Cholesterol-Based Nanovesicles Enhance the In Vitro Cytotoxicity, Ex Vivo Intestinal Absorption, and In Vivo Bioavailability of Flutamide

Cholesterol-Based Nanovesicles Enhance the In Vitro Cytotoxicity, Ex Vivo Intestinal Absorption, and In Vivo Bioavailability of Flutamide

Critical adverse effects and frequent administration, three times per day, limit the use of flutamide (FLT) as a chemotherapeutic agent in the treatment of prostate cancer. Therefore, our research aimed to develop new cholesterol-based nanovesicles for delivering FLT to malignant cells in an endeavo...

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Bibliographic Details
Main Authors: Mohamed A. Ali, Magdy I. Mohamed, Mohamed A. Megahed, Tamer M. Abdelghany, Khalid M. El-Say
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceutics
Subjects:
Draper–Lin small composite design
ex vivo intestinal permeation
flutamide
in vitro cytotoxicity
optimization
in vivo pharmacokinetics
Online Access:https://www.mdpi.com/1999-4923/13/11/1741

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