Increasing trend of radiographic features of knee osteoarthritis in rheumatoid arthritis patients before total knee arthroplasty
Abstract To investigate the trend and factors related to the occurrence of osteoarthritis (OA)-like features on knee radiographs of rheumatoid arthritis (RA) patients undergoing total knee arthroplasty (TKA) in the recent decades. To classify antero-posterior knee radiographs into ‘RA’ and ‘OA-like...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-14440-2 |
| _version_ | 1818249832106557440 |
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| author | Ryutaro Takeda Takumi Matsumoto Yuji Maenohara Yasunori Omata Hiroshi Inui Yuichi Nagase Takuji Nishikawa Sakae Tanaka |
| author_facet | Ryutaro Takeda Takumi Matsumoto Yuji Maenohara Yasunori Omata Hiroshi Inui Yuichi Nagase Takuji Nishikawa Sakae Tanaka |
| author_sort | Ryutaro Takeda |
| collection | DOAJ |
| description | Abstract To investigate the trend and factors related to the occurrence of osteoarthritis (OA)-like features on knee radiographs of rheumatoid arthritis (RA) patients undergoing total knee arthroplasty (TKA) in the recent decades. To classify antero-posterior knee radiographs into ‘RA’ and ‘OA-like RA’ groups, a deep learning model was developed by training the network using knee radiographs of end-stage arthropathy in RA patients obtained during 2002–2005 and in primary OA patients obtained during 2007–2009. We used this model to categorize 796 knee radiographs, which were recorded in RA patients before TKA during 2006–2020, into ‘OA-like RA’ and ‘RA’ groups. The annual ratio of ‘OA-like RA’ was investigated. Moreover, univariate and multivariate analyses were performed to identify the factors associated with the classification as OA-like RA using clinical data from 240 patients. The percentage of ‘OA-like RA’ had significant increasing trend from 20.9% in 2006 to 67.7% in 2020. Higher body mass index, use of biologics, and lower level of C-reactive protein were identified as independent factors for ‘OA-like RA’. An increasing trend of knee radiographs with OA-like features was observed in RA patients in the recent decades, which might be attributed to recent advances in pharmacotherapy. |
| first_indexed | 2024-12-12T15:42:45Z |
| format | Article |
| id | doaj.art-622543a28d5f4e83bda48cd7cec6d79d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T15:42:45Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-622543a28d5f4e83bda48cd7cec6d79d2022-12-22T00:19:51ZengNature PortfolioScientific Reports2045-23222022-06-0112111010.1038/s41598-022-14440-2Increasing trend of radiographic features of knee osteoarthritis in rheumatoid arthritis patients before total knee arthroplastyRyutaro Takeda0Takumi Matsumoto1Yuji Maenohara2Yasunori Omata3Hiroshi Inui4Yuichi Nagase5Takuji Nishikawa6Sakae Tanaka7Department of Orthopaedic Surgery, Faculty of Medicine, The University of TokyoDepartment of Orthopaedic Surgery, Faculty of Medicine, The University of TokyoDepartment of Orthopaedic Surgery, Faculty of Medicine, The University of TokyoDepartment of Orthopaedic Surgery, Faculty of Medicine, The University of TokyoDepartment of Orthopaedic Surgery, Faculty of Medicine, The University of TokyoDepartment of Rheumatic Surgery, Tokyo Metropolitan Tama Medical CenterDepartment of Rheumatology, Tokyo Metropolitan Bokutoh HospitalDepartment of Orthopaedic Surgery, Faculty of Medicine, The University of TokyoAbstract To investigate the trend and factors related to the occurrence of osteoarthritis (OA)-like features on knee radiographs of rheumatoid arthritis (RA) patients undergoing total knee arthroplasty (TKA) in the recent decades. To classify antero-posterior knee radiographs into ‘RA’ and ‘OA-like RA’ groups, a deep learning model was developed by training the network using knee radiographs of end-stage arthropathy in RA patients obtained during 2002–2005 and in primary OA patients obtained during 2007–2009. We used this model to categorize 796 knee radiographs, which were recorded in RA patients before TKA during 2006–2020, into ‘OA-like RA’ and ‘RA’ groups. The annual ratio of ‘OA-like RA’ was investigated. Moreover, univariate and multivariate analyses were performed to identify the factors associated with the classification as OA-like RA using clinical data from 240 patients. The percentage of ‘OA-like RA’ had significant increasing trend from 20.9% in 2006 to 67.7% in 2020. Higher body mass index, use of biologics, and lower level of C-reactive protein were identified as independent factors for ‘OA-like RA’. An increasing trend of knee radiographs with OA-like features was observed in RA patients in the recent decades, which might be attributed to recent advances in pharmacotherapy.https://doi.org/10.1038/s41598-022-14440-2 |
| spellingShingle | Ryutaro Takeda Takumi Matsumoto Yuji Maenohara Yasunori Omata Hiroshi Inui Yuichi Nagase Takuji Nishikawa Sakae Tanaka Increasing trend of radiographic features of knee osteoarthritis in rheumatoid arthritis patients before total knee arthroplasty Scientific Reports |
| title | Increasing trend of radiographic features of knee osteoarthritis in rheumatoid arthritis patients before total knee arthroplasty |
| title_full | Increasing trend of radiographic features of knee osteoarthritis in rheumatoid arthritis patients before total knee arthroplasty |
| title_fullStr | Increasing trend of radiographic features of knee osteoarthritis in rheumatoid arthritis patients before total knee arthroplasty |
| title_full_unstemmed | Increasing trend of radiographic features of knee osteoarthritis in rheumatoid arthritis patients before total knee arthroplasty |
| title_short | Increasing trend of radiographic features of knee osteoarthritis in rheumatoid arthritis patients before total knee arthroplasty |
| title_sort | increasing trend of radiographic features of knee osteoarthritis in rheumatoid arthritis patients before total knee arthroplasty |
| url | https://doi.org/10.1038/s41598-022-14440-2 |
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