Surface Contamination with Cyclophosphamide and Iphosphamide in Chemotherapy Centers
Background and purpose: Cyclophosphamide and ifosfamide are two most widely used and hazardous drugs in chemotherapy centers. This study aimed at determining surface contamination with cyclophosphamide and iphosphamide in chemotherapy centers. Materials and methods: This descriptive cross-sectional...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mazandaran University of Medical Sciences
2018-06-01
|
| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-10304-en.html |
| _version_ | 1828054854533120000 |
|---|---|
| author | Hamideh Deljou Mohammad Javad Assari Abdolraman Bahrami Mohammad Zolhavarieh |
| author_facet | Hamideh Deljou Mohammad Javad Assari Abdolraman Bahrami Mohammad Zolhavarieh |
| author_sort | Hamideh Deljou |
| collection | DOAJ |
| description | Background and purpose: Cyclophosphamide and ifosfamide are two most widely used and hazardous drugs in chemotherapy centers. This study aimed at determining surface contamination with cyclophosphamide and iphosphamide in chemotherapy centers.
Materials and methods: This descriptive cross-sectional study was carried out in three chemotherapy centers affiliated with Hamedan University of Medical Sciences, Iran 2016. Twenty eight samples were collected from contaminated surfaces. The samples were then prepared by solid phase extraction and analyzed by HPLC/UV apparatus.
Results: The mean values for surface contamination of cyclophosphamide and ifosfamide were 57.28 ± 63.8 and 44.15 ± 5.5 ng/cm2, respectively. The highest levels of contamination with both drugs were observed at exhaust hood surfaces and the lowest level of contamination was seen in nursing station and staff resting place. The clothes and gloves of nurses were also found to be contaminated.
Conclusion: Daily number of medications, the location of drug preparation room and injection room, nursing station, staff resting place, daily cleaning programs, and repairing and maintenance of ventilation systems were amongst the major factors affecting surface contamination in chemotherapy centers. |
| first_indexed | 2024-04-10T20:29:32Z |
| format | Article |
| id | doaj.art-621e0aadcb5a4af29f8a1edc1f74a636 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:29:32Z |
| publishDate | 2018-06-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-621e0aadcb5a4af29f8a1edc1f74a6362023-01-25T07:33:19ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792018-06-0128161133137Surface Contamination with Cyclophosphamide and Iphosphamide in Chemotherapy CentersHamideh Deljou0Mohammad Javad Assari1Abdolraman Bahrami2Mohammad Zolhavarieh3 MSc Student in Occupational Hygiene, Center of Excellence for Occupational Health, Research Center for Health Sciences, Faculty of Public Health, Hamedan University of Medical Sciences, Hamedan, Iran Assistant Professor, Center of Excellence for Occupational Health, Research Center for Health Sciences, Faculty of Public Health, Hamedan University of Medical Sciences, Hamedan, Iran Professor, Center of Excellence for Occupational Health, Occupational Safety and Health Research Center, Faculty of Public Health, Hamedan University of Medical Sciences, Hamedan, Iran Assistant Professor, Department of Anesthesiology, Faculty of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran Background and purpose: Cyclophosphamide and ifosfamide are two most widely used and hazardous drugs in chemotherapy centers. This study aimed at determining surface contamination with cyclophosphamide and iphosphamide in chemotherapy centers. Materials and methods: This descriptive cross-sectional study was carried out in three chemotherapy centers affiliated with Hamedan University of Medical Sciences, Iran 2016. Twenty eight samples were collected from contaminated surfaces. The samples were then prepared by solid phase extraction and analyzed by HPLC/UV apparatus. Results: The mean values for surface contamination of cyclophosphamide and ifosfamide were 57.28 ± 63.8 and 44.15 ± 5.5 ng/cm2, respectively. The highest levels of contamination with both drugs were observed at exhaust hood surfaces and the lowest level of contamination was seen in nursing station and staff resting place. The clothes and gloves of nurses were also found to be contaminated. Conclusion: Daily number of medications, the location of drug preparation room and injection room, nursing station, staff resting place, daily cleaning programs, and repairing and maintenance of ventilation systems were amongst the major factors affecting surface contamination in chemotherapy centers.http://jmums.mazums.ac.ir/article-1-10304-en.htmldrug therapycyclophosphamideifosfamideoccupational exposureenvironmental monitoringhospitals |
| spellingShingle | Hamideh Deljou Mohammad Javad Assari Abdolraman Bahrami Mohammad Zolhavarieh Surface Contamination with Cyclophosphamide and Iphosphamide in Chemotherapy Centers Journal of Mazandaran University of Medical Sciences drug therapy cyclophosphamide ifosfamide occupational exposure environmental monitoring hospitals |
| title | Surface Contamination with Cyclophosphamide and Iphosphamide in Chemotherapy Centers |
| title_full | Surface Contamination with Cyclophosphamide and Iphosphamide in Chemotherapy Centers |
| title_fullStr | Surface Contamination with Cyclophosphamide and Iphosphamide in Chemotherapy Centers |
| title_full_unstemmed | Surface Contamination with Cyclophosphamide and Iphosphamide in Chemotherapy Centers |
| title_short | Surface Contamination with Cyclophosphamide and Iphosphamide in Chemotherapy Centers |
| title_sort | surface contamination with cyclophosphamide and iphosphamide in chemotherapy centers |
| topic | drug therapy cyclophosphamide ifosfamide occupational exposure environmental monitoring hospitals |
| url | http://jmums.mazums.ac.ir/article-1-10304-en.html |
| work_keys_str_mv | AT hamidehdeljou surfacecontaminationwithcyclophosphamideandiphosphamideinchemotherapycenters AT mohammadjavadassari surfacecontaminationwithcyclophosphamideandiphosphamideinchemotherapycenters AT abdolramanbahrami surfacecontaminationwithcyclophosphamideandiphosphamideinchemotherapycenters AT mohammadzolhavarieh surfacecontaminationwithcyclophosphamideandiphosphamideinchemotherapycenters |