Circulating predictive markers of immune checkpoint inhibitors in non-small cell lung cancer
Immune checkpoint inhibitors (ICIs) alone or in combination with chemotherapy have become one of the key approaches in the treatment of patients with advanced non-small cell lung cancer (NSCLC). Evaluation of level of PD-L1 (ligand of the programmed cell death receptor 1) expression on tumor cells u...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2021-11-01
|
| Series: | Успехи молекулярной онкологии |
| Subjects: | |
| Online Access: | https://umo.abvpress.ru/jour/article/view/378 |
| _version_ | 1797759388777185280 |
|---|---|
| author | A. A. Musaelyan A. L. Akopov S. V. Lapin V. D. Nazarov D. I. Fillipov V. L. Emanuel S. V. Orlov |
| author_facet | A. A. Musaelyan A. L. Akopov S. V. Lapin V. D. Nazarov D. I. Fillipov V. L. Emanuel S. V. Orlov |
| author_sort | A. A. Musaelyan |
| collection | DOAJ |
| description | Immune checkpoint inhibitors (ICIs) alone or in combination with chemotherapy have become one of the key approaches in the treatment of patients with advanced non-small cell lung cancer (NSCLC). Evaluation of level of PD-L1 (ligand of the programmed cell death receptor 1) expression on tumor cells using immunohistochemistry is the only approved option for determining the indications of ICIs in this group of patients. However, despite high level of PD-L1 expression, up to 80 % of patients do not respond to therapy due to the presence of primary or acquired resistance, which determines the limited effectiveness of ICI. In addition, 8–17 % of PD-L1-negative patients with NSCLC are also able to respond to ICIs. The limitation of this marker is that it does not allow assessing both intratumoral and systemic immune status. It is necessary to search for additional predictive markers to improve the accuracy of the selection of candidates for immunotherapy, which will avoid costs, wasted time, and a high risk of immune-related adverse events in potentially unresponsive patients. The attention of researchers is devoted to circulating markers in peripheral blood, as a non-invasive alternative to biopsy for predicting and monitoring the response. This review focuses on the most promising immunological markers in peripheral blood as potential predictors of response to ICIs in patients with advanced NSCLC. |
| first_indexed | 2024-03-12T18:43:44Z |
| format | Article |
| id | doaj.art-62229f8a1c4346e2b9b5224260d6307e |
| institution | Directory Open Access Journal |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| last_indexed | 2024-03-12T18:43:44Z |
| publishDate | 2021-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj.art-62229f8a1c4346e2b9b5224260d6307e2023-08-02T07:48:01ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872021-11-0183344310.17650/2313-805X-2021-8-3-34-43216Circulating predictive markers of immune checkpoint inhibitors in non-small cell lung cancerA. A. Musaelyan0A. L. Akopov1S. V. Lapin2V. D. Nazarov3D. I. Fillipov4V. L. Emanuel5S. V. Orlov6ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России; ФГБНУ «Научно-исследовательский институт медицинской приматологии»ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава РоссииФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава РоссииФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава РоссииФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава РоссииФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава РоссииФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России; ФГБНУ «Научно-исследовательский институт медицинской приматологии»Immune checkpoint inhibitors (ICIs) alone or in combination with chemotherapy have become one of the key approaches in the treatment of patients with advanced non-small cell lung cancer (NSCLC). Evaluation of level of PD-L1 (ligand of the programmed cell death receptor 1) expression on tumor cells using immunohistochemistry is the only approved option for determining the indications of ICIs in this group of patients. However, despite high level of PD-L1 expression, up to 80 % of patients do not respond to therapy due to the presence of primary or acquired resistance, which determines the limited effectiveness of ICI. In addition, 8–17 % of PD-L1-negative patients with NSCLC are also able to respond to ICIs. The limitation of this marker is that it does not allow assessing both intratumoral and systemic immune status. It is necessary to search for additional predictive markers to improve the accuracy of the selection of candidates for immunotherapy, which will avoid costs, wasted time, and a high risk of immune-related adverse events in potentially unresponsive patients. The attention of researchers is devoted to circulating markers in peripheral blood, as a non-invasive alternative to biopsy for predicting and monitoring the response. This review focuses on the most promising immunological markers in peripheral blood as potential predictors of response to ICIs in patients with advanced NSCLC.https://umo.abvpress.ru/jour/article/view/378предиктивные маркерынемелкоклеточный рак легкогоиммунотерапиялиганд рецептора запрограммированной клеточной гибели 1 |
| spellingShingle | A. A. Musaelyan A. L. Akopov S. V. Lapin V. D. Nazarov D. I. Fillipov V. L. Emanuel S. V. Orlov Circulating predictive markers of immune checkpoint inhibitors in non-small cell lung cancer Успехи молекулярной онкологии предиктивные маркеры немелкоклеточный рак легкого иммунотерапия лиганд рецептора запрограммированной клеточной гибели 1 |
| title | Circulating predictive markers of immune checkpoint inhibitors in non-small cell lung cancer |
| title_full | Circulating predictive markers of immune checkpoint inhibitors in non-small cell lung cancer |
| title_fullStr | Circulating predictive markers of immune checkpoint inhibitors in non-small cell lung cancer |
| title_full_unstemmed | Circulating predictive markers of immune checkpoint inhibitors in non-small cell lung cancer |
| title_short | Circulating predictive markers of immune checkpoint inhibitors in non-small cell lung cancer |
| title_sort | circulating predictive markers of immune checkpoint inhibitors in non small cell lung cancer |
| topic | предиктивные маркеры немелкоклеточный рак легкого иммунотерапия лиганд рецептора запрограммированной клеточной гибели 1 |
| url | https://umo.abvpress.ru/jour/article/view/378 |
| work_keys_str_mv | AT aamusaelyan circulatingpredictivemarkersofimmunecheckpointinhibitorsinnonsmallcelllungcancer AT alakopov circulatingpredictivemarkersofimmunecheckpointinhibitorsinnonsmallcelllungcancer AT svlapin circulatingpredictivemarkersofimmunecheckpointinhibitorsinnonsmallcelllungcancer AT vdnazarov circulatingpredictivemarkersofimmunecheckpointinhibitorsinnonsmallcelllungcancer AT difillipov circulatingpredictivemarkersofimmunecheckpointinhibitorsinnonsmallcelllungcancer AT vlemanuel circulatingpredictivemarkersofimmunecheckpointinhibitorsinnonsmallcelllungcancer AT svorlov circulatingpredictivemarkersofimmunecheckpointinhibitorsinnonsmallcelllungcancer |