Downregulation of hsa_circ_0004543 Activates oxLDL-Induced Vascular Endothelial Cell Proliferation and Angiogenesis
Circular RNAs (circRNAs) are novel non-coding RNAs, which show abnormal expression in several diseases, such as atherosclerosis (AS). The purpose of the present study was to reveal the association between hsa_circ_0004543 and AS. In the present study, hsa_circ_0004543 was overexpressed in human umbi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2021.632164/full |
| _version_ | 1824034122364878848 |
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| author | Lu Han Dandan Li Yanwen Hang Xiaojuan Zong Jiashun Lv Xiaolu Bai Yi Lu Peng Zhang Meiling Zhou Zhaodi Wu Wei Hu |
| author_facet | Lu Han Dandan Li Yanwen Hang Xiaojuan Zong Jiashun Lv Xiaolu Bai Yi Lu Peng Zhang Meiling Zhou Zhaodi Wu Wei Hu |
| author_sort | Lu Han |
| collection | DOAJ |
| description | Circular RNAs (circRNAs) are novel non-coding RNAs, which show abnormal expression in several diseases, such as atherosclerosis (AS). The purpose of the present study was to reveal the association between hsa_circ_0004543 and AS. In the present study, hsa_circ_0004543 was overexpressed in human umbilical vein endothelial cells (HUVECs) induced by oxidized low-density lipoprotein (oxLDL). Inhibition of hsa_circ_0004543 expression facilitated the proliferation, migration, and invasion of HUVECs and significantly reduced their apoptotic rate following treatment with oxLDL. Furthermore, silencing of hsa_circ_0004543 activated the PI3K/AKT/NOS3 pathway in oxLDL-induced HUVECs. Collectively, these results demonstrated that hsa_circ_0004543 may play a vital role in the development of AS and affect the proliferation of HUVECs, providing a potential target for treating endothelial cell damage in AS. |
| first_indexed | 2024-12-22T17:52:55Z |
| format | Article |
| id | doaj.art-621840c8901344f9963f8f26f56e34ea |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-22T17:52:55Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-621840c8901344f9963f8f26f56e34ea2022-12-21T18:18:08ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-03-011210.3389/fgene.2021.632164632164Downregulation of hsa_circ_0004543 Activates oxLDL-Induced Vascular Endothelial Cell Proliferation and AngiogenesisLu HanDandan LiYanwen HangXiaojuan ZongJiashun LvXiaolu BaiYi LuPeng ZhangMeiling ZhouZhaodi WuWei HuCircular RNAs (circRNAs) are novel non-coding RNAs, which show abnormal expression in several diseases, such as atherosclerosis (AS). The purpose of the present study was to reveal the association between hsa_circ_0004543 and AS. In the present study, hsa_circ_0004543 was overexpressed in human umbilical vein endothelial cells (HUVECs) induced by oxidized low-density lipoprotein (oxLDL). Inhibition of hsa_circ_0004543 expression facilitated the proliferation, migration, and invasion of HUVECs and significantly reduced their apoptotic rate following treatment with oxLDL. Furthermore, silencing of hsa_circ_0004543 activated the PI3K/AKT/NOS3 pathway in oxLDL-induced HUVECs. Collectively, these results demonstrated that hsa_circ_0004543 may play a vital role in the development of AS and affect the proliferation of HUVECs, providing a potential target for treating endothelial cell damage in AS.https://www.frontiersin.org/articles/10.3389/fgene.2021.632164/fullhsa_circ_0004543atherosclerosisangiogenesisvascular endothelial cellstreatment |
| spellingShingle | Lu Han Dandan Li Yanwen Hang Xiaojuan Zong Jiashun Lv Xiaolu Bai Yi Lu Peng Zhang Meiling Zhou Zhaodi Wu Wei Hu Downregulation of hsa_circ_0004543 Activates oxLDL-Induced Vascular Endothelial Cell Proliferation and Angiogenesis Frontiers in Genetics hsa_circ_0004543 atherosclerosis angiogenesis vascular endothelial cells treatment |
| title | Downregulation of hsa_circ_0004543 Activates oxLDL-Induced Vascular Endothelial Cell Proliferation and Angiogenesis |
| title_full | Downregulation of hsa_circ_0004543 Activates oxLDL-Induced Vascular Endothelial Cell Proliferation and Angiogenesis |
| title_fullStr | Downregulation of hsa_circ_0004543 Activates oxLDL-Induced Vascular Endothelial Cell Proliferation and Angiogenesis |
| title_full_unstemmed | Downregulation of hsa_circ_0004543 Activates oxLDL-Induced Vascular Endothelial Cell Proliferation and Angiogenesis |
| title_short | Downregulation of hsa_circ_0004543 Activates oxLDL-Induced Vascular Endothelial Cell Proliferation and Angiogenesis |
| title_sort | downregulation of hsa circ 0004543 activates oxldl induced vascular endothelial cell proliferation and angiogenesis |
| topic | hsa_circ_0004543 atherosclerosis angiogenesis vascular endothelial cells treatment |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2021.632164/full |
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