Efficacy of the Combination of Teriparatide and Denosumab in the Treatment of Postmenopausal Osteoporosis: A Meta-Analysis
Aim: Evidence on the efficacy of combination treatment of teriparatide and denosumab for osteoporosis remains controversial. We aim to compare the efficacy between the combination treatment and monotherapy among patients with postmenopausal osteoporosis.Methods and results: We systematically searche...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.888208/full |
| _version_ | 1811256572263792640 |
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| author | Yang Sun Yue Li Jiangbi Li Xiaoping Xie Feng Gu Zhenjiang Sui Ke Zhang Tiecheng Yu |
| author_facet | Yang Sun Yue Li Jiangbi Li Xiaoping Xie Feng Gu Zhenjiang Sui Ke Zhang Tiecheng Yu |
| author_sort | Yang Sun |
| collection | DOAJ |
| description | Aim: Evidence on the efficacy of combination treatment of teriparatide and denosumab for osteoporosis remains controversial. We aim to compare the efficacy between the combination treatment and monotherapy among patients with postmenopausal osteoporosis.Methods and results: We systematically searched PubMed, EMBASE, the Cochrane Library, and Web of Science up to 26 January 2022, for relevant studies. This meta-analysis reviewed all randomized controlled trials (RCTs) that reported on the combination treatment of teriparatide and denosumab in patients with postmenopausal osteoporosis. The articles were examined individually by two reviewers, and the relevant data was extracted. We combined weighted mean difference (WMD) for bone mineral density (BMD) using random- or fixed- effect models and conducted subgroup analyses. Sensitivity analyses were performed, and possible publication bias was also assessed. Overall, combination treatment enhanced the mean percent change of bone mineral density in lumbar spine than monotherapy (WMD = 2.91, 95%CI: 1.983.83; p = 0.00). And, combination treatment has been beneficial for enhancing the mean percent change of BMD in hip (WMD = 3.19, 95%CI: 2.25∼4.13; p = 0.00). There was no significant difference between combination treatment and monotherapy in terms of the adverse events (RR = 0.81, 95%CI: 0.45∼1.45; p = 0.472).Conclusion: The meta-analysis indicates that combination treatment led to greater BMD at the lumbar spine and hip in comparison to monotherapy, without an increased incidence of adverse events.Systematic Review Registration: (https://inplasy.com/), identifier (Inplasy Protocol 2734). |
| first_indexed | 2024-04-12T17:43:31Z |
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| id | doaj.art-621a0f7151ad4e499c6cc6d290e58cf2 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T17:43:31Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-621a0f7151ad4e499c6cc6d290e58cf22022-12-22T03:22:45ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-05-011310.3389/fphar.2022.888208888208Efficacy of the Combination of Teriparatide and Denosumab in the Treatment of Postmenopausal Osteoporosis: A Meta-AnalysisYang Sun0Yue Li1Jiangbi Li2Xiaoping Xie3Feng Gu4Zhenjiang Sui5Ke Zhang6Tiecheng Yu7Department of Orthopedics, The First Hospital of Jilin University, Jilin Changchun, ChinaDepartment of Social Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, ChinaDepartment of Orthopedics, The First Hospital of Jilin University, Jilin Changchun, ChinaDepartment of Orthopedics, The First Hospital of Jilin University, Jilin Changchun, ChinaDepartment of Orthopedics, The First Hospital of Jilin University, Jilin Changchun, ChinaDepartment of Orthopedics, The First Hospital of Jilin University, Jilin Changchun, ChinaDepartment of Orthopedics, The First Hospital of Jilin University, Jilin Changchun, ChinaDepartment of Orthopedics, The First Hospital of Jilin University, Jilin Changchun, ChinaAim: Evidence on the efficacy of combination treatment of teriparatide and denosumab for osteoporosis remains controversial. We aim to compare the efficacy between the combination treatment and monotherapy among patients with postmenopausal osteoporosis.Methods and results: We systematically searched PubMed, EMBASE, the Cochrane Library, and Web of Science up to 26 January 2022, for relevant studies. This meta-analysis reviewed all randomized controlled trials (RCTs) that reported on the combination treatment of teriparatide and denosumab in patients with postmenopausal osteoporosis. The articles were examined individually by two reviewers, and the relevant data was extracted. We combined weighted mean difference (WMD) for bone mineral density (BMD) using random- or fixed- effect models and conducted subgroup analyses. Sensitivity analyses were performed, and possible publication bias was also assessed. Overall, combination treatment enhanced the mean percent change of bone mineral density in lumbar spine than monotherapy (WMD = 2.91, 95%CI: 1.983.83; p = 0.00). And, combination treatment has been beneficial for enhancing the mean percent change of BMD in hip (WMD = 3.19, 95%CI: 2.25∼4.13; p = 0.00). There was no significant difference between combination treatment and monotherapy in terms of the adverse events (RR = 0.81, 95%CI: 0.45∼1.45; p = 0.472).Conclusion: The meta-analysis indicates that combination treatment led to greater BMD at the lumbar spine and hip in comparison to monotherapy, without an increased incidence of adverse events.Systematic Review Registration: (https://inplasy.com/), identifier (Inplasy Protocol 2734).https://www.frontiersin.org/articles/10.3389/fphar.2022.888208/fullpostmenopausal osteoporosiscombination treatmentteriparatidedenosumabmonotherapy |
| spellingShingle | Yang Sun Yue Li Jiangbi Li Xiaoping Xie Feng Gu Zhenjiang Sui Ke Zhang Tiecheng Yu Efficacy of the Combination of Teriparatide and Denosumab in the Treatment of Postmenopausal Osteoporosis: A Meta-Analysis Frontiers in Pharmacology postmenopausal osteoporosis combination treatment teriparatide denosumab monotherapy |
| title | Efficacy of the Combination of Teriparatide and Denosumab in the Treatment of Postmenopausal Osteoporosis: A Meta-Analysis |
| title_full | Efficacy of the Combination of Teriparatide and Denosumab in the Treatment of Postmenopausal Osteoporosis: A Meta-Analysis |
| title_fullStr | Efficacy of the Combination of Teriparatide and Denosumab in the Treatment of Postmenopausal Osteoporosis: A Meta-Analysis |
| title_full_unstemmed | Efficacy of the Combination of Teriparatide and Denosumab in the Treatment of Postmenopausal Osteoporosis: A Meta-Analysis |
| title_short | Efficacy of the Combination of Teriparatide and Denosumab in the Treatment of Postmenopausal Osteoporosis: A Meta-Analysis |
| title_sort | efficacy of the combination of teriparatide and denosumab in the treatment of postmenopausal osteoporosis a meta analysis |
| topic | postmenopausal osteoporosis combination treatment teriparatide denosumab monotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.888208/full |
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