Detection of Mycoplasma pneumoniae and Chlamydia pneumoniae in ruptured atherosclerotic plaques
This paper reports what is apparently the first observation of Mycoplasma pneumoniae in association with Chlamydia pneumoniae in thrombosed ruptured atheromas. We performed electron microscopy and in situ hybridization in specimens from three patients who died of acute myocardial infarction. These p...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2000-09-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900005 |
| _version_ | 1818941528150638592 |
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| author | M.L. Higuchi N. Sambiase S. Palomino P. Gutierrez L.M. Demarchi V.D. Aiello J.A.F. Ramires |
| author_facet | M.L. Higuchi N. Sambiase S. Palomino P. Gutierrez L.M. Demarchi V.D. Aiello J.A.F. Ramires |
| author_sort | M.L. Higuchi |
| collection | DOAJ |
| description | This paper reports what is apparently the first observation of Mycoplasma pneumoniae in association with Chlamydia pneumoniae in thrombosed ruptured atheromas. We performed electron microscopy and in situ hybridization in specimens from three patients who died of acute myocardial infarction. These patients had typical symptoms of acute ischemic syndrome. Mycoplasmas were present mainly in the lipid core of the ruptured thrombosed plaque. Vulnerable atheromas are rich in cholesterol and may favor the growth of mycoplasmas, the only microorganisms that require cholesterol for survival. We suggest that the association of Mycoplasma pneumoniae and Chlamydia pneumoniae may increase the virulence of these microorganisms, favoring proliferation, plaque inflammation and possibly plaque rupture. |
| first_indexed | 2024-12-20T06:56:58Z |
| format | Article |
| id | doaj.art-6221207a3d564d9da8ce7c71d609ece0 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-20T06:56:58Z |
| publishDate | 2000-09-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-6221207a3d564d9da8ce7c71d609ece02022-12-21T19:49:18ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2000-09-013391023102610.1590/S0100-879X2000000900005Detection of Mycoplasma pneumoniae and Chlamydia pneumoniae in ruptured atherosclerotic plaquesM.L. HiguchiN. SambiaseS. PalominoP. GutierrezL.M. DemarchiV.D. AielloJ.A.F. RamiresThis paper reports what is apparently the first observation of Mycoplasma pneumoniae in association with Chlamydia pneumoniae in thrombosed ruptured atheromas. We performed electron microscopy and in situ hybridization in specimens from three patients who died of acute myocardial infarction. These patients had typical symptoms of acute ischemic syndrome. Mycoplasmas were present mainly in the lipid core of the ruptured thrombosed plaque. Vulnerable atheromas are rich in cholesterol and may favor the growth of mycoplasmas, the only microorganisms that require cholesterol for survival. We suggest that the association of Mycoplasma pneumoniae and Chlamydia pneumoniae may increase the virulence of these microorganisms, favoring proliferation, plaque inflammation and possibly plaque rupture.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900005Mycoplasma pneumoniaeChlamydia pneumoniaeatherosclerosisvulnerable plaqueinflammation |
| spellingShingle | M.L. Higuchi N. Sambiase S. Palomino P. Gutierrez L.M. Demarchi V.D. Aiello J.A.F. Ramires Detection of Mycoplasma pneumoniae and Chlamydia pneumoniae in ruptured atherosclerotic plaques Brazilian Journal of Medical and Biological Research Mycoplasma pneumoniae Chlamydia pneumoniae atherosclerosis vulnerable plaque inflammation |
| title | Detection of Mycoplasma pneumoniae and Chlamydia pneumoniae in ruptured atherosclerotic plaques |
| title_full | Detection of Mycoplasma pneumoniae and Chlamydia pneumoniae in ruptured atherosclerotic plaques |
| title_fullStr | Detection of Mycoplasma pneumoniae and Chlamydia pneumoniae in ruptured atherosclerotic plaques |
| title_full_unstemmed | Detection of Mycoplasma pneumoniae and Chlamydia pneumoniae in ruptured atherosclerotic plaques |
| title_short | Detection of Mycoplasma pneumoniae and Chlamydia pneumoniae in ruptured atherosclerotic plaques |
| title_sort | detection of mycoplasma pneumoniae and chlamydia pneumoniae in ruptured atherosclerotic plaques |
| topic | Mycoplasma pneumoniae Chlamydia pneumoniae atherosclerosis vulnerable plaque inflammation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900005 |
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