Genome-Wide Analysis for Early Growth-Related Traits of the Locally Adapted Egyptian Barki Sheep
Sheep play a critical role in the agricultural and livestock sector in Egypt. For sheep meat production, growth traits such as birth and weaning weights are very important and determine the supply and income of local farmers. The Barki sheep originates from the northeastern coastal zone of Africa, a...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/8/1243 |
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| author | Ibrahim Abousoliman Henry Reyer Michael Oster Eduard Murani Ismail Mohamed Klaus Wimmers |
| author_facet | Ibrahim Abousoliman Henry Reyer Michael Oster Eduard Murani Ismail Mohamed Klaus Wimmers |
| author_sort | Ibrahim Abousoliman |
| collection | DOAJ |
| description | Sheep play a critical role in the agricultural and livestock sector in Egypt. For sheep meat production, growth traits such as birth and weaning weights are very important and determine the supply and income of local farmers. The Barki sheep originates from the northeastern coastal zone of Africa, and due to its good adaptation to the harsh environmental conditions, it contributes significantly to the meat production in these semi-arid regions. This study aimed to use a genome-wide SNP panel to identify genomic regions that are diversified between groups of individuals of Egyptian Barki sheep with high and low growth performance traits. In this context, from a phenotyped population of 140 lambs of Barki sheep, 69 lambs were considered for a genome-wide scan with the Illumina OvineSNP50 V2 BeadChip. The selected lambs were grouped into divergent subsets with significantly different performance for birth weight and weaning weight. After quality control, 63 animals and 40,383 SNPs were used for analysis. The fixation index (<i>F<sub>ST</sub></i>) for each SNP was calculated between the groups. The results verified genomic regions harboring some previously proposed candidate genes for traits related to body growth, i.e., <i>EYA2</i>, <i>GDF2</i>, <i>GDF10</i>, <i>MEF2B</i>, <i>SLC16A7</i>, <i>TBX15</i>, <i>TFAP2B</i>, and <i>TNNC2</i>. Moreover, novel candidate genes were proposed with known functional implications on growth processes such as <i>CPXM2</i> and <i>LRIG3</i>. Subsequent association analysis showed significant effects of the considered SNPs on birth and weaning weights. Results highlight the genetic diversity associated with performance traits and thus the potential to improve growth traits in the Barki sheep breed. |
| first_indexed | 2024-03-10T08:47:44Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T08:47:44Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-621cbaa566704df0b3e885619221e57f2023-11-22T07:46:35ZengMDPI AGGenes2073-44252021-08-01128124310.3390/genes12081243Genome-Wide Analysis for Early Growth-Related Traits of the Locally Adapted Egyptian Barki SheepIbrahim Abousoliman0Henry Reyer1Michael Oster2Eduard Murani3Ismail Mohamed4Klaus Wimmers5Leibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, GermanyLeibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, GermanyLeibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, GermanyLeibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, GermanyDesert Research Center, Department of Animal and Poultry Breeding, 1 Mathaf El-Matareya St., El-Matareya, Cairo 11753, EgyptLeibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, GermanySheep play a critical role in the agricultural and livestock sector in Egypt. For sheep meat production, growth traits such as birth and weaning weights are very important and determine the supply and income of local farmers. The Barki sheep originates from the northeastern coastal zone of Africa, and due to its good adaptation to the harsh environmental conditions, it contributes significantly to the meat production in these semi-arid regions. This study aimed to use a genome-wide SNP panel to identify genomic regions that are diversified between groups of individuals of Egyptian Barki sheep with high and low growth performance traits. In this context, from a phenotyped population of 140 lambs of Barki sheep, 69 lambs were considered for a genome-wide scan with the Illumina OvineSNP50 V2 BeadChip. The selected lambs were grouped into divergent subsets with significantly different performance for birth weight and weaning weight. After quality control, 63 animals and 40,383 SNPs were used for analysis. The fixation index (<i>F<sub>ST</sub></i>) for each SNP was calculated between the groups. The results verified genomic regions harboring some previously proposed candidate genes for traits related to body growth, i.e., <i>EYA2</i>, <i>GDF2</i>, <i>GDF10</i>, <i>MEF2B</i>, <i>SLC16A7</i>, <i>TBX15</i>, <i>TFAP2B</i>, and <i>TNNC2</i>. Moreover, novel candidate genes were proposed with known functional implications on growth processes such as <i>CPXM2</i> and <i>LRIG3</i>. Subsequent association analysis showed significant effects of the considered SNPs on birth and weaning weights. Results highlight the genetic diversity associated with performance traits and thus the potential to improve growth traits in the Barki sheep breed.https://www.mdpi.com/2073-4425/12/8/1243Barki sheepgrowthbirth weightweaning weightindigenous sheeplamb |
| spellingShingle | Ibrahim Abousoliman Henry Reyer Michael Oster Eduard Murani Ismail Mohamed Klaus Wimmers Genome-Wide Analysis for Early Growth-Related Traits of the Locally Adapted Egyptian Barki Sheep Genes Barki sheep growth birth weight weaning weight indigenous sheep lamb |
| title | Genome-Wide Analysis for Early Growth-Related Traits of the Locally Adapted Egyptian Barki Sheep |
| title_full | Genome-Wide Analysis for Early Growth-Related Traits of the Locally Adapted Egyptian Barki Sheep |
| title_fullStr | Genome-Wide Analysis for Early Growth-Related Traits of the Locally Adapted Egyptian Barki Sheep |
| title_full_unstemmed | Genome-Wide Analysis for Early Growth-Related Traits of the Locally Adapted Egyptian Barki Sheep |
| title_short | Genome-Wide Analysis for Early Growth-Related Traits of the Locally Adapted Egyptian Barki Sheep |
| title_sort | genome wide analysis for early growth related traits of the locally adapted egyptian barki sheep |
| topic | Barki sheep growth birth weight weaning weight indigenous sheep lamb |
| url | https://www.mdpi.com/2073-4425/12/8/1243 |
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