Scrophulariae Radix-Atractylodes sinensis pair and metformin inhibit inflammation by modulating gut microbiota of high-fat diet/streptozotocin-induced diabetes in rats
IntroductionType 2 mellitus (T2DM), a chronic metabolic disorder, causes severe impairment of patients’ quality of life and has attracted global attention. Many studies have suggested the importance of the gut microbiota in the occurrence of T2DM. The Scrophulariae Radix and Atractylodes sinensis (X...
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| Format: | Article |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.900021/full |
| _version_ | 1797986466763112448 |
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| author | Xiaoxia Guo Chong Wang Ranran Zhang Xuliang Hao Lei Lv Yan Ni Xiaohong Fan Weiliang Zhang Yunhong Jiao Wei Song Qi Dong Yuqi Qi Meiqing Song Xuemei Qin |
| author_facet | Xiaoxia Guo Chong Wang Ranran Zhang Xuliang Hao Lei Lv Yan Ni Xiaohong Fan Weiliang Zhang Yunhong Jiao Wei Song Qi Dong Yuqi Qi Meiqing Song Xuemei Qin |
| author_sort | Xiaoxia Guo |
| collection | DOAJ |
| description | IntroductionType 2 mellitus (T2DM), a chronic metabolic disorder, causes severe impairment of patients’ quality of life and has attracted global attention. Many studies have suggested the importance of the gut microbiota in the occurrence of T2DM. The Scrophulariae Radix and Atractylodes sinensis (XC) pair, recommended in traditional Chinese medicine (TCM), have been used for treating diabetes for many years. However, research on the role of the XC pair in modulating gut microbial communities is lacking, but it is important to elucidate the underlying mechanism.MethodsIn this study, we detected bacterial communities by high-throughput 16S rRNA gene sequencing.ResultsThe results showed that XC + MET reduced postprandial hyperglycemia and inflammatory response in diabetic rats more effectively than metformin (MET) alone. The XC + MET treatment reshaped the intestinal microbial composition of diabetic rats. XC can help MET regulate carbohydrate, amino acid, and lipid metabolism, particularly the insulin signaling pathway.DiscussionThis research would help elucidate potential mechanisms and the treatment methods. |
| first_indexed | 2024-04-11T07:33:56Z |
| format | Article |
| id | doaj.art-622454410efd4eb08b12df8edf138f02 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-11T07:33:56Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-622454410efd4eb08b12df8edf138f022022-12-22T04:36:48ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-11-011310.3389/fmicb.2022.900021900021Scrophulariae Radix-Atractylodes sinensis pair and metformin inhibit inflammation by modulating gut microbiota of high-fat diet/streptozotocin-induced diabetes in ratsXiaoxia Guo0Chong Wang1Ranran Zhang2Xuliang Hao3Lei Lv4Yan Ni5Xiaohong Fan6Weiliang Zhang7Yunhong Jiao8Wei Song9Qi Dong10Yuqi Qi11Meiqing Song12Xuemei Qin13Department of Metabolism, Shanxi Institute of Traditional Chinese Medicine, Taiyuan, Shanxi, ChinaDepartment of Metabolism, Shanxi Institute of Traditional Chinese Medicine, Taiyuan, Shanxi, ChinaDepartment of Metabolism, Shanxi Institute of Traditional Chinese Medicine, Taiyuan, Shanxi, ChinaTraditional Chinese Medicine Preparation Center, Affiliated Hospital of Shanxi University of Chinese Medicine, Taiyuan, Shanxi, ChinaDepartment of Metabolism, Shanxi Institute of Traditional Chinese Medicine, Taiyuan, Shanxi, ChinaDepartment of Metabolism, Shanxi Institute of Traditional Chinese Medicine, Taiyuan, Shanxi, ChinaDepartment of Metabolism, Shanxi Institute of Traditional Chinese Medicine, Taiyuan, Shanxi, ChinaDepartment of Metabolism, Shanxi Institute of Traditional Chinese