Ectopic Ossification in the Scar Tissue of Rats with Myocardial Infarction
We describe the occurrence of bone-like formations in the left ventricular wall of infarcted rats treated or not with bone marrow cells injected systemically or locally into the myocardium. The incidence of ectopic calcification in hearts has been reported in rare cases in children with infarcts wit...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2006-05-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.3727/000000006783981864 |
| _version_ | 1818995439977889792 |
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| author | Karla Consort Ribeiro Elisabete César Mattos João Pedro Saar Werneck-de-Castro Vanessa Pinho Ribeiro Ricardo Henrique Costa-e-Sousa Amarildo Miranda Emerson Lopes Olivares Marcos Farina José Geraldo Mill Regina Coeli dos Santos Goldenberg Masako Oya Masuda Antônio Carlos Campos de Carvalho |
| author_facet | Karla Consort Ribeiro Elisabete César Mattos João Pedro Saar Werneck-de-Castro Vanessa Pinho Ribeiro Ricardo Henrique Costa-e-Sousa Amarildo Miranda Emerson Lopes Olivares Marcos Farina José Geraldo Mill Regina Coeli dos Santos Goldenberg Masako Oya Masuda Antônio Carlos Campos de Carvalho |
| author_sort | Karla Consort Ribeiro |
| collection | DOAJ |
| description | We describe the occurrence of bone-like formations in the left ventricular wall of infarcted rats treated or not with bone marrow cells injected systemically or locally into the myocardium. The incidence of ectopic calcification in hearts has been reported in rare cases in children with infarcts without previous coronary artery disease. Recently, ventricular calcification has been correlated with unselected bone marrow cell transplantation into infarcted rat hearts. Echocardiographic analysis of large infarction in rats frequently reveals the presence of echogenic structures in the left ventricular wall, sometimes projecting to the lumen of the chamber. The histological examination of these echogenic structures exhibited bone, cartilage, and marrowlike formations extending from the collagen-rich matrix of the ventricle wall. Microanalytical techniques verified the presence of hydroxyapatite in the mineral phase. Ossification was found in 25 out of 30 hearts evaluated 90 days postinfarct, being observed in 14 out of 17 animals submitted to cell therapy and in 11 out of 13 infarcted rats not submitted to cell therapy. Our study indicates that chondro-osteogenic differentiation can take place in the pathological rat heart independent of animal treatment with marrow cells. |
| first_indexed | 2024-12-20T21:13:52Z |
| format | Article |
| id | doaj.art-621db3e012f341eea6b322f75fbd9c52 |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-20T21:13:52Z |
| publishDate | 2006-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-621db3e012f341eea6b322f75fbd9c522022-12-21T19:26:28ZengSAGE PublishingCell Transplantation0963-68971555-38922006-05-011510.3727/000000006783981864Ectopic Ossification in the Scar Tissue of Rats with Myocardial InfarctionKarla Consort Ribeiro0Elisabete César Mattos1João Pedro Saar Werneck-de-Castro2Vanessa Pinho Ribeiro3Ricardo Henrique Costa-e-Sousa4Amarildo Miranda5Emerson Lopes Olivares6Marcos Farina7José Geraldo Mill8Regina Coeli dos Santos Goldenberg9Masako Oya Masuda10Antônio Carlos Campos de Carvalho11Instituto de Biofísica Carlos Chagas Filho UFRJ-CCS, Bloco G, Ilha do Fundão, Rio de Janeiro, BrasilEcodata Exames Médicos LTDA, Rio de Janeiro, BrasilInstituto de Biofísica Carlos Chagas Filho UFRJ-CCS, Bloco G, Ilha do Fundão, Rio de Janeiro, BrasilInstituto de Biofísica Carlos Chagas Filho UFRJ-CCS, Bloco G, Ilha do Fundão, Rio de Janeiro, BrasilInstituto de Biofísica Carlos Chagas Filho UFRJ-CCS, Bloco G, Ilha do Fundão, Rio de Janeiro, BrasilInstituto de Biofísica Carlos Chagas Filho UFRJ-CCS, Bloco G, Ilha do Fundão, Rio de Janeiro, BrasilInstituto de Biofísica Carlos Chagas Filho UFRJ-CCS, Bloco G, Ilha do Fundão, Rio de Janeiro, BrasilInstituto de Ciências Biomédicas UFRJ-CCS, Bloco F, Ilha do Fundão, Rio de Janeiro, BrasilDepartamento de Ciências Fisiológicas UFES, Vitória, BrasilInstituto de Biofísica Carlos Chagas Filho UFRJ-CCS, Bloco G, Ilha do Fundão, Rio de Janeiro, BrasilInstituto de Biofísica Carlos Chagas Filho UFRJ-CCS, Bloco G, Ilha do Fundão, Rio de Janeiro, BrasilInstituto Nacional de Cardiologia Laranjeiras, Rio de Janeiro, BrasilWe describe the occurrence of bone-like formations in the left ventricular wall of infarcted rats treated or not with bone marrow cells injected systemically or locally into the myocardium. The incidence of ectopic calcification in hearts has been reported in rare cases in children with infarcts without previous coronary artery disease. Recently, ventricular calcification has been correlated with unselected bone marrow cell transplantation into infarcted rat hearts. Echocardiographic analysis of large infarction in rats frequently reveals the presence of echogenic structures in the left ventricular wall, sometimes projecting to the lumen of the chamber. The histological examination of these echogenic structures exhibited bone, cartilage, and marrowlike formations extending from the collagen-rich matrix of the ventricle wall. Microanalytical techniques verified the presence of hydroxyapatite in the mineral phase. Ossification was found in 25 out of 30 hearts evaluated 90 days postinfarct, being observed in 14 out of 17 animals submitted to cell therapy and in 11 out of 13 infarcted rats not submitted to cell therapy. Our study indicates that chondro-osteogenic differentiation can take place in the pathological rat heart independent of animal treatment with marrow cells.https://doi.org/10.3727/000000006783981864 |
| spellingShingle | Karla Consort Ribeiro Elisabete César Mattos João Pedro Saar Werneck-de-Castro Vanessa Pinho Ribeiro Ricardo Henrique Costa-e-Sousa Amarildo Miranda Emerson Lopes Olivares Marcos Farina José Geraldo Mill Regina Coeli dos Santos Goldenberg Masako Oya Masuda Antônio Carlos Campos de Carvalho Ectopic Ossification in the Scar Tissue of Rats with Myocardial Infarction Cell Transplantation |
| title | Ectopic Ossification in the Scar Tissue of Rats with Myocardial Infarction |
| title_full | Ectopic Ossification in the Scar Tissue of Rats with Myocardial Infarction |
| title_fullStr | Ectopic Ossification in the Scar Tissue of Rats with Myocardial Infarction |
| title_full_unstemmed | Ectopic Ossification in the Scar Tissue of Rats with Myocardial Infarction |
| title_short | Ectopic Ossification in the Scar Tissue of Rats with Myocardial Infarction |
| title_sort | ectopic ossification in the scar tissue of rats with myocardial infarction |
| url | https://doi.org/10.3727/000000006783981864 |
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