galenos.2021.587513049054Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid LeukemiaSinan DEMİRCİOĞLU0Ömer EKİNCİ1Ali DOĞAN2Turgay ULAŞ3 Necmettin Erbakan University Meram Faculty of Medicine, Department of Hematology, Konya, Turkey Fırat University Faculty of Medicine, Department of Hematology, Elazığ, Turkey Van Yüzüncü Yıl University Faculty of Medicine, Department of Hematology, Van, Turkey Yakın Doğu University Faculty of Medicine, Department of Hematology, Lefkoşa, Northern Cyprus TR Objective:Chromosomal abnormalities are one of the most important prognostic factors in acute myeloid leukemia (AML). However, not all patients may have such informative chromosomal abnormalities. Although there are many studies on the prognostic value of immunophenotyping in AML, it is still not used as a prognostic marker. In this study, we aimed to investigate the effects of CD13, CD33, CD34, CD117, MPO and HLADR expressions on prognosis of non-acute promyelocytic leukemia AML.Methods:One hundred thirteen patients diagnosed as having non- acute promyelocytic leukemia AML and followed up between 2010 and 2018 were included in this study. The associations of CD13, CD33, CD34, CD117, MPO and HLA DR expressions with chemotherapy response, progression free survival (PFS) and overall survival (OS) were statistically analyzed.Results:It was seen that response to chemotherapy was achieved in 67.3% of the patients. Median PFS duration was 9 months and median OS duration was found as 13 months. Of the immunophenotypic characteristics, only MPO expression was determined to be an independent risk factor for PFS and OS.Conclusion:Immunophenotypic features may be helpful in the diagnosis of AML as well as give an idea about prognosis. In this study, MPO expression was shown to be an independent risk factor for PFS and OS in our own patient population. http://bezmialemscience.org/archives/archive-detail/article-preview/prognostic-significance-of-flow-cytometric-mmunoph/52680 acute myeloid leukemiaimmunophenotypingprognosissurvival |
| spellingShingle | Sinan DEMİRCİOĞLU Ömer EKİNCİ Ali DOĞAN Turgay ULAŞ Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia Bezmiâlem Science acute myeloid leukemia immunophenotyping prognosis survival |
| title | Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia |
| title_full | Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia |
| title_fullStr | Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia |
| title_full_unstemmed | Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia |
| title_short | Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia |
| title_sort | prognostic significance of flow cytometric immunophenotyping in patients with acute myeloid leukemia |
| topic | acute myeloid leukemia immunophenotyping prognosis survival |
| url |
http://bezmialemscience.org/archives/archive-detail/article-preview/prognostic-significance-of-flow-cytometric-mmunoph/52680
|
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