Activity and Mechanism of Action of Antifungal Peptides from Microorganisms: A Review
Harmful fungi in nature not only cause diseases in plants, but also fungal infection and poisoning when people and animals eat food derived from crops contaminated with them. Unfortunately, such fungi are becoming increasingly more resistant to traditional synthetic antifungal drugs, which can make...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/11/3438 |
| _version_ | 1797531237985812480 |
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| author | Tianxi Li Lulu Li Fangyuan Du Lei Sun Jichao Shi Miao Long Zeliang Chen |
| author_facet | Tianxi Li Lulu Li Fangyuan Du Lei Sun Jichao Shi Miao Long Zeliang Chen |
| author_sort | Tianxi Li |
| collection | DOAJ |
| description | Harmful fungi in nature not only cause diseases in plants, but also fungal infection and poisoning when people and animals eat food derived from crops contaminated with them. Unfortunately, such fungi are becoming increasingly more resistant to traditional synthetic antifungal drugs, which can make prevention and control work increasingly more difficult to achieve. This means they are potentially very harmful to human health and lifestyle. Antifungal peptides are natural substances produced by organisms to defend themselves against harmful fungi. As a result, they have become an important research object to help deal with harmful fungi and overcome their drug resistance. Moreover, they are expected to be developed into new therapeutic drugs against drug-resistant fungi in clinical application. This review focuses on antifungal peptides that have been isolated from bacteria, fungi, and other microorganisms to date. Their antifungal activity and factors affecting it are outlined in terms of their antibacterial spectra and effects. The toxic effects of the antifungal peptides and their common solutions are mentioned. The mechanisms of action of the antifungal peptides are described according to their action pathways. The work provides a useful reference for further clinical research and the development of safe antifungal drugs that have high efficiencies and broad application spectra. |
| first_indexed | 2024-03-10T10:41:00Z |
| format | Article |
| id | doaj.art-6223c299af9d4c999ec17f492d630c1b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T10:41:00Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6223c299af9d4c999ec17f492d630c1b2023-11-21T22:57:24ZengMDPI AGMolecules1420-30492021-06-012611343810.3390/molecules26113438Activity and Mechanism of Action of Antifungal Peptides from Microorganisms: A ReviewTianxi Li0Lulu Li1Fangyuan Du2Lei Sun3Jichao Shi4Miao Long5Zeliang Chen6College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, ChinaCollege of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, ChinaCollege of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, ChinaCollege of Animal Husbandry and Veterinary Medicine, Jinzhou Medical University, Jinzhou 121001, ChinaLiaoning Agricultural Development Service Center, Shenyang 110032, ChinaCollege of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, ChinaCollege of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, ChinaHarmful fungi in nature not only cause diseases in plants, but also fungal infection and poisoning when people and animals eat food derived from crops contaminated with them. Unfortunately, such fungi are becoming increasingly more resistant to traditional synthetic antifungal drugs, which can make prevention and control work increasingly more difficult to achieve. This means they are potentially very harmful to human health and lifestyle. Antifungal peptides are natural substances produced by organisms to defend themselves against harmful fungi. As a result, they have become an important research object to help deal with harmful fungi and overcome their drug resistance. Moreover, they are expected to be developed into new therapeutic drugs against drug-resistant fungi in clinical application. This review focuses on antifungal peptides that have been isolated from bacteria, fungi, and other microorganisms to date. Their antifungal activity and factors affecting it are outlined in terms of their antibacterial spectra and effects. The toxic effects of the antifungal peptides and their common solutions are mentioned. The mechanisms of action of the antifungal peptides are described according to their action pathways. The work provides a useful reference for further clinical research and the development of safe antifungal drugs that have high efficiencies and broad application spectra.https://www.mdpi.com/1420-3049/26/11/3438antifungal peptideantibacterial activityantibacterial stabilitycytotoxicityantifungal mechanism |
| spellingShingle | Tianxi Li Lulu Li Fangyuan Du Lei Sun Jichao Shi Miao Long Zeliang Chen Activity and Mechanism of Action of Antifungal Peptides from Microorganisms: A Review Molecules antifungal peptide antibacterial activity antibacterial stability cytotoxicity antifungal mechanism |
| title | Activity and Mechanism of Action of Antifungal Peptides from Microorganisms: A Review |
| title_full | Activity and Mechanism of Action of Antifungal Peptides from Microorganisms: A Review |
| title_fullStr | Activity and Mechanism of Action of Antifungal Peptides from Microorganisms: A Review |
| title_full_unstemmed | Activity and Mechanism of Action of Antifungal Peptides from Microorganisms: A Review |
| title_short | Activity and Mechanism of Action of Antifungal Peptides from Microorganisms: A Review |
| title_sort | activity and mechanism of action of antifungal peptides from microorganisms a review |
| topic | antifungal peptide antibacterial activity antibacterial stability cytotoxicity antifungal mechanism |
| url | https://www.mdpi.com/1420-3049/26/11/3438 |
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