Medicine, Taiyuan, Shanxi, ChinaDepartment of Metabolism, Shanxi Institute of Traditional Chinese Medicine, Taiyuan, Shanxi, ChinaDepartment of Metabolism, Shanxi Institute of Traditional Chinese Medicine, Taiyuan, Shanxi, ChinaDepartment of Metabolism, Shanxi Institute of Traditional Chinese Medicine, Taiyuan, Shanxi, ChinaDepartment of Metabolism, Shanxi Institute of Traditional Chinese Medicine, Taiyuan, Shanxi, ChinaClinical Pharmacological Research Laboratory, Shanxi Institute of Traditional Chinese Medicine, Taiyuan, Shanxi, ChinaModern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, Shanxi, ChinaIntroductionType 2 mellitus (T2DM), a chronic metabolic disorder, causes severe impairment of patients’ quality of life and has attracted global attention. Many studies have suggested the importance of the gut microbiota in the occurrence of T2DM. The Scrophulariae Radix and Atractylodes sinensis (XC) pair, recommended in traditional Chinese medicine (TCM), have been used for treating diabetes for many years. However, research on the role of the XC pair in modulating gut microbial communities is lacking, but it is important to elucidate the underlying mechanism.MethodsIn this study, we detected bacterial communities by high-throughput 16S rRNA gene sequencing.ResultsThe results showed that XC + MET reduced postprandial hyperglycemia and inflammatory response in diabetic rats more effectively than metformin (MET) alone. The XC + MET treatment reshaped the intestinal microbial composition of diabetic rats. XC can help MET regulate carbohydrate, amino acid, and lipid metabolism, particularly the insulin signaling pathway.DiscussionThis research would help elucidate potential mechanisms and the treatment methods.https://www.frontiersin.org/articles/10.3389/fmicb.2022.900021/fulltype 2 diabetes mellitusScrophulariae RadixAtractylodes sinensis pairmetformingut microbiota |
| spellingShingle | Xiaoxia Guo Chong Wang Ranran Zhang Xuliang Hao Lei Lv Yan Ni Xiaohong Fan Weiliang Zhang Yunhong Jiao Wei Song Qi Dong Yuqi Qi Meiqing Song Xuemei Qin Scrophulariae Radix-Atractylodes sinensis pair and metformin inhibit inflammation by modulating gut microbiota of high-fat diet/streptozotocin-induced diabetes in rats Frontiers in Microbiology type 2 diabetes mellitus Scrophulariae Radix Atractylodes sinensis pair metformin gut microbiota |
| title | Scrophulariae Radix-Atractylodes sinensis pair and metformin inhibit inflammation by modulating gut microbiota of high-fat diet/streptozotocin-induced diabetes in rats |
| title_full | Scrophulariae Radix-Atractylodes sinensis pair and metformin inhibit inflammation by modulating gut microbiota of high-fat diet/streptozotocin-induced diabetes in rats |
| title_fullStr | Scrophulariae Radix-Atractylodes sinensis pair and metformin inhibit inflammation by modulating gut microbiota of high-fat diet/streptozotocin-induced diabetes in rats |
| title_full_unstemmed | Scrophulariae Radix-Atractylodes sinensis pair and metformin inhibit inflammation by modulating gut microbiota of high-fat diet/streptozotocin-induced diabetes in rats |
| title_short | Scrophulariae Radix-Atractylodes sinensis pair and metformin inhibit inflammation by modulating gut microbiota of high-fat diet/streptozotocin-induced diabetes in rats |
| title_sort | scrophulariae radix atractylodes sinensis pair and metformin inhibit inflammation by modulating gut microbiota of high fat diet streptozotocin induced diabetes in rats |
| topic | type 2 diabetes mellitus Scrophulariae Radix Atractylodes sinensis pair metformin gut microbiota |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.900021/full |
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