Mongolian medicine Mingmu-11 Pills combined with Conbercept in the treatment of wet age-related macular degeneration
AIM: To evaluate the clinical efficacy of Mongolian medicine Mingmu-11 Pills combined with conbercept in the treatment of wet age-related macular degeneration(wARMD).METHODS: Prospective study. All cases in this study were wARMD patients(72 cases, 72 eyes)admitted to the Ophthalmology Department of...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2024-05-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2024/5/202405006.pdf |
| _version_ | 1797194662939721728 |
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| author | Su Riguga Ran Linlin Xiao Qin |
| author_facet | Su Riguga Ran Linlin Xiao Qin |
| author_sort | Su Riguga |
| collection | DOAJ |
| description | AIM: To evaluate the clinical efficacy of Mongolian medicine Mingmu-11 Pills combined with conbercept in the treatment of wet age-related macular degeneration(wARMD).METHODS: Prospective study. All cases in this study were wARMD patients(72 cases, 72 eyes)admitted to the Ophthalmology Department of Affiliated Hospital of Inner Mongolia University from November 2020 to December 2021. They were randomly divided into a combined treatment group and a control group, each with 36 eyes, and the control group received intravitreal injection of conbercept 0.05 mL for 3 consecutive months. The combined treatment group was given Mingmu-11 Pills twice a day after surgery, with 3 wk as a course of treatment, a total of 3 courses, and the control group was not given Mongolian medicine treatment. The best corrected visual acuity(BCVA), changes in central macular thickness(CMT)in the macular area, and changes in N1, P1 wave amplitude density and latency were observed after treatment in both groups.RESULTS:The BCVA(letter number)of the two groups were improved(P<0.05), and the CMT were decreased(P<0.05). The improvement of BCVA(letter number)in the combined treatment group was better than that in the control group at 3 mo(17.42±3.29 vs 14.61±3.14, P<0.001)and 5 mo(19.75±3.25 vs 16.81±2.77, P<0.001)after treatment; compared with the control group, CMT of the combined treatment group was thinner than that of the control group at 3 mo(304.58±53.34 vs 351.94±52.99 μm, P<0.001)and 5 mo(274.17±62.26 vs 321.78±63.22 μm, P<0.05)after treatment. The amplitude density of N1 and P1 wave in mfERG in both groups at 3 mo after treatment was higher than that before treatment(P<0.05), and r1-r3 latency of P1 wave was shorter than that before treatment(P<0.05), with no differences in the r1-r3 latency of N1 wave(P>0.05). In addition, the amplitude density of N1 and P1 wave in the combined treatment group was higher than that in the control group at 3 mo after treatment(P<0.05), the latency of P1 wave in the treatment group was significantly shorter than that in the control group(P<0.05), and there was no significant difference in the latency of N1 wave between the two groups(P>0.05).CONCLUSIONS:Mingmu-11 Pills combined with intravitreal injection of conbercept in the treatment of wARMD has obvious efficacy in improving vision and reducing macular edema. |
| first_indexed | 2024-04-24T05:59:51Z |
| format | Article |
| id | doaj.art-62222c52a0fc42d380524859100b37c6 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-04-24T05:59:51Z |
| publishDate | 2024-05-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-62222c52a0fc42d380524859100b37c62024-04-23T08:29:23ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232024-05-0124569169610.3980/j.issn.1672-5123.2024.5.06202405006Mongolian medicine Mingmu-11 Pills combined with Conbercept in the treatment of wet age-related macular degenerationSu Riguga0Ran Linlin1Xiao Qin2Department of Medicine, Xilingol Vocational College, Xilinhot 026000, Inner Mongolia Autonomous Region, China; Department of Ophthalmology, Affiliated Hospital of Inner Mongolia Minzu University, Tongliao 028000, Inner Mongolia Autonomous Region, ChinaDepartment of Ophthalmology, Chifeng City Hospital of Traditional