Inorganic Nanomaterials with Intrinsic Singlet Oxygen Generation for Photodynamic Therapy
Abstract Inorganic nanomaterials with intrinsic singlet oxygen (1O2) generation capacity, are emerged yet dynamically developing materials as nano‐photosensitizers (NPSs) for photodynamic therapy (PDT). Compared to previously reported nanomaterials that have been used as either carriers to load orga...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-11-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202102587 |
| _version_ | 1819114537840803840 |
|---|---|
| author | Muhammad Rizwan Younis Gang He Junle Qu Jing Lin Peng Huang Xing‐Hua Xia |
| author_facet | Muhammad Rizwan Younis Gang He Junle Qu Jing Lin Peng Huang Xing‐Hua Xia |
| author_sort | Muhammad Rizwan Younis |
| collection | DOAJ |
| description | Abstract Inorganic nanomaterials with intrinsic singlet oxygen (1O2) generation capacity, are emerged yet dynamically developing materials as nano‐photosensitizers (NPSs) for photodynamic therapy (PDT). Compared to previously reported nanomaterials that have been used as either carriers to load organic PSs or energy donors to excite the attached organic PSs through a Foster resonance energy transfer process, these NPSs possess intrinsic 1O2 generation capacity with extremely high 1O2 quantum yield (e.g., 1.56, 1.3, 1.26, and 1.09) than any classical organic PS reported to date, and thus are facilitating to make a revolution in PDT. In this review, the recent advances in the development of various inorganic nanomaterials as NPSs, including metal‐based (gold, silver, and tungsten), metal oxide‐based (titanium dioxide, tungsten oxide, and bismuth oxyhalide), metal sulfide‐based (copper and molybdenum sulfide), carbon‐based (graphene, fullerene, and graphitic carbon nitride), phosphorus‐based, and others (hybrids and MXenes‐based NPSs) are summarized, with an emphasis on the design principle and 1O2 generation mechanism, and the photodynamic therapeutic performance against different types of cancers. Finally, the current challenges and an outlook of future research are also discussed. This review may provide a comprehensive account capable of explaining recent progress as well as future research of this emerging paradigm. |
| first_indexed | 2024-12-22T04:46:53Z |
| format | Article |
| id | doaj.art-62231dd3e0c440c0ae3ba3a6ec25ea90 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-22T04:46:53Z |
| publishDate | 2021-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-62231dd3e0c440c0ae3ba3a6ec25ea902022-12-21T18:38:35ZengWileyAdvanced Science2198-38442021-11-01821n/an/a10.1002/advs.202102587Inorganic Nanomaterials with Intrinsic Singlet Oxygen Generation for Photodynamic TherapyMuhammad Rizwan Younis0Gang He1Junle Qu2Jing Lin3Peng Huang4Xing‐Hua Xia5Marshall Laboratory of Biomedical Engineering International Cancer Center Laboratory of Evolutionary Theranostics (LET) School of Biomedical Engineering Shenzhen University Health Science Center Shenzhen 518060 ChinaMarshall Laboratory of Biomedical Engineering International Cancer Center Laboratory of Evolutionary Theranostics (LET) School of Biomedical Engineering Shenzhen University Health Science Center Shenzhen 518060 ChinaKey Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic Engineering Shenzhen University Shenzhen 518060 ChinaMarshall Laboratory of Biomedical Engineering International Cancer Center Laboratory of Evolutionary Theranostics (LET) School of Biomedical Engineering Shenzhen University Health Science Center Shenzhen 518060 ChinaMarshall Laboratory of Biomedical Engineering International Cancer Center Laboratory of Evolutionary Theranostics (LET) School of Biomedical Engineering Shenzhen University Health Science Center Shenzhen 518060 ChinaState Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences School of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 P.R. ChinaAbstract Inorganic nanomaterials with intrinsic singlet oxygen (1O2) generation capacity, are emerged yet dynamically developing materials as nano‐photosensitizers (NPSs) for photodynamic therapy (PDT). Compared to previously reported nanomaterials that have been used as either carriers to load organic PSs or energy donors to excite the attached organic PSs through a Foster resonance energy transfer process, these NPSs possess intrinsic 1O2 generation capacity with extremely high 1O2 quantum yield (e.g., 1.56, 1.3, 1.26, and 1.09) than any classical organic PS reported to date, and thus are facilitating to make a revolution in PDT. In this review, the recent advances in the development of various inorganic nanomaterials as NPSs, including metal‐based (gold, silver, and tungsten), metal oxide‐based (titanium dioxide, tungsten oxide, and bismuth oxyhalide), metal sulfide‐based (copper and molybdenum sulfide), carbon‐based (graphene, fullerene, and graphitic carbon nitride), phosphorus‐based, and others (hybrids and MXenes‐based NPSs) are summarized, with an emphasis on the design principle and 1O2 generation mechanism, and the photodynamic therapeutic performance against different types of cancers. Finally, the current challenges and an outlook of future research are also discussed. This review may provide a comprehensive account capable of explaining recent progress as well as future research of this emerging paradigm.https://doi.org/10.1002/advs.202102587extinction coefficientnano‐photosensitizersphotodynamic therapyquantum yieldsinglet oxygen |
| spellingShingle | Muhammad Rizwan Younis Gang He Junle Qu Jing Lin Peng Huang Xing‐Hua Xia Inorganic Nanomaterials with Intrinsic Singlet Oxygen Generation for Photodynamic Therapy Advanced Science extinction coefficient nano‐photosensitizers photodynamic therapy quantum yield singlet oxygen |
| title | Inorganic Nanomaterials with Intrinsic Singlet Oxygen Generation for Photodynamic Therapy |
| title_full | Inorganic Nanomaterials with Intrinsic Singlet Oxygen Generation for Photodynamic Therapy |
| title_fullStr | Inorganic Nanomaterials with Intrinsic Singlet Oxygen Generation for Photodynamic Therapy |
| title_full_unstemmed | Inorganic Nanomaterials with Intrinsic Singlet Oxygen Generation for Photodynamic Therapy |
| title_short | Inorganic Nanomaterials with Intrinsic Singlet Oxygen Generation for Photodynamic Therapy |
| title_sort | inorganic nanomaterials with intrinsic singlet oxygen generation for photodynamic therapy |
| topic | extinction coefficient nano‐photosensitizers photodynamic therapy quantum yield singlet oxygen |
| url | https://doi.org/10.1002/advs.202102587 |
| work_keys_str_mv | AT muhammadrizwanyounis inorganicnanomaterialswithintrinsicsingletoxygengenerationforphotodynamictherapy AT ganghe inorganicnanomaterialswithintrinsicsingletoxygengenerationforphotodynamictherapy AT junlequ inorganicnanomaterialswithintrinsicsingletoxygengenerationforphotodynamictherapy AT jinglin inorganicnanomaterialswithintrinsicsingletoxygengenerationforphotodynamictherapy AT penghuang inorganicnanomaterialswithintrinsicsingletoxygengenerationforphotodynamictherapy AT xinghuaxia inorganicnanomaterialswithintrinsicsingletoxygengenerationforphotodynamictherapy |