Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives
The last decade has witnessed dramatic growth in the number of reactions catalyzed by gold complexes because of their powerful soft Lewis acid nature. In particular, the gold-catalyzed activation of propargylic compounds has progressively emerged in recent years. Some of these gold-catalyzed reactio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-09-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/16/9/7815/ |
| _version_ | 1828370962176802816 |
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| author | Pedro Almendros José M. Alonso Benito Alcaide |
| author_facet | Pedro Almendros José M. Alonso Benito Alcaide |
| author_sort | Pedro Almendros |
| collection | DOAJ |
| description | The last decade has witnessed dramatic growth in the number of reactions catalyzed by gold complexes because of their powerful soft Lewis acid nature. In particular, the gold-catalyzed activation of propargylic compounds has progressively emerged in recent years. Some of these gold-catalyzed reactions in alkynes have been optimized and show significant utility in organic synthesis. Thus, apart from significant methodology work, in the meantime gold-catalyzed cyclizations in alkynol derivatives have become an efficient tool in total synthesis. However, there is a lack of specific review articles covering the joined importance of both gold salts and alkynol-based compounds for the synthesis of natural products and derivatives. The aim of this Review is to survey the chemistry of alkynol derivatives under gold-catalyzed cyclization conditions and its utility in total synthesis, concentrating on the advances that have been made in the last decade, and in particular in the last quinquennium. |
| first_indexed | 2024-04-14T06:44:45Z |
| format | Article |
| id | doaj.art-621a0a4d24f5415a811813ac8eada6c2 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-14T06:44:45Z |
| publishDate | 2011-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-621a0a4d24f5415a811813ac8eada6c22022-12-22T02:07:12ZengMDPI AGMolecules1420-30492011-09-011697815784310.3390/molecules16097815Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and DerivativesPedro AlmendrosJosé M. AlonsoBenito AlcaideThe last decade has witnessed dramatic growth in the number of reactions catalyzed by gold complexes because of their powerful soft Lewis acid nature. In particular, the gold-catalyzed activation of propargylic compounds has progressively emerged in recent years. Some of these gold-catalyzed reactions in alkynes have been optimized and show significant utility in organic synthesis. Thus, apart from significant methodology work, in the meantime gold-catalyzed cyclizations in alkynol derivatives have become an efficient tool in total synthesis. However, there is a lack of specific review articles covering the joined importance of both gold salts and alkynol-based compounds for the synthesis of natural products and derivatives. The aim of this Review is to survey the chemistry of alkynol derivatives under gold-catalyzed cyclization conditions and its utility in total synthesis, concentrating on the advances that have been made in the last decade, and in particular in the last quinquennium.http://www.mdpi.com/1420-3049/16/9/7815/gold catalysisalkynolstotal synthesisnatural products |
| spellingShingle | Pedro Almendros José M. Alonso Benito Alcaide Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives Molecules gold catalysis alkynols total synthesis natural products |
| title | Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives |
| title_full | Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives |
| title_fullStr | Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives |
| title_full_unstemmed | Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives |
| title_short | Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives |
| title_sort | gold catalyzed cyclizations of alkynol based compounds synthesis of natural products and derivatives |
| topic | gold catalysis alkynols total synthesis natural products |
| url | http://www.mdpi.com/1420-3049/16/9/7815/ |
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