Chinese Medicine and Mongolian Medicine, Chifeng 024000, Inner Mongolia Autonomous Region, ChinaDepartment of Ophthalmology, Affiliated Hospital of Inner Mongolia Minzu University, Tongliao 028000, Inner Mongolia Autonomous Region, ChinaAIM: To evaluate the clinical efficacy of Mongolian medicine Mingmu-11 Pills combined with conbercept in the treatment of wet age-related macular degeneration(wARMD).METHODS: Prospective study. All cases in this study were wARMD patients(72 cases, 72 eyes)admitted to the Ophthalmology Department of Affiliated Hospital of Inner Mongolia University from November 2020 to December 2021. They were randomly divided into a combined treatment group and a control group, each with 36 eyes, and the control group received intravitreal injection of conbercept 0.05 mL for 3 consecutive months. The combined treatment group was given Mingmu-11 Pills twice a day after surgery, with 3 wk as a course of treatment, a total of 3 courses, and the control group was not given Mongolian medicine treatment. The best corrected visual acuity(BCVA), changes in central macular thickness(CMT)in the macular area, and changes in N1, P1 wave amplitude density and latency were observed after treatment in both groups.RESULTS:The BCVA(letter number)of the two groups were improved(P<0.05), and the CMT were decreased(P<0.05). The improvement of BCVA(letter number)in the combined treatment group was better than that in the control group at 3 mo(17.42±3.29 vs 14.61±3.14, P<0.001)and 5 mo(19.75±3.25 vs 16.81±2.77, P<0.001)after treatment; compared with the control group, CMT of the combined treatment group was thinner than that of the control group at 3 mo(304.58±53.34 vs 351.94±52.99 μm, P<0.001)and 5 mo(274.17±62.26 vs 321.78±63.22 μm, P<0.05)after treatment. The amplitude density of N1 and P1 wave in mfERG in both groups at 3 mo after treatment was higher than that before treatment(P<0.05), and r1-r3 latency of P1 wave was shorter than that before treatment(P<0.05), with no differences in the r1-r3 latency of N1 wave(P>0.05). In addition, the amplitude density of N1 and P1 wave in the combined treatment group was higher than that in the control group at 3 mo after treatment(P<0.05), the latency of P1 wave in the treatment group was significantly shorter than that in the control group(P<0.05), and there was no significant difference in the latency of N1 wave between the two groups(P>0.05).CONCLUSIONS:Mingmu-11 Pills combined with intravitreal injection of conbercept in the treatment of wARMD has obvious efficacy in improving vision and reducing macular edema.http://ies.ijo.cn/cn_publish/2024/5/202405006.pdfmongolian medicine mingmu-11 pillswet age-related macular degenerationmacular edemaconbercept |
| spellingShingle | Su Riguga Ran Linlin Xiao Qin Mongolian medicine Mingmu-11 Pills combined with Conbercept in the treatment of wet age-related macular degeneration Guoji Yanke Zazhi mongolian medicine mingmu-11 pills wet age-related macular degeneration macular edema conbercept |
| title | Mongolian medicine Mingmu-11 Pills combined with Conbercept in the treatment of wet age-related macular degeneration |
| title_full | Mongolian medicine Mingmu-11 Pills combined with Conbercept in the treatment of wet age-related macular degeneration |
| title_fullStr | Mongolian medicine Mingmu-11 Pills combined with Conbercept in the treatment of wet age-related macular degeneration |
| title_full_unstemmed | Mongolian medicine Mingmu-11 Pills combined with Conbercept in the treatment of wet age-related macular degeneration |
| title_short | Mongolian medicine Mingmu-11 Pills combined with Conbercept in the treatment of wet age-related macular degeneration |
| title_sort | mongolian medicine mingmu 11 pills combined with conbercept in the treatment of wet age related macular degeneration |
| topic | mongolian medicine mingmu-11 pills wet age-related macular degeneration macular edema conbercept |
| url | http://ies.ijo.cn/cn_publish/2024/5/202405006.pdf |
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