Melanogenesis and hypopigmentation: The case of vitiligo
Melanocytes are highly specialized dendritic cells that synthesize and store melanin in subcellular organelles called melanosomes, before transfer to keratinocytes. Melanin is a complex pigment that provides colour and photoprotection to the skin, hair and eyes. The process of synthesis of melanin i...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
|
| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2022;volume=67;issue=5;spage=524;epage=530;aulast=Vinardell |
| _version_ | 1797954994081628160 |
|---|---|
| author | M Pilar Vinardell Adriana Solange Maddaleno Montserrat Mitjans |
| author_facet | M Pilar Vinardell Adriana Solange Maddaleno Montserrat Mitjans |
| author_sort | M Pilar Vinardell |
| collection | DOAJ |
| description | Melanocytes are highly specialized dendritic cells that synthesize and store melanin in subcellular organelles called melanosomes, before transfer to keratinocytes. Melanin is a complex pigment that provides colour and photoprotection to the skin, hair and eyes. The process of synthesis of melanin is called melanogenesis and is regulated by various mechanisms and factors such as genetic, environmental and endocrine factors. The knowledge of the pigmentation process is important to understand hypopigmentation disorders such as vitiligo and also to design adequate treatments. In the present work, we review the signalling pathways involved in vitiligo. Finally, current therapies and treatments including topical, oral and phototherapies are discussed and described, emphasizing future therapies based on different pigmentation mechanisms. |
| first_indexed | 2024-04-10T23:27:21Z |
| format | Article |
| id | doaj.art-621c19c4528d4a649850f92ac9401c39 |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-04-10T23:27:21Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-621c19c4528d4a649850f92ac9401c392023-01-12T11:31:44ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112022-01-0167552453010.4103/ijd.ijd_1067_21Melanogenesis and hypopigmentation: The case of vitiligoM Pilar VinardellAdriana Solange MaddalenoMontserrat MitjansMelanocytes are highly specialized dendritic cells that synthesize and store melanin in subcellular organelles called melanosomes, before transfer to keratinocytes. Melanin is a complex pigment that provides colour and photoprotection to the skin, hair and eyes. The process of synthesis of melanin is called melanogenesis and is regulated by various mechanisms and factors such as genetic, environmental and endocrine factors. The knowledge of the pigmentation process is important to understand hypopigmentation disorders such as vitiligo and also to design adequate treatments. In the present work, we review the signalling pathways involved in vitiligo. Finally, current therapies and treatments including topical, oral and phototherapies are discussed and described, emphasizing future therapies based on different pigmentation mechanisms.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2022;volume=67;issue=5;spage=524;epage=530;aulast=Vinardellhypopigmentationmelanin synthesismelanocytetreatmentvitiligo |
| spellingShingle | M Pilar Vinardell Adriana Solange Maddaleno Montserrat Mitjans Melanogenesis and hypopigmentation: The case of vitiligo Indian Journal of Dermatology hypopigmentation melanin synthesis melanocyte treatment vitiligo |
| title | Melanogenesis and hypopigmentation: The case of vitiligo |
| title_full | Melanogenesis and hypopigmentation: The case of vitiligo |
| title_fullStr | Melanogenesis and hypopigmentation: The case of vitiligo |
| title_full_unstemmed | Melanogenesis and hypopigmentation: The case of vitiligo |
| title_short | Melanogenesis and hypopigmentation: The case of vitiligo |
| title_sort | melanogenesis and hypopigmentation the case of vitiligo |
| topic | hypopigmentation melanin synthesis melanocyte treatment vitiligo |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2022;volume=67;issue=5;spage=524;epage=530;aulast=Vinardell |
| work_keys_str_mv | AT mpilarvinardell melanogenesisandhypopigmentationthecaseofvitiligo AT adrianasolangemaddaleno melanogenesisandhypopigmentationthecaseofvitiligo AT montserratmitjans melanogenesisandhypopigmentationthecaseofvitiligo |