Insufficient HtrA2 causes meiotic defects in aging germinal vesicle oocytes

Insufficient HtrA2 causes meiotic defects in aging germinal vesicle oocytes

Abstract Background High-temperature requirement protease A2 (HtrA2/Omi) is a mitochondrial chaperone that is highly conserved from bacteria to humans. It plays an important role in mitochondrial homeostasis and apoptosis. In this study, we investigated the role of HtrA2 in mouse oocyte maturation....

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Bibliographic Details
Main Authors: Min Gao, Yanling Qiu, Tianqi Cao, Dungao Li, Jingwen Wang, Yiren Jiao, Zhiyun Chen, Junjiu Huang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Reproductive Biology and Endocrinology
Subjects:
Aging
HtrA2
Germinal vesicle oocyte
Maturation
Meiosis
Online Access:https://doi.org/10.1186/s12958-022-01048-4